The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jiande Chen - One of the best experts on this subject based on the ideXlab platform.
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abnormal gastric slow waves in patients with functional dyspepsia assessed by multichannel electrogastrography
American Journal of Physiology-gastrointestinal and Liver Physiology, 2001Co-Authors: Xuemei Lin, Jiande ChenAbstract:The aim of this study was to utilize multichannel electrogastrography to investigate whether patients with functional dyspepsia had impaired propagation or coordination of gastric slow waves in the fasting state compared with healthy controls. The study was performed in 10 patients with functional dyspepsia and 11 healthy subjects. Gastric myoelectrical activity was measured by using surface electrogastrography with a specially designed four-channel device. The study was performed for 30 min or more in the fasting state. Special computer programs were developed for the computation of the propagation and coupling of the gastric slow wave. It was found that, compared with the healthy controls, the patients showed a significantly lower percentage of slow wave propagation (58.0 ± 8.9 vs. 89.9 ± 2.6%, P < 0.002) and a significantly lower percentage of slow wave coupling (46.9 ± 4.4 vs. 61.5 ± 6.9%, P < 0.04). In addition, the patients showed inconsistencies in the frequency and regularity of the gastric slow wave among the four-channel Electrogastrograms (EGGs). It was concluded that patients with functional dyspepsia have impaired slow wave propagation and coupling. Multichannel EGG has more information than single-channel EGG for the detection of gastric myoelectrical abnormalities.
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role of sham feeding in postprandial changes of gastric myoelectrical activity
Digestive Diseases and Sciences, 1996Co-Authors: Jiande Chen, Jie Pan, William C OrrAbstract:The aim of this study was to evaluate the role of sham feeding in postprandial changes of gastric myoelectrical activity. Eighteen asymptomatic healthy volunteers (10 men, 8 women; mean age: 31), with no history of gastrointestinal disease were studied. Gastric myoelectrical activity was recorded for 30 min at baseline, 30 min after sham feeding, and 1 hr after eating, using surface electrogastrography. The Electrogastrogram (EGG) was analyzed by spectral analysis. It was found that the changes of postprandial EGG parameters were significantly correlated with those after sham feeding (EGG dominant power:r=0.6,P<0.01; dominant frequency:r=0.8,P<0.001; percentage of regular slow waves:r=0.7,P<0.003). We concluded that intrinsic gastric electrical activity can be altered by sham feeding and the cephalic phase of digestion plays an important role in the postprandial response of gastric myoelectrical activity.
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abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis
Digestive Diseases and Sciences, 1996Co-Authors: Jiande Chen, Jie Pan, Zhiyue Lin, Richard W MccallumAbstract:Gastric myoelectrical activity modulates gastric motor activity. Abnormalities in gastric myoelectrical activity may be associated with gastric motility disorders. The aim of this study was to investigate the correlation of gastric myoelectrical activity with gastric emptying in symptomatic patients with and without gastroparesis. Ninety-seven patients with symptoms suggestive of gastroparesis participated in the study. Gastric myoelectrical activity was recorded using surface electrogastrography. The Electrogastrogram (EGG) was recorded for 30 min in the fasting state and for 120 min after a solid test meal. Gastric emptying of the solid meal was simultaneously monitored for 120 min. Patients with delayed gastric emptying showed a significantly lower percentage of normal gastric slow waves (P<0.03) and a significantly reduced increase of the dominant power in the postprandial EGG (P<0.02). Postprandial EGG parameters were found to be able to predict delayed emptying of the stomach. Postprandial gastric dysrhythmia predicts delayed gastric emptying with an accuracy of 78%, while the abnormality in postprandial EGG power predicts delayed gastric emptying with an accuracy of 75%. All patients with abnormalities in both the rhythmicity and the power had delayed gastric emptying. Patients with delayed gastric emptying have a lower percentage of normal gastric slow waves in the EGG and a lower postprandial increase in the dominant power. Abnormalities in the postprandial EGG seem to be able to predict delayed emptying of the stomach. However, a normal EGG does not seem to guarantee normal emptying of the stomach.
Jiande D Z Chen - One of the best experts on this subject based on the ideXlab platform.
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ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects
Journal of Gastroenterology and Hepatology, 2016Co-Authors: Zhihui Huang, Jieyun Yin, Nina Zhang, Ning Dai, Jiande D Z ChenAbstract:BACKGROUND Impaired gastric accommodation is recognized as one of major pathophysiologies in functional dyspepsia and gastroparesis. Electroacupuncture has been shown to improve gastric accommodation in laboratory settings. It is, however, unknown whether it exerts similar ameliorating effect in humans and whether needleless transcutaneous electroacupuncture (TEA) is also effective in improving gastric accommodation. AIM The aim was to investigate the effects of TEA on gastric accommodation, gastric slow waves, and dyspeptic related symptoms. METHODS Thirteen healthy volunteers were studied in four randomized sessions: control, cold nutrient liquid, cold nutrient liquid + sham-TEA, and cold nutrient liquid + TEA. The subjects were requested to drink Ensure until reaching maximum satiety. The Electrogastrogram (EGG) and electrocardiogram (ECG) were recorded to assess the gastric and autonomic functions respectively. RESULTS 1) Gastric accommodation was reduced with the cold drink in comparison with the warm drink (P = 0.023). TEA improved the impaired gastric accommodation from 539.2 ± 133.8 ml to 731.0 ± 185.7 ml (P = 0.005). 2) The percentage of normal gastric slow waves in six subjects was significantly decreased in the cold session (P = 0.002) and improved in the TEA session (P = 0.009 vs sham; P 0.05). CONCLUSIONS TEA improves impaired gastric accommodation and slow waves induced by cold drink and the effect does not seem to be mediated via the vagal mechanisms.
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correlations among Electrogastrogram gastric dysmotility and duodenal dysmotility in patients with functional dyspepsia
Journal of Clinical Gastroenterology, 2009Co-Authors: Pankaj J. Pasricha, Jiande D Z ChenAbstract:Aim: The aim of this study was to assess gastric slow waves, antral and duodenal motility simultaneously, and determine the correlation among all these measures in patients with functional dyspepsia. Methods: Thirty-one patients with functional dyspepsia were assessed for severity of upper gastrointestinal symptoms with the electrogastrography (EGG) and antroduodenal manometry. The EGG and manometry were recorded for 3 to 4 hours in the fasting state and for 2 hours after a solid meal. Computerized spectral analysis methods were used to compute various EGG parameters. Results: The EGG was abnormal in 71.0% of patients. The abnormalities included normal slow waves lower than 70% in the fasting state (51.6% of patients) and in the fed state (48.4% of patients), a decrease in dominant power in 28.9% of patients. Antral motility was abnormal in 80.6% of patients and duodenal motility was abnormal in 74.2% of patients. For the EGG and antral motility, 19 of 31 patients had both abnormal EGG and abnormal antral motility; 2 of 31 patients had both normal EGG and normal antral motility. For the EGG and duodenal motility, these values were 16/31 and 2/31, respectively. By both EGG and antroduodenal manometry, abnormal gastric motor function was found in 93.5% of patients. However, quantitative one-to-one correlation between any of the EGG parameters and the antroduodenal dysmotility was not noted. The patients showed high symptom scores particularly to upper abdominal pain, nausea, and belch. No one-to-one correlation was noted between the symptom scores and any of the EGG or motility parameters. Conclusions: More than two-thirds of patients with functional dyspepsia have abnormalities in the EGG and antral/duodenal motility. The sensitivity of these 2 different methods is essentially the same. EGG and antroduodenal manometry can complement each other in demonstrating gastric motor dysfunction in patients with functional dyspepsia.
Richard W Mccallum - One of the best experts on this subject based on the ideXlab platform.
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an evaluation of adult electrogastrography criteria in healthy children
Digestive Diseases and Sciences, 2006Co-Authors: Craig A Friesen, Zhiyue Lin, Jennifer Verril Schurman, Linda Andre, Richard W MccallumAbstract:The current study examined whether Electrogastrogram (EGG) recordings obtained from healthy children would be considered normal by standards established for adults and whether EGG patterns differ between children/adolescents and adults. Twenty-eight healthy children (54% females; ages 8–17 years; mean = 12.4 years) were evaluated and compared to 15 healthy adults evaluated previously. EGGs were recorded for 30 min in the fasting state and for 1 hr following a standard meal. For both pediatric and adult participants, there was a significant increase in both the dominant frequency and the dominant power from the pre- to the postprandial period (P < 0.001 for each). Using adult standards, the percentage normal slow waves was ≥70% of the recording time in 96% of children in the fasting state and in 100% in the postprandial period. A postprandial power increase was seen in 89% of the children. In conclusion, our data indicate that American Motility Society (AMS) consensus adult criteria for a normal EGG are appropriate to apply to children and adolescents when utilizing methodology and meal challenge similar to those used to establish the adult norms.
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absence of the interstitial cells of cajal in patients with gastroparesis and correlation with clinical findings
Journal of Gastrointestinal Surgery, 2005Co-Authors: Jameson Forster, Zhiyue Lin, Ivan Damjanov, Irene Sarosiek, Paul Wetzel, Richard W MccallumAbstract:The interstitial cells of Cajal (ICCs) are fundamental in the generation of gastric slow waves. The role of these cells in gastroparesis has not been established. We studied 14 gastroparetic patients (9 diabetic, 4 idiopathic, and 1 postsurgical) for whom standard medical therapy had failed and who had been treated with a gastric electrical stimulator for at least 3 months. All patients had a full-thickness antral gastric wall biopsy at the time of surgery. The biopsy samples were stained with c-kit and scored for the presence of ICCs. Baseline Electrogastrogram recordings were obtained for 30 minutes in the fasting state and for 2 hours after a test meal. The patients assessed their total symptom score at baseline and at 3 months. Five patients had almost no ICCs and were compared with nine patients with 20% to normal cell numbers. Both groups did respond symptomatically to gastric electrical stimulation. However, patients with depleted ICCs had significantly more tachygastria and had significantly greater total symptom scores at baseline and after 3 months of gastric electrical stimulation. ICCs are absent in some patients (up to a third) with diabetic or idiopathic gastroparesis, and the absence of these cells is associated with abnormalities of gastric slow waves, worse symptoms, and less improvement with gastric electrical stimulation.
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artifact reduction in Electrogastrogram based on empirical mode decomposition method
Medical & Biological Engineering & Computing, 2000Co-Authors: Hualou Liang, Zhiyue Lin, Richard W MccallumAbstract:Severe contamination of the gastric signal in Electrogastrogram (EGG) analysus by respiratory, motion, cardiac artifacts, and possible myoelectrical activity from other organs, poses a major challenge to EGG interpretation and analysis. A generally applicable method for removing a variety of artifacts from EGG recordings is proposed based on the empirical mode decomposition (EMD) method. This decomposition technique is adaptive, and appears to be uniquely suitable for nonlinear, non-stationary data analysis. The results show that this method, combined with instantaneous frequency analysis, effectively separate, identify and remove contamination from a wide variety of artifactual sources in EGG recordings.
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abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis
Digestive Diseases and Sciences, 1996Co-Authors: Jiande Chen, Jie Pan, Zhiyue Lin, Richard W MccallumAbstract:Gastric myoelectrical activity modulates gastric motor activity. Abnormalities in gastric myoelectrical activity may be associated with gastric motility disorders. The aim of this study was to investigate the correlation of gastric myoelectrical activity with gastric emptying in symptomatic patients with and without gastroparesis. Ninety-seven patients with symptoms suggestive of gastroparesis participated in the study. Gastric myoelectrical activity was recorded using surface electrogastrography. The Electrogastrogram (EGG) was recorded for 30 min in the fasting state and for 120 min after a solid test meal. Gastric emptying of the solid meal was simultaneously monitored for 120 min. Patients with delayed gastric emptying showed a significantly lower percentage of normal gastric slow waves (P<0.03) and a significantly reduced increase of the dominant power in the postprandial EGG (P<0.02). Postprandial EGG parameters were found to be able to predict delayed emptying of the stomach. Postprandial gastric dysrhythmia predicts delayed gastric emptying with an accuracy of 78%, while the abnormality in postprandial EGG power predicts delayed gastric emptying with an accuracy of 75%. All patients with abnormalities in both the rhythmicity and the power had delayed gastric emptying. Patients with delayed gastric emptying have a lower percentage of normal gastric slow waves in the EGG and a lower postprandial increase in the dominant power. Abnormalities in the postprandial EGG seem to be able to predict delayed emptying of the stomach. However, a normal EGG does not seem to guarantee normal emptying of the stomach.
