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Quentin J Clemens - One of the best experts on this subject based on the ideXlab platform.
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the prevalence and overlap of Interstitial Cystitis bladder pain syndrome and chronic prostatitis chronic pelvic pain syndrome in men results of the rand Interstitial Cystitis epidemiology male study
The Journal of Urology, 2013Co-Authors: Anne M Suskind, Marika J Suttorp, Marc N Elliott, Sandra H Berry, Brett Ewing, Quentin J ClemensAbstract:Purpose: As part of the RICE (RAND Interstitial Cystitis Epidemiology) study, we developed validated case definitions to identify Interstitial Cystitis/bladder pain syndrome in women and chronic prostatitis/chronic pelvic pain syndrome in men. Using population based screening methods, we applied these case definitions to determine the prevalence of these conditions in men.Materials and Methods: A total of 6,072 households were contacted by telephone to screen for men who had symptoms of Interstitial Cystitis/bladder pain syndrome or chronic prostatitis/chronic pelvic pain syndrome. An initial 296 men screened positive, of whom 149 met the inclusionary criteria and completed the telephone interview. For Interstitial Cystitis/bladder pain syndrome 2 case definitions were applied (1 with high sensitivity and 1 with high specificity), while for chronic prostatitis/chronic pelvic pain syndrome a single case definition (with high sensitivity and specificity) was used. These case definitions were used to classif...
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comparison of an Interstitial Cystitis bladder pain syndrome clinical cohort with symptomatic community women from the rand Interstitial Cystitis epidemiology study
The Journal of Urology, 2012Co-Authors: Katy S Konkle, Marika J Suttorp, Marc N Elliott, Sandra H Berry, Daniel J Clauw, Lara Hilton, Quentin J ClemensAbstract:Purpose: The RAND Interstitial Cