The Experts below are selected from a list of 8484 Experts worldwide ranked by ideXlab platform

Buddy D Ratner - One of the best experts on this subject based on the ideXlab platform.

  • Forty-nine years in Biomaterials Science: an interview with Buddy Ratner.
    Future science OA, 2017
    Co-Authors: Buddy D Ratner
    Abstract:

    Buddy Ratner talks to Francesca Lake, Managing Editor. After receiving his PhD in polymer chemistry from the Polytechnic Institute of Brooklyn (USA) in 1972, Ratner moved to the University of Washington (USA), where he has since become joint professor of bioengineering and chemical engineering and Michael L & Myrna Darland Endowed Chair in Technology Commercialization. Since 1996, he has led the UWEB Research Center for Biomaterials at the University of Washington, originally funded by the National Science Foundation. A pioneer of the Biomaterials field, Ratner's research interests include Biomaterials, tissue engineering, polymers, biocompatibility and surface analysis of organic materials. A leader in the field, he has received numerous awards, has launched several companies and holds over 20 patents.

  • Microscopy for Biomaterials Science
    Biomaterials Science, 2013
    Co-Authors: Kip D. Hauch, Buddy D Ratner
    Abstract:

    This chapter will familiarize the reader with the more common microscopy tools used in current Biomaterials research. The key concepts of magnification, resolution, and contrast are first introduced and then their meaning explored in the context of light microscopy. Digital imaging is very briefly addressed. Attention then moves to the electron microscopies, specifically SEM. Finally, new developments in optical microscopy are addressed that are shattering limitations of microscopy that have inhibited progress for hundreds of years. A brief guide to some useful resources is found at the end of the chapter.

  • Correlation, Materials Properties, Statistics and Biomaterials Science
    Biomaterials Science, 2013
    Co-Authors: Buddy D Ratner
    Abstract:

    What are the prospects for physical and chemical measurements for predicting the performance of new materials in complex medical applications? Can we find relationships between the composition and structure of a biomaterial and its biological interactions, particularly in complex systems like living organisms? The reality is that physical or chemical measurements which can reliably predict in vivo biocompatibility are at this time unavailable for most Biomaterials. It would be ideal to use a spectroscopic technique to measure the properties and predict how well the material will work in a particular application. Animal experiments are expensive, of questionable value for predicting performance in humans, and raise ethical issues. Human clinical trials are very expensive, and also raise ethical issues. Can we predict or prescreen in vivo or in vitro performance from measurements of surface and other physical and chemical properties? This chapter, addressing correlation, will examine this question, and offer suggestions for future exploration.

  • Biomaterials Science (Third Edition) - The Concept and Assessment of Biocompatibility
    Biomaterials Science, 2013
    Co-Authors: Buddy D Ratner, Frederick J. Schoen
    Abstract:

    Abstract This chapter clarifies some of the issues in biocompatibility, and also raises questions that will likely impact the field in the coming years. In contrast to empirical approaches and practical considerations focused solely about the safety of implanted devices (for example, toxicology, the state of the art today), modern cell and molecular biology ideas may give us a useful “theory of biocompatibility” with quantifiable parameters, testable hypotheses, and validated engineering rules.

  • Biomaterials Science an introduction to materials in medicine
    1996
    Co-Authors: Buddy D Ratner
    Abstract:

    B.D. Ratner, Biomaterials Science: An Interdisciplinary Endeavor. Materials Science and Engineering--Properties of Materials: J.E. Lemons, Introduction. F.W. Cooke, Bulk Properties of Materials. B.D. Ratner, Surface Properties of Materials. Classes of Materials Used in Medicine: A.S. Hoffman, Introduction. J.B. Brunski, Metals. S.A. Visser, R.W. Hergenrother, and S.L. Cooper, Polymers. N.A. Peppas, Hydrogels. J. Kohnand R. Langer, Bioresorbable and Bioerodible Materials. L.L. Hench, Ceramics, Glasses, and Glass Ceramics. I.V. Yannas, Natural Materials. H. Alexander, Composites. B.D. Ratner and A.S. Hoffman, Thin Films, Grafts, and Coatings. S.W. Shalaby, Fabrics. A.S. Hoffman, Biologically Functional Materials. Biology, Biochemistry, and Medicine--Some Background Concepts: B.D. Ratner, Introduction. T.A. Horbett, Proteins: Structure, Properties, and Adsorption to Surfaces. J.M. Schakenraad, Cells: Their Surfaces and Interactions with Materials. F.J. Schoen, Tissues. Host Reactions to Biomaterials and Their Evaluations: F.J. Schoen, Introduction. J.M. Anderson, Inflammation, Wound Healing, and the Foreign Body Response. R.J. Johnson, Immunology and the Complement System. K. Merritt, Systemic Toxicity and Hypersensitivity. S.R. Hanson and L.A. Harker, Blood Coagulation and Blood-Materials Interaction. F.J.Schoen, Tumorigenesis and Biomaterials. A.G. Gristina and P.T. Naylor, Implant-Associated Infection. Testing Biomaterials: B.D. Ratner, Introduction. S.J. Northup, In Vitro Assessment of Tissue Compatibility. M. Spector and P.A. Lalor, In Vivo Assessment of Tissue Compatibility. S. Hanson and B.D. Ratner, Testing of Blood-Material Interactions. B.H. Vale, J.E. Willson, and S.M. Niemi, Animal Models. Degradation of Materials in the Biological Environment: B.D. Ratner, Introduction. A.J. Coury, Chemical and Biochemical Degradation of Polymers. D.F. Williams and R.L. Williams, Degradative Effects of the Biological Environment on Metals and Ceramics. C.R. McMillin, Mechanical Breakdown in the Biological Environment. Y. Pathak, F.J. Schoen, and R.J. Levy, Pathologic Calcification of Biomaterials. Application of Materials in Medicine and Dentistry: J.E. Lemons, Introduction. D. Didisheim and J.T. Watson, Cardiovascular Applications. S.W. Kim, Nonthrombogenic Treatments and Strategies. J.E. Lemons, Dental Implants. D.C. Smith, Adhesives and Sealants. M.F. Refojo, Ophthalmologic Applications. J.L. Katz, Orthopedic Applications. J. Heller, Drug Delivery Systems. D. Goupil, Sutures. J.B. Kane, R.G. Tompkins, M.L. Yarmush, and J.F. Burke, Burn Dressings. L.S. Robblee and J.D. Sweeney, Bioelectrodes. P. Yager, Biomedical Sensors and Biosensors. Artificial Organs: F.J. Schoen, Introduction. K.D. Murray and D.B. Olsen, Implantable Pneumatic Artificial Hearts. P. Malchesky, Extracorporeal Artificial Organs. Practical Aspects of Biomaterials--Implants and Devices: F.J. Schoen, Introduction. J.B. Kowalski and R.F. Morrissey, Sterilization of Implants. L.M. Graham, D. Whittlesey, and B. Bevacqua, Cardiovascular Implantation. A.N. Cranin, M. Klein, and A. Sirakian, Dental Implantation. S.A. Obstbaum, Ophthalmic Implantation. A.E. Hoffman, Implant and Device Failure. B.D. Ratner, Correlations of Material Surface Properties with Biological Responses. J.M. Anderson, Implant Retrieval and Evaluation. New Products and Standards: J.E. Lemons, Introduction. S.A. Brown, Voluntary Consensus Standards. N.B. Mateo, Product Development and Regulation. B. Ratner, Perspectives and Possibilities in Biomaterials Science. Appendix: S. Slack, Properties of Biological Fluids. Subject Index.

Beatriu Escuder - One of the best experts on this subject based on the ideXlab platform.

  • towards supramolecular catalysis with small self assembled peptides
    Israel Journal of Chemistry, 2015
    Co-Authors: Nishant Singh, Juan F. Miravet, Marta Tenasolsona, Beatriu Escuder
    Abstract:

    Self-assembly of small peptides offers unique opportunities for the bottom-up construction of supramolecular catalysts that aim to emulate the efficiency and selectivity of natural enzymes. Small, information-rich, simple molecules based on amino acids can self-organise autonomously into complex systems with emergent catalytic properties. The power of noncovalent interactions can be used to construct supramolecular peptidic tertiary structures. Moreover, specific functional groups present in amino acid side-chains may present either a catalytic activity by themselves or be able to bind cofactors such as metal ions. In this scenario, although relevant progress has been achieved in recent years, promising applications in Biomaterials Science are foreseen. In this review, we discuss the state-of-the-art of this approach at the interface between supramolecular chemistry and peptide Science.

  • Towards Supramolecular Catalysis with Small Self‐assembled Peptides
    Israel Journal of Chemistry, 2015
    Co-Authors: Nishant Singh, Marta Tena-solsona, Juan F. Miravet, Beatriu Escuder
    Abstract:

    Self-assembly of small peptides offers unique opportunities for the bottom-up construction of supramolecular catalysts that aim to emulate the efficiency and selectivity of natural enzymes. Small, information-rich, simple molecules based on amino acids can self-organise autonomously into complex systems with emergent catalytic properties. The power of noncovalent interactions can be used to construct supramolecular peptidic tertiary structures. Moreover, specific functional groups present in amino acid side-chains may present either a catalytic activity by themselves or be able to bind cofactors such as metal ions. In this scenario, although relevant progress has been achieved in recent years, promising applications in Biomaterials Science are foreseen. In this review, we discuss the state-of-the-art of this approach at the interface between supramolecular chemistry and peptide Science.

Jan De Boer - One of the best experts on this subject based on the ideXlab platform.

  • Stepping into the omics era: opportunities and challenges for Biomaterials Science and engineering
    Acta biomaterialia, 2016
    Co-Authors: Nathalie Groen, Murat Guvendiren, Herschel Rabitz, William J. Welsh, Joachim Kohn, Jan De Boer
    Abstract:

    The research paradigm in Biomaterials Science and engineering is evolving from using low-throughput and iterative experimental designs towards high-throughput experimental designs for materials optimization and the evaluation of materials properties. Computational Science plays an important role in this transition. With the emergence of the omics approach in the Biomaterials field, referred to as materiomics, high-throughput approaches hold the promise of tackling the complexity of materials and understanding correlations between material properties and their effects on complex biological systems. The intrinsic complexity of biological systems is an important factor that is often oversimplified when characterizing biological responses to materials and establishing property-activity relationships. Indeed, in vitro tests designed to predict in vivo performance of a given biomaterial are largely lacking as we are not able to capture the biological complexity of whole tissues in an in vitro model. In this opinion paper, we explain how we reached our opinion that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field. In this opinion paper, we postulate that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field. Copyright © 2016. Published by Elsevier Ltd.

  • Stepping into the omics era: opportunities and challenges for Biomaterials Science and engineering
    Acta biomaterialia, 2016
    Co-Authors: Nathalie Groen, Murat Guvendiren, Herschel Rabitz, William J. Welsh, Joachim Kohn, Jan De Boer
    Abstract:

    Abstract The research paradigm in Biomaterials Science and engineering is evolving from using low-throughput and iterative experimental designs towards high-throughput experimental designs for materials optimization and the evaluation of materials properties. Computational Science plays an important role in this transition. With the emergence of the omics approach in the Biomaterials field, referred to as materiomics, high-throughput approaches hold the promise of tackling the complexity of materials and understanding correlations between material properties and their effects on complex biological systems. The intrinsic complexity of biological systems is an important factor that is often oversimplified when characterizing biological responses to materials and establishing property-activity relationships. Indeed, in vitro tests designed to predict in vivo performance of a given biomaterial are largely lacking as we are not able to capture the biological complexity of whole tissues in an in vitro model. In this opinion paper, we explain how we reached our opinion that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field. Statement of Significance In this opinion paper, we postulate that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field.

Joachim Kohn - One of the best experts on this subject based on the ideXlab platform.

  • Stepping into the omics era: opportunities and challenges for Biomaterials Science and engineering
    Acta biomaterialia, 2016
    Co-Authors: Nathalie Groen, Murat Guvendiren, Herschel Rabitz, William J. Welsh, Joachim Kohn, Jan De Boer
    Abstract:

    The research paradigm in Biomaterials Science and engineering is evolving from using low-throughput and iterative experimental designs towards high-throughput experimental designs for materials optimization and the evaluation of materials properties. Computational Science plays an important role in this transition. With the emergence of the omics approach in the Biomaterials field, referred to as materiomics, high-throughput approaches hold the promise of tackling the complexity of materials and understanding correlations between material properties and their effects on complex biological systems. The intrinsic complexity of biological systems is an important factor that is often oversimplified when characterizing biological responses to materials and establishing property-activity relationships. Indeed, in vitro tests designed to predict in vivo performance of a given biomaterial are largely lacking as we are not able to capture the biological complexity of whole tissues in an in vitro model. In this opinion paper, we explain how we reached our opinion that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field. In this opinion paper, we postulate that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field. Copyright © 2016. Published by Elsevier Ltd.

  • Stepping into the omics era: opportunities and challenges for Biomaterials Science and engineering
    Acta biomaterialia, 2016
    Co-Authors: Nathalie Groen, Murat Guvendiren, Herschel Rabitz, William J. Welsh, Joachim Kohn, Jan De Boer
    Abstract:

    Abstract The research paradigm in Biomaterials Science and engineering is evolving from using low-throughput and iterative experimental designs towards high-throughput experimental designs for materials optimization and the evaluation of materials properties. Computational Science plays an important role in this transition. With the emergence of the omics approach in the Biomaterials field, referred to as materiomics, high-throughput approaches hold the promise of tackling the complexity of materials and understanding correlations between material properties and their effects on complex biological systems. The intrinsic complexity of biological systems is an important factor that is often oversimplified when characterizing biological responses to materials and establishing property-activity relationships. Indeed, in vitro tests designed to predict in vivo performance of a given biomaterial are largely lacking as we are not able to capture the biological complexity of whole tissues in an in vitro model. In this opinion paper, we explain how we reached our opinion that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field. Statement of Significance In this opinion paper, we postulate that converging genomics and materiomics into a new field would enable a significant acceleration of the development of new and improved medical devices. The use of computational modeling to correlate high-throughput gene expression profiling with high throughput combinatorial material design strategies would add power to the analysis of biological effects induced by material properties. We believe that this extra layer of complexity on top of high-throughput material experimentation is necessary to tackle the biological complexity and further advance the Biomaterials field.

  • Can we regrow a human arm? An overview and summary.
    Journal of materials science. Materials in medicine, 2013
    Co-Authors: Joachim Kohn
    Abstract:

    The honorary status of ‘‘Fellow of Biomaterials Science and Engineering’’ (FBSE) was established in April 1992 after the constituent Biomaterials societies of the World Biomaterials Congress, now the International Union of Societies for Biomaterials Science and Engineering (IUSBSE), recognized the need for the public recognition of those members who have gained a status of excellent professional standing and high achievements in the fields of Biomaterials Science and engineering. Fellows are expected, through word and deed, to foster the field of Biomaterials and to support its professional development as a practical and intellectual endeavor. Since 1992, every 4 years, the national and regional Biomaterials societies of Australasia, Canada, China, Taiwan, Europe, India, Japan, Korea, Latin America, and the USA nominate their most prominent scientists for the honor of being inducted as Fellows into the International College of Fellows of Biomaterials Science and Engineering (ICF-BSE). Today, the ICF-BSE has 268 members. At the 8th World Biomaterials Congress in Amsterdam (June 2008), the ICF-BSE organized for the first time a ‘‘Special Fellows’ Session’’ as part of the scientific programming of the meeting. This first session was a traditional debate conducted by members of the ICF-BSE on the utility of animal experimentation as a predictive tool for the success or failure of a medical implant in humans. The debate pitched several speakers in favor of animal experimentation against an even number of speakers who argued for the opposing viewpoint. This lively debate was a welcome addition to the common presentation format and was well received by the audience. Four years later, at the 9th Biomaterials Congress in Chengdu, China (June 2012), the Special Fellows Session was devoted to the provocative question: ‘‘Can we regrow a human arm?’’ Considering that the ultimate goal of regenerative medicine is to restore both form and function of tissues and body parts that were lost due to trauma or disease, it was interesting to see how far we can possibly drive this concept. Historically, tissue engineers have been able to grow isolated human tissues in the laboratory. Skin, bone, muscle, and nerve are examples of isolated tissues that can be generated in the laboratory. Even more complex structures such as a functioning human bladder have been engineered from a Biomaterials-based scaffold and autologous cells. However, there is currently no example of the successful regeneration of complex organs (such as heart or liver), or the clinical use of complex body parts (such as a whole joint, part of a limb, or facial features such as a living nose or ear). The reason the regeneration of complex organs or body parts is so challenging is our inability to control and guide the many different interactions among multiple cell types that have to be coordinated in order to grow a functional multi-cell structure. Simply stated, if the different cells, growth factors, signaling molecules, genes, and extracellular matrix components are the musicians in an orchestra, we do understand the actions and capabilities of most of the players, but we certainly lack the conductor who coordinates all the actions of the musicians in the orchestra. J. Kohn (&) New Jersey Center for Biomaterials, Rutgers – The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA e-mail: kohn@rutgers.edu

  • Building a Roadmap for Biomaterials Science and Technology to Serve Military Needs
    2004
    Co-Authors: Joachim Kohn
    Abstract:

    Abstract : In order to develop a requirements document detailing the medical product needs of the military that could be enabled by Biomaterials technologies, we conducted a planning conference on February 2-4, 2004 in Iselin, New Jersey. About 80 people representing the military medical enterprise, biomedical companies and academic researchers engaged in a workshop structured around the key topics of wound care, drug delivery, tissue engineering/restoration and sensors and diagnostics. The National Research Council's National Materials Advisory Board facilitated the process, and subsequently applied the highest level of scholarly and technological expertise to producing the "roadmap report" that appears in the appendix of this document. This report will provide the guidance necessary for the programs of the new Center for Military Biomaterials Research, a program of the New Jersey Center for Biomaterials.

David Williams - One of the best experts on this subject based on the ideXlab platform.

  • Essential Biomaterials Science
    2014
    Co-Authors: David Williams
    Abstract:

    1. The clinical necessity of Biomaterials in the twenty-first century 2. Essential materials Science 3. Biocompatibility pathways 4. Implantable medical devices and artificial organs 5. Regenerative medicine and tissue engineering 6. Drug and gene delivery 7. Imaging and diagnostic systems 8. Contemporary and future Biomaterials 9. Infrastructure of the Biomaterials industry.

  • A reappraisal of Biomaterials Science.
    Medical device technology, 2009
    Co-Authors: David Williams
    Abstract:

    Biomaterials have evolved over the past decade in response to the need for more sophisticated technologies for therapeutic and diagnostic purposes. We consider here the ways in which Biomaterials are changing and the consequences of this for medical technology.

  • The interface between Biomaterials Science and biotechnology.
    Medical device technology, 2007
    Co-Authors: David Williams
    Abstract:

    Biotechnology has evolved over the years, moving on from crop protection to drug discovery. Similarly, Biomaterials Science has moved forward from implantable medical device technology to drug and gene delivery and tissue engineering. It was perhaps inevitable that they should eventually meet.

  • A complete Biomaterials text
    Materials Today, 2005
    Co-Authors: David Williams
    Abstract:

    The new, expanded edition of Biomaterials Science provides comprehensive coverage of this growing, multidisciplinary field for students of all backgrounds, says David F. Williams

  • The clinical necessity of Biomaterials in the twenty-first century
    Essential Biomaterials Science, 1
    Co-Authors: David Williams
    Abstract:

    In this opening chapter you will be introduced to the extent to which health care products contribute to the delivery of therapeutic and diagnostic procedures across a massive array of clinical problems and solutions. Included here are examples of long-term implantable devices, procedures of regenerative medicine, the diagnosis of disease and injury, and the specialized delivery of drugs and genes. You will then see how Biomaterials Science has evolved in order to optimize the performance of these products. The concepts of Biomaterials Science are introduced, along with a general discussion of the requirements of Biomaterials and their essential characteristics. Health care products in medical practice You are an observer in a busy doctor’s clinic on a Monday morning during a cold wet month of the winter. This is a large polyclinic, which includes not only primary care physicians but a plethora of specialists, who deal with the diagnosis and uncomplicated treatments for a variety of conditions, ranging from dental and ophthalmological conditions, to neonatal care, trauma, geriatric complaints and common infectious diseases. A few hundred meters away is a major teaching hospital, able to deal with virtually every acute and chronic condition that is likely to be seen in this mid-size industrial city, which encompasses people of all ages and genetic background.