Zhiyue Lin - One of the best experts on this subject based on the ideXlab platform.
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an evaluation of adult electrogastrography criteria in healthy children
Digestive Diseases and Sciences, 2006Co-Authors: Craig A Friesen, Zhiyue Lin, Jennifer Verril Schurman, Linda Andre, Richard W MccallumAbstract:The current study examined whether Electrogastrogram (EGG) recordings obtained from healthy children would be considered normal by standards established for adults and whether EGG patterns differ between children/adolescents and adults. Twenty-eight healthy children (54% females; ages 8–17 years; mean = 12.4 years) were evaluated and compared to 15 healthy adults evaluated previously. EGGs were recorded for 30 min in the fasting state and for 1 hr following a standard meal. For both pediatric and adult participants, there was a significant increase in both the dominant frequency and the dominant power from the pre- to the postprandial period (P < 0.001 for each). Using adult standards, the percentage normal slow waves was ≥70% of the recording time in 96% of children in the fasting state and in 100% in the postprandial period. A postprandial power increase was seen in 89% of the children. In conclusion, our data indicate that American Motility Society (AMS) consensus adult criteria for a normal EGG are appropriate to apply to children and adolescents when utilizing methodology and meal challenge similar to those used to establish the adult norms.
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electrogastrography in pediatric functional dyspepsia relationship to gastric emptying and symptom severity
Journal of Pediatric Gastroenterology and Nutrition, 2006Co-Authors: Craig A Friesen, Zhiyue Lin, Jennifer Verril Schurman, Linda Andre, Nanci Burchell, Jose T. Cocjin, Paul E Hyman, Elly Welchert, Shelia Pulliam, Anne MooreAbstract:ABSTRACTObjectives:The aims of this study were to determine the electrogastrographic patterns in children with functional dyspepsia and to investigate the correlations among Electrogastrogram (EGG), gastric emptying (GE), and pain severity.Methods:We studied 30 children (19 F; mean age 11.4 years) w
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absence of the interstitial cells of cajal in patients with gastroparesis and correlation with clinical findings
Journal of Gastrointestinal Surgery, 2005Co-Authors: Jameson Forster, Zhiyue Lin, Ivan Damjanov, Irene Sarosiek, Paul Wetzel, Richard W MccallumAbstract:The interstitial cells of Cajal (ICCs) are fundamental in the generation of gastric slow waves. The role of these cells in gastroparesis has not been established. We studied 14 gastroparetic patients (9 diabetic, 4 idiopathic, and 1 postsurgical) for whom standard medical therapy had failed and who had been treated with a gastric electrical stimulator for at least 3 months. All patients had a full-thickness antral gastric wall biopsy at the time of surgery. The biopsy samples were stained with c-kit and scored for the presence of ICCs. Baseline Electrogastrogram recordings were obtained for 30 minutes in the fasting state and for 2 hours after a test meal. The patients assessed their total symptom score at baseline and at 3 months. Five patients had almost no ICCs and were compared with nine patients with 20% to normal cell numbers. Both groups did respond symptomatically to gastric electrical stimulation. However, patients with depleted ICCs had significantly more tachygastria and had significantly greater total symptom scores at baseline and after 3 months of gastric electrical stimulation. ICCs are absent in some patients (up to a third) with diabetic or idiopathic gastroparesis, and the absence of these cells is associated with abnormalities of gastric slow waves, worse symptoms, and less improvement with gastric electrical stimulation.
