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Arja T Erkkila - One of the best experts on this subject based on the ideXlab platform.
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intake of camelina sativa oil and Fatty Fish alter the plasma lipid mediator profile in subjects with impaired glucose metabolism a randomized controlled trial
2020Co-Authors: Topi Meuronen, Arja T Erkkila, Maria Lankinen, Vanessa D De Mello, David E. Laaksonen, Alexander Fauland, Bunichi Shimizu, Craig E Wheelock, Ursula SchwabAbstract:n-3 and n-6 polyunsaturated Fatty acids (PUFAs) and their lipid mediator metabolites are associated with inflammation. We investigated the effect of dietary intake of plant- and animal-derived n-3 PUFAs and Fish protein on the circulatory concentrations of lipid mediators. Seventy-nine subjects with impaired fasting glucose who completed the controlled dietary intervention after randomization to the Fatty Fish (FF, n=20), lean Fish (LF, n=21), Camelina sativa oil (CSO, n=18) or control group (n=20) for 12 weeks were studied. Lipid mediator profiling from fasting plasma samples before and after the intervention was performed by liquid chromatography-mass spectrometry (LC-MS/MS). The FF diet increased concentrations of 18-hydroxyeicosapentaenoic acid (18-HEPE) and 4- and 17-hydroxydocosahexaenoic acid (4-, 17-HDoHE) derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively. Concentrations of lipid mediators derived from α-linolenic acid (ALA) increased and arachidonic acid (AA) derived 5-iso prostaglandin F2α-VI decreased in the CSO group. There were no significant changes in lipid mediators in the LF group. The dietary intake of both plant and animal-based n-3 PUFAs increased circulatory concentrations of lipid mediators with potential anti-inflammatory properties.
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camelina sativa oil Fatty Fish and lean Fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism
2019Co-Authors: Arja T Erkkila, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Vanessa D De Mello, Ursula SchwabAbstract:Dietary Fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if Fatty Fish, lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, Fatty Fish, lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid Fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value <0.001). In the Fatty Fish group, proportions of eicosapentaenoic and docosahexaenoic acids increased (overall p-value <0.001 for both). Prostaglandin F2α was higher in the CSO group than in the control group (p < 0.05), however, there were no other significant changes in urinary excretion of other prostanoids among the study groups. At baseline, arachidonic acid in plasma phospholipids was positively (r = 0.247, p < 0.05) and ALA negatively (r = -0.326, p < 0.05) associated with urinary total isoprostanes. In conclusion, CSO, Fatty Fish, and lean Fish consumption do not cause major changes in oxidative stress markers in subjects with impaired glucose tolerance.
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The effect of different sources of Fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial
2019Co-Authors: Vanessa D De Mello, Maria Lankinen, Sudhir Kurl, David E. Laaksonen, Ingrid Dahlman, Leena Pitkänen, Ursula S. Schwab, Arja T ErkkilaAbstract:Background/Objectives Molecular mechanisms linking Fish and vegetable oil intakes to their healthy metabolic effects may involve attenuation of inflammation. Our primary aim was to examine in a randomized controlled setting whether diets enriched in Fatty Fish (FF), lean Fish (LF) or ALA-rich camelina sativa oil (CSO) differ in their effects on the mRNA expression response of selected inflammation-related genes in peripheral blood mononuclear cells (PBMCs) and subcutaneous adipose tissue (SAT) in subjects with impaired fasting glucose. Subjects/Methods Samples from 72 participants randomized to one of the following 12-week intervention groups, FF ( n = 19), LF ( n = 19), CSO ( n = 17) or a control group ( n = 17), were available for the PBMC study. For SAT, 39 samples ( n = 8, n = 10, n = 9, n = 12, respectively) were available. The mRNA expression was measured at baseline and 12 weeks by TaqMan® Low Density Array. Results In PBMCs, LF decreased ICAM1 mRNA expression ( P
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Camelina sativa oil, Fatty Fish or lean Fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism
2019Co-Authors: Arja T Erkkila, Oger C., Vanessa D De Mello, Jc Lee, Lankinen M, Manninen S, Hh Leung, Us SchwabAbstract:Dietary Fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if Fatty Fish, lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43–72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, Fatty Fish, lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha‐linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α, 5‐F2t‐isoprostanes and 15‐F2t‐isoprostane metabolites, isofuran, 8‐F3t‐isoprostanes, and 4‐(RS)‐4‐F4t‐neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2) collected over 12‐h were measured using liquid chromatography tandem‐mass spectrometry. Plasma phospholipid Fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p‐value
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Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism-A Randomized Controlled Trial.
2018Co-Authors: Ursula Schwab, Maria Lankinen, Vanessa D De Mello, Suvi M. Manninen, Sudhir Kurl, Kari Pulkki, David E. Laaksonen, Arja T ErkkilaAbstract:SCOPE The aim of the study is to examine whether lean Fish (LF), Fatty Fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four Fish meals/week), LF (four Fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of Fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
Lars Hagmar - One of the best experts on this subject based on the ideXlab platform.
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female fertility in relation to the consumption of Fish contaminated with persistent organochlorine compounds
2002Co-Authors: Anna Axmon, Ulf Stromberg, Lars Rylander, Lars HagmarAbstract:OBJECTIVES: The purpose of the study was to assess the effect of exposure to presistent organochlorine compounds through the consumption of Fatty Fish from the Baltic Sea on human fertility. METHODS: Information on time to pregnancy, miscarriages, and subfertility was collected retrospectively by self-administered questionnaires in two cohorts of Fishermen's sisters from the Swedish east coast, by the Baltic Sea, and the west coast, where Fish are less contaminated. Along with cohort affiliation, Fish consumption and growing up in a Fishing village or Fisherman's family were used as measures of exposure within the eastcoast cohort (ie, the exposed cohort). RESULTS: There was no support for a negative effect of the consumption of Fatty Baltic Sea Fish on time to pregnancy, miscarriages, or subfertility. On the contrary, some evidence pointed towards a protective effect of Fatty Fish consumption within both cohorts. CONCLUSIONS: No evidence of reduced fertility was found for women who could be assumed to have a high lifetime consumption of Fatty Fish contaminated by persistent organochlorine compounds. A possible explanation for this finding is that a positive effect of some of the constituents in Fatty Fish could be strong enough to disguise the hazardous effects of exposure to persistent organochlorine compounds. (Less)
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time to pregnancy and infertility among women with a high intake of Fish contaminated with persistent organochlorine compounds
2000Co-Authors: Anna Axmon, Ulf Stromberg, Lars Rylander, Lars HagmarAbstract:OBJECTIVES: The purpose of this study was to assess the effect of persistent organochlorine compounds through the dietary intake of Fatty Fish from the Baltic Sea on human fertility. METHODS: Information on time to pregnancy, subfertility, and infertility was collected retrospectively by self-administered questionnaires in 2 cohorts of Fishermen's wives from the Swedish east (by the Baltic Sea) and west coasts. In addition to cohort affiliation, current Fish consumption and growing up in a Fishing village were used as proxies for exposure within the eastcoast cohort. RESULTS: A decreased success (ie, pregnancy) rate and a tendency towards increased subfertility was found for heavy smokers (> or =10 cigarettes/day) in the eastcoast cohort as compared with the westcoast cohort [success rate ratio 0.66, 95% confidence interval (95% CI) 0.49-.89; subfertility odds ratio 1.64, 95% CI 0.91-2.91). However, internal analyses within the eastcoast cohort did not show that growing up in a Fishing village or high current Fish consumption decreased the success rate. Eastcoast cohort affiliation showed an increased risk for infertility (odds ratio 2.49, 95% CI 1.05-5.92). CONCLUSIONS: The present data give some support for a negative association between exposure to persistent organochlorine compounds and fertility among heavy smokers. However, when the proxy exposure measures are also considered, the findings are not consistent. Better individual exposure assessments should be used before more firm conclusions are drawn. (Less)
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lowered birth weight among infants born to women with a high intake of Fish contaminated with persistent organochlorine compounds
2000Co-Authors: Lars Rylander, Ulf Stromberg, Lars HagmarAbstract:In Sweden Fatty Fish from the Baltic Sea (at the Swedish east coast) constitute the main exposure route for persistent organochlorine compounds (POC). The present study assessed reproductive outcomes among Fishermen's sisters from the Swedish east coast, who were shown to had had a relatively high consumption of contaminated Fish in early life. For relevant comparison, we used a similar cohort from the Swedish west coast, where the contamination of Fish is considerable less. The east coast cohort women had an increased risk of having an infant with low birth weight (LBW; <2500 g) as compared with the west coast cohort women (odds ratio (OR) 1.6. 95% confidence interval 1.1-2.3). The results strengthen the hypothesized association between exposure to POC during childhood and adolescence and an increased risk for LBW.
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mortality and cancer incidence among women with a high consumption of Fatty Fish contaminated with persistent organochlorine compounds
1995Co-Authors: Lars Rylander, Lars HagmarAbstract:Objectives The purpose of this study was to assess cancer incidence and cardiovascular mortality among women with a high dietary intake of Fatty Fish from the Baltic Sea (on the Swedish east coast), contaminated with persistent organochlorine compounds. Material and methods Cohorts of Fishermen's wives from the Swedish east (1989 subjects) and west (6605 subjects) coasts were established. The mortality and cancer incidence were studied in these cohorts, and comparisons were made with respective regional populations and between the cohorts. Dietary interviews were made with 200 randomly selected cohort women and equally many women from the general population. The interviewed east- and westcoast cohort women ate locally caught Fatty Fish at least twice as often as their referents. Results Compared with that of the regional population, the breast cancer incidence was higher than expected in the eastcoast cohort [standardized incidence ratio (SIR) 1.29, 95% confidence interval (95% CI) 0.96--1.71], whereas it was lower in the westcoast cohort (SIR 0.89; 95% CI 0.77--1.04). When a direct comparison was made between the two cohorts, the eastcoast women displayed an increased breast cancer incidence (incidence rate ratio 1.35, 95% CI 0.98--1.86). No obvious difference was seen between the two cohorts concerning cardiovascular mortality. Conclusion The results support, but do not prove, the hypothesis of an association between exposure to a mixture of persistent organochlorine compounds through Fish consumption and an increased risk for breast cancer.
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Fish consumption and exposure to persistent organochlorine compounds mercury selenium and methylamines among swedish Fishermen
1995Co-Authors: Bg Svensson, Anna Nilsson, E Jonsson, Andrejs Schutz, Bengt Akesson, Lars HagmarAbstract:Objectives This study assessed dietary habits and exposure to selenium, persistent organochlorine compounds, methylmercury, and methylamines among Swedish Fishermen. Methods Two hundred and fifty randomly selected subjects from a cohort of 2896 Fishermen from the Swedish east coast (Baltic Sea) and 8477 Fishermen from the west coast (Skagerrak and Kattegatt) were interviewed along with 250 referents. Subgroups of Fishermen and referents from different coastal areas were also selected for blood and urine sampling. Results The interview data showed that Fishermen ate almost twice as much Fish as the 250 referents from the general population. The blood levels of mercury were twice as high, and the plasma selenium levels were 10-15% higher in the Fishermen than in the referents. There was, however, no difference between the Fishermen's cohorts with respect to these variables. Fishermen from the east coast ate more Fatty Fish than Fishermen from the west coast, and they also had higher blood levels of persistent organochlorine compounds such as polychlorinated biphenyls and polychlorinated dibenzo p-dioxins and furans (present in Fatty Fish species in the Baltic Sea) than both the westcoast Fishermen and the referents. Conclusion A cohort of Swedish eastcoast Fishermen might be a suitable study base for epidemiologic studies on the mortality and cancer morbidity associated with dietary exposure to persistent organochlorine compounds.
Sjurdur F Olsen - One of the best experts on this subject based on the ideXlab platform.
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is high consumption of Fatty Fish during pregnancy a risk factor for fetal growth retardation a study of 44 824 danish pregnant women
2008Co-Authors: Th I Halldorsson, Helle Margrete Meltzer, Inga Thorsdottir, Vibeke Kildegaard Knudsen, Sjurdur F OlsenAbstract:Observational studies point to a positive association between Fish consumption and both birth weight and prolonged gestation. Prolonged gestation has been associated with marine n-3 Fatty acids, in particular, eicosapentaenoic acid and docosahexaenoic acid, in several-but not all-randomized controlled trials. The present study examined the relationship between fetal growth and Fish consumption during pregnancy in 44,824 women from the Danish National Birth Cohort, enrolled during the years 1996-2002. The cohort included about 30% of all deliveries taking place in Denmark during this period. Consumption of total, Fatty, and lean Fish was estimated by a food frequency questionnaire in mid-pregnancy. Birth rates of infants who were below the 10th percentile for gender and gestational age were significantly increased for women consuming more than 60 g of Fish on a daily basis compared with those taking 5 g or less. The adjusted odds ratio was 1.24 (95% confidence interval [CI], 1.03-1.49) for birth weight and 1.21 (95% CI, 1.01-1.43) for head circumference. The adjusted odds ratio for birth length was of borderline significance. Associations with total Fish consumption were accounted for entirely by the consumption of Fatty Fish. Women who ate Fatty Fish at least 4 times per month were significantly more likely than others to give birth to small-for-gestational-age children. Consumption of lean Fish was not associated with any adverse birth outcome. The risk of fetal growth restriction in the offspring of women who reported heavy maternal Fish consumption in this large cohort study was increased approximately 24%. However, almost all this increased risk was associated with Fatty Fish consumption, and thus may be due to exposure to persistent organic pollutants. The investigators suggest that pregnant women be encouraged to consume moderate amounts of Fatty Fish.
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is high consumption of Fatty Fish during pregnancy a risk factor for fetal growth retardation a study of 44 824 danish pregnant women
2007Co-Authors: Th I Halldorsson, Helle Margrete Meltzer, Inga Thorsdottir, Vibeke Kildegaard Knudsen, Sjurdur F OlsenAbstract:The authors examined the relation between Fish consumption during pregnancy and fetal growth among 44,824 women from the Danish National Birth Cohort (1996-2002). They evaluated the associations between consumption of total Fish, Fatty Fish, and lean Fish in midpregnancy and birth weight, birth length, and head circumference among singleton full-term infants. Fish consumption was ascertained by food frequency questionnaire. The birth of infants classified below the 10th percentile for gestational age and gender was significantly increased among women who consumed more than 60 g of Fish per day, as compared with women who consumed 5 g or less per day. Adjusted odds ratios were 1.24 (95% confidence interval (CI): 1.03, 1.49) for birth weight and 1.21 (95% CI: 1.01, 1.43) for head circumference. The adjusted odds ratio was borderline significant for birth length (odds ratio = 1.20, 95% CI: 1.00, 1.45). These increases in risk were followed by small decreases in average values for these growth measures. Furthermore, the inverse association for total Fish consumption could be explained by consumption of Fatty Fish, while no association was found for lean Fish. These results indicate that consumption of Fatty Fish, a known route of exposure to persistent organic pollutants, could be associated with reduced fetal growth.
Ursula Schwab - One of the best experts on this subject based on the ideXlab platform.
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intake of camelina sativa oil and Fatty Fish alter the plasma lipid mediator profile in subjects with impaired glucose metabolism a randomized controlled trial
2020Co-Authors: Topi Meuronen, Arja T Erkkila, Maria Lankinen, Vanessa D De Mello, David E. Laaksonen, Alexander Fauland, Bunichi Shimizu, Craig E Wheelock, Ursula SchwabAbstract:n-3 and n-6 polyunsaturated Fatty acids (PUFAs) and their lipid mediator metabolites are associated with inflammation. We investigated the effect of dietary intake of plant- and animal-derived n-3 PUFAs and Fish protein on the circulatory concentrations of lipid mediators. Seventy-nine subjects with impaired fasting glucose who completed the controlled dietary intervention after randomization to the Fatty Fish (FF, n=20), lean Fish (LF, n=21), Camelina sativa oil (CSO, n=18) or control group (n=20) for 12 weeks were studied. Lipid mediator profiling from fasting plasma samples before and after the intervention was performed by liquid chromatography-mass spectrometry (LC-MS/MS). The FF diet increased concentrations of 18-hydroxyeicosapentaenoic acid (18-HEPE) and 4- and 17-hydroxydocosahexaenoic acid (4-, 17-HDoHE) derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively. Concentrations of lipid mediators derived from α-linolenic acid (ALA) increased and arachidonic acid (AA) derived 5-iso prostaglandin F2α-VI decreased in the CSO group. There were no significant changes in lipid mediators in the LF group. The dietary intake of both plant and animal-based n-3 PUFAs increased circulatory concentrations of lipid mediators with potential anti-inflammatory properties.
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camelina sativa oil Fatty Fish and lean Fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism
2019Co-Authors: Arja T Erkkila, Maria Lankinen, Suvi Manninen, Ho Hang Leung, Vanessa D De Mello, Ursula SchwabAbstract:Dietary Fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if Fatty Fish, lean Fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43-72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, Fatty Fish, lean Fish (four Fish meals/week in both), CSO providing 10 g/day alpha-linolenic acid (ALA), and control diet with limited Fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α , 5-F2t -isoprostanes and 15-F2t -isoprostane metabolites, isofuran, 8-F3t -isoprostanes, and 4-(RS)-4-F4t -neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2 ) collected over 12-h were measured using liquid chromatography tandem-mass spectrometry. Plasma phospholipid Fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p-value <0.001). In the Fatty Fish group, proportions of eicosapentaenoic and docosahexaenoic acids increased (overall p-value <0.001 for both). Prostaglandin F2α was higher in the CSO group than in the control group (p < 0.05), however, there were no other significant changes in urinary excretion of other prostanoids among the study groups. At baseline, arachidonic acid in plasma phospholipids was positively (r = 0.247, p < 0.05) and ALA negatively (r = -0.326, p < 0.05) associated with urinary total isoprostanes. In conclusion, CSO, Fatty Fish, and lean Fish consumption do not cause major changes in oxidative stress markers in subjects with impaired glucose tolerance.
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Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism-A Randomized Controlled Trial.
2018Co-Authors: Ursula Schwab, Maria Lankinen, Vanessa D De Mello, Suvi M. Manninen, Sudhir Kurl, Kari Pulkki, David E. Laaksonen, Arja T ErkkilaAbstract:SCOPE The aim of the study is to examine whether lean Fish (LF), Fatty Fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four Fish meals/week), LF (four Fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of Fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
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nontargeted metabolite profiling discriminates diet specific biomarkers for consumption of whole grains Fatty Fish and bilberries in a randomized controlled trial
2015Co-Authors: Kati Hanhineva, Maria Lankinen, Vanessa D De Mello, Ursula Schwab, Anna Pedret, Marjukka Kolehmainen, Jussi Paananen, Rosa Sola, Marko Lehtonen, Kaisa PoutanenAbstract:BACKGROUND Nontargeted metabolite profiling allows for concomitant examination of a wide range of metabolite species, elucidating the metabolic alterations caused by dietary interventions. OBJECTIVE The aim of the current study was to investigate the effects of dietary modifications on the basis of increasing consumption of whole grains, Fatty Fish, and bilberries on plasma metabolite profiles to identify applicable biomarkers for dietary intake and endogenous metabolism. METHODS Metabolite profiling analysis was performed on fasting plasma samples collected in a 12-wk parallel-group intervention with 106 participants with features of metabolic syndrome who were randomly assigned to 3 dietary interventions: 1) whole-grain products, Fatty Fish, and bilberries [healthy diet (HD)]; 2) a whole-grain-enriched diet with the same grain products as in the HD intervention but with no change in Fish or berry consumption; and 3) refined-wheat breads and restrictions on Fish and berries (control diet). In addition, correlation analyses were conducted with the food intake data to define the food items correlating with the biomarker candidates. RESULTS Nontargeted metabolite profiling showed marked differences in fasting plasma after the intervention diets compared with the control diet. In both intervention groups, a significant increase was observed in 2 signals identified as glucuronidated alk(en)-ylresorcinols [corrected P value (Pcorr) < 0.05], which correlated strongly with the intake of whole-grain products (r = 0.63, P < 0.001). In addition, the HD intervention increased the signals for furan Fatty acids [3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF)], hippuric acid, and various lipid species incorporating polyunsaturated Fatty acids (Pcorr < 0.05). In particular, plasma CMPF correlated strongly with the intake of Fish (r = 0.47, P < 0.001) but not with intakes of any other foods. CONCLUSIONS Novel biomarkers of the intake of health-beneficial food items included in the Nordic diet were identified by the metabolite profiling of fasting plasma and confirmed by the correlation analyses with dietary records. The one with the most potential was CMPF, which was shown to be a highly specific biomarker for Fatty Fish intake. This trial was registered at clinicaltrials.gov as NCT00573781.
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a diet high in Fatty Fish bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial the sysdimet study
2011Co-Authors: V D F De Mello, Ursula Schwab, Marjukka Kolehmainen, Kaisa Poutanen, Wolfgang Koenig, Maritta Siloaho, Hannu Mykkanen, Matti UusitupaAbstract:Aims/hypothesis Low-grade inflammation and endothelial dysfunction may play a role in the pathogenesis of type 2 diabetes and cardiovascular disease. We evaluated whether a diet high in Fatty Fish, bilberries and wholegrain products (Healthy Diet) improves biomarkers reflecting inflammation and endothelial dysfunction in individuals with impaired glucose metabolism.
Santiago P Aubourg - One of the best experts on this subject based on the ideXlab platform.
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effectiveness of a combined ethanol aqueous extract of alga cystoseira compressa for the quality enhancement of a chilled Fatty Fish species
2018Co-Authors: Hanane Oucif, Jorge Barrosvelazquez, Jose M Miranda, Smail Ali Mehidi, Sidimohamed Elamine Abiayad, Santiago P AubourgAbstract:Seaweeds have attracted an increasing attention as a new source for bioactive compounds, these include preservative compounds. This study is a first attempt to employ alga Cystoseira compressa for the preservation of chilled Fish. For it, a combined ethanol–aqueous extract of this alga was included in the icing system and employed as chilling medium for the storage of horse mackerel (Trachurus trachurus) for 11 days. On the basis of the microbial groups (aerobes, psychrotrophs, proteolytic, lipolytic and Enterobacteriaceae bacteria) assessed, an inhibitory effect (p < 0.05) on microbial activity in horse mackerel muscle was observed as a result of including the alga extract in the icing medium; such preservative effect was also proved by chemical determinations related to microbial activity (pH and trimethylamine values). Additionally, a significant decrease (p < 0.05) of lipid hydrolysis (free Fatty acids formation) and oxidation (fluorescent compounds formation) in Fish was also observed as a result of the presence of C. compressa extracts in the icing medium. The icing medium proposed in this work (i.e., the combination of ethanolic and aqueous extracts of C. compressa) may constitute a promising strategy to the application of natural algae extracts for Fatty Fish storage and enhance quality retention during commercialisation.
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lipid hydrolysis and oxidation development in frozen mackerel scomber scombrus effect of a high hydrostatic pressure pre treatment
2013Co-Authors: Manuel Vazquez, Antonio J Torres, Jose Manuel Gallardo, Jorge A Saraiva, Santiago P AubourgAbstract:Abstract This work focused on assessing lipid damage during the storage of frozen Atlantic mackerel ( Scomber scombrus ) subjected to a high hydrostatic pressure (HHP) treatment (150, 300, 450 MPa with holding times of 0.0, 2.5, and 5.0 min) prior to freezing. The extent of lipid hydrolysis (free Fatty acids) and oxidation (peroxide, thiobarbituric acid reactive substance and fluorescent and browning compound formation) as well as the polyene content were analysed during 3 months of accelerated storage at − 10 °C. A marked inhibition (p 0.05) in the content of primary and secondary oxidation compounds were observed. Industrial relevance Frozen storage of Fatty Fish species is known to be strongly limited by the lipid damage development, being this an important drawback for its commercialisation as such or for its further employment as raw material in other kinds of processing (canneries, smoking, etc.). Present research provides novel and valuable information concerning the employment of high hydrostatic pressure technology to inhibit lipid damage (hydrolysis and oxidation) during the further frozen storage of mackerel ( Scomber scombrus ). Thus, pressure (150, 300 and 450 MPa) and holding time (0.0, 2.5 and 5.0 min) conditions tested showed to be profitable to partially inhibit lipid damage.