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artifact reduction in Electrogastrogram based on empirical mode decomposition method
Medical & Biological Engineering & Computing, 2000Co-Authors: Hualou Liang, Zhiyue Lin, Richard W MccallumAbstract:Severe contamination of the gastric signal in Electrogastrogram (EGG) analysus by respiratory, motion, cardiac artifacts, and possible myoelectrical activity from other organs, poses a major challenge to EGG interpretation and analysis. A generally applicable method for removing a variety of artifacts from EGG recordings is proposed based on the empirical mode decomposition (EMD) method. This decomposition technique is adaptive, and appears to be uniquely suitable for nonlinear, non-stationary data analysis. The results show that this method, combined with instantaneous frequency analysis, effectively separate, identify and remove contamination from a wide variety of artifactual sources in EGG recordings.
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abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis
Digestive Diseases and Sciences, 1996Co-Authors: Jiande Chen, Jie Pan, Zhiyue Lin, Richard W MccallumAbstract:Gastric myoelectrical activity modulates gastric motor activity. Abnormalities in gastric myoelectrical activity may be associated with gastric motility disorders. The aim of this study was to investigate the correlation of gastric myoelectrical activity with gastric emptying in symptomatic patients with and without gastroparesis. Ninety-seven patients with symptoms suggestive of gastroparesis participated in the study. Gastric myoelectrical activity was recorded using surface electrogastrography. The Electrogastrogram (EGG) was recorded for 30 min in the fasting state and for 120 min after a solid test meal. Gastric emptying of the solid meal was simultaneously monitored for 120 min. Patients with delayed gastric emptying showed a significantly lower percentage of normal gastric slow waves (P<0.03) and a significantly reduced increase of the dominant power in the postprandial EGG (P<0.02). Postprandial EGG parameters were found to be able to predict delayed emptying of the stomach. Postprandial gastric dysrhythmia predicts delayed gastric emptying with an accuracy of 78%, while the abnormality in postprandial EGG power predicts delayed gastric emptying with an accuracy of 75%. All patients with abnormalities in both the rhythmicity and the power had delayed gastric emptying. Patients with delayed gastric emptying have a lower percentage of normal gastric slow waves in the EGG and a lower postprandial increase in the dominant power. Abnormalities in the postprandial EGG seem to be able to predict delayed emptying of the stomach. However, a normal EGG does not seem to guarantee normal emptying of the stomach.
Jieyun Yin - One of the best experts on this subject based on the ideXlab platform.
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Electrogastrography: methodology, validation and applications
2016Co-Authors: Jieyun Yin, E D Z ChenAbstract:Electrogastrography (EGG) is a non-invasive method for the measurement of gastric myoelectrical activity. It was first dis-covered in 1921 and popularized in 1990s. EGG is attractive because it is non-invasive. However, due to its non-invasive na-ture, there have also been controversies regarding validity and applications of EGG. The aim of this review is to discuss the methodologies, validation and applications of EGG. Pros and cons of EGG will also be discussed in detail. First, the gastric slow wave and its correlation with gastric motility are presented. The association between gastric dysrhythmia and impaired gastric motility is reviewed. Secondly the method for recording the Electrogastrogram is presented in detail and pitfalls in the recording and analysis of EGG are discussed. Thirdly, findings reported in the literature demonstrating the accuracy of EGG in recording gastric slow waves and gastric dysrhythmia are reviewed and discussed. The correlation of the Electrogastrogram with gastric contraction is carefully discussed. Finally, applications of EGG in a few major areas are reviewed. (J Neurogastroenterol Motil 2013;19:5-17
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ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects
Journal of Gastroenterology and Hepatology, 2016Co-Authors: Zhihui Huang, Jieyun Yin, Nina Zhang, Ning Dai, Jiande D Z ChenAbstract:BACKGROUND Impaired gastric accommodation is recognized as one of major pathophysiologies in functional dyspepsia and gastroparesis. Electroacupuncture has been shown to improve gastric accommodation in laboratory settings. It is, however, unknown whether it exerts similar ameliorating effect in humans and whether needleless transcutaneous electroacupuncture (TEA) is also effective in improving gastric accommodation. AIM The aim was to investigate the effects of TEA on gastric accommodation, gastric slow waves, and dyspeptic related symptoms. METHODS Thirteen healthy volunteers were studied in four randomized sessions: control, cold nutrient liquid, cold nutrient liquid + sham-TEA, and cold nutrient liquid + TEA. The subjects were requested to drink Ensure until reaching maximum satiety. The Electrogastrogram (EGG) and electrocardiogram (ECG) were recorded to assess the gastric and autonomic functions respectively. RESULTS 1) Gastric accommodation was reduced with the cold drink in comparison with the warm drink (P = 0.023). TEA improved the impaired gastric accommodation from 539.2 ± 133.8 ml to 731.0 ± 185.7 ml (P = 0.005). 2) The percentage of normal gastric slow waves in six subjects was significantly decreased in the cold session (P = 0.002) and improved in the TEA session (P = 0.009 vs sham; P 0.05). CONCLUSIONS TEA improves impaired gastric accommodation and slow waves induced by cold drink and the effect does not seem to be mediated via the vagal mechanisms.