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rancidity development in frozen pelagic Fish influence of slurry ice as preliminary chilling treatment
2007Co-Authors: Vanesa Losada, Jorge Barrosvelazquez, Santiago P AubourgAbstract:Abstract The slurry ice technology has shown profitable advantages when employed instead of traditional flake ice for the manufacture of chilled aquatic species. The present work is aimed at evaluating the effect of slurry ice as a preliminary treatment prior to frozen storage. For it, specimens of a small pelagic Fatty Fish species (sardine; Sardina pilchardus) were stored in slurry ice for 2, 5 and 9 days, then subjected to freezing (–80 °C; 24 h) and finally kept frozen (−20 °C) during 1, 2 and 4 months. At such times, rancidity development in frozen sardine was measured by sensory (odour, skin, colour and flesh appearance) and biochemical (lipid hydrolysis and oxidation) analyses and compared to a control batch previously chilled in flake ice. Sensory analysis indicated an extended shelf-life time for frozen sardine that was preliminary stored under slurry ice for 2, 5 or 9 days, as compared to their counterparts subjected to flake icing. Sensory results were corroborated ( P 0.05 ) by biochemical lipid oxidation indices (thiobarbituric acid reactive substances and the fluorescence formation). The present work opens the way to the use of slurry ice instead of flake ice as preliminary treatment of Fish material prior to the frozen storage.
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development of lipid changes related to quality loss during the frozen storage of farmed coho salmon oncorhynchus kisutch
2007Co-Authors: Alicia Rodriguez, Vanesa Losada, Julia Vinagre, Angelica M Larrain, Vilma Quitral, Santiago P AubourgAbstract:Lipid changes related to quality loss were evaluated during frozen storage of coho salmon for up to 15 months. Biochemical indices concerning lipid hydrolysis (free Fatty acids, FFA) and oxidation (peroxide value, PV; thiobarbituric acid index, TBA-i; fluorescent compounds, FR; polyene index, PI) were determined and compared to sensory (odor and taste) and endogenous antioxidant (tocopherol isomers and astaxanthin) assessments. As a result of the frozen storage, lipid hydrolysis was shown to develop according to the increase in FFA content (p < 0.05). However, most biochemical lipid oxidation indices (PV, TBA-i and FR) led to a low degree of rancidity development (p < 0.05) when compared to other Fatty Fish species under similar frozen storage conditions. The PI value decreased (p < 0.05) at month 10 but then remained unchanged until the end of the experiment. Rancid odor and taste development were shown to be low throughout the experiment, according to the biochemical indices mentioned above. However, a progressive decrease (p < 0.05) in the original fresh odor and taste of salmon Fish flesh occurred with increasing frozen storage time, such that Fish samples had the poorest scores by month 15. Endogenous antioxidants were remarkably stable throughout the experiment and which might contribute to the oxidative stability of frozen farmed coho salmon lipids.
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rancidity development during the chilled storage of farmed coho salmon oncorhynchus kisutch
2005Co-Authors: Santiago P Aubourg, Vanesa Losada, Julia Vinagre, Alicia Rodriguez, Angelica M Larrain, Vilma Quitral, Julio Gomez, Liliana Maier, Emma WittigAbstract:Coho salmon (Oncorhynchus kisutch) is a Fatty Fish species whose farming production has greatly increased in recent years. Lipid damage produced during Coho salmon chilled storage was studied for up to 24 d. Lipid hydrolysis (free Fatty acids, FFA) and oxidation (conjugated dienes; peroxide value, PV; thiobarbituric acid index, TBA-i; fluorescent compounds formation, FR; browning development) were determined and compared to lipid composition (polyene index, PI; astaxanthin, AX) changes and sensory assessment (rancid odour development) results. Most lipid damage indices developed slowly during storage; thus, values obtained for FFA, PV, TBA-i and FR were in all cases under 1.5 g/100 g, 4.0 meq oxygen/kg lipid, 0.40 mg malondialdehyde/kg muscle and 0.40, respectively. Odour assessment showed a significant (p <0.05) rancidity development at day 10, when compared to starting Fish material; then, non-acceptable values were obtained at days 19 and 24. The PI analysis showed not many differences during the storage time, with the lowest mean value at day 19. AX analysis indicated a relatively high content in the white muscle, which was maintained till the end of the experiment. A low oxidation development is concluded for Coho salmon lipids when compared to other Fatty Fish species under the same chilling conditions. AX was found to contribute to the oxidation stability of Coho salmon lipids, due to its free radical scavenger properties.