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Ameliorating Effect of Transcutaneous Electroacupuncture on Impaired Gastric Accommodation in Patients with Postprandial Distress Syndrome-Predominant Functional Dyspepsia: A Pilot Study
Hindawi Limited, 2015Co-Authors: Yan Tan, Zhihui Huang, Nina Zhang, Jieyun YinAbstract:Patients with functional dyspepsia (FD) have both reduced gastric accommodation and impaired gastric motility that are difficult to treat. The aim of this study was to investigate the therapeutic potential of transcutaneous electroacupuncture (TEA) for both of these disorders in FD patients. Acute experiments were performed in FD patients to study the effect of TEA and sham-TEA on gastric accommodation assessed by a nutrient drink test and gastric motility assessed by the measurement of the Electrogastrogram (EGG). TEA or sham-TEA was performed via cutaneous electrodes at acupoints ST36 and PC6 or sham-points nonacupoints. It was found that (1) gastric accommodation (maximum tolerable volume) was reduced in FD patients compared with the controls P
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Research Article Ameliorating Effect of Transcutaneous Electroacupuncture on Impaired Gastric Accommodation in Patients with Postprandial Distress Syndrome-Predominant Functional Dyspepsia: A Pilot Study
2014Co-Authors: Yan Tan, Zhihui Huang, Nina Zhang, Jieyun YinAbstract:Copyright © 2015 Feng Xu et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Patients with functional dyspepsia (FD) have both reduced gastric accommodation and impaired gastric motility that are difficult to treat. The aim of this study was to investigate the therapeutic potential of transcutaneous electroacupuncture (TEA) for both of these disorders in FD patients. Acute experiments were performed in FD patients to study the effect of TEA and sham-TEA on gastric accommodation assessed by a nutrient drink test and gastric motility assessed by the measurement of the Electrogastrogram (EGG). TEA or sham-TEA was performed via cutaneous electrodes at acupoints ST36 and PC6 or sham-points nonacupoints. It was found that (1) gastric accommodation (maximum tolerable volume) was reduced in FD patients compared with the controls
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electrogastrography methodology validation and applications
Journal of Neurogastroenterology and Motility, 2013Co-Authors: Jieyun Yin, J D Z ChenAbstract:Electrogastrography (EGG) is a non-invasive method for the measurement of gastric myoelectrical activity. It was first discovered in 1921 and popularized in 1990s. EGG is attractive because it is non-invasive. However, due to its non-invasive nature, there have also been controversies regarding validity and applications of EGG. The aim of this review is to discuss the methodologies, validation and applications of EGG. Pros and cons of EGG will also be discussed in detail. First, the gastric slow wave and its correlation with gastric motility are presented. The association between gastric dysrhythmia and impaired gastric motility is reviewed. Secondly the method for recording the Electrogastrogram is presented in detail and pitfalls in the recording and analysis of EGG are discussed. Thirdly, findings reported in the literature demonstrating the accuracy of EGG in recording gastric slow waves and gastric dysrhythmia are reviewed and discussed. The correlation of the Electrogastrogram with gastric contraction is carefully discussed. Finally, applications of EGG in a few major areas are reviewed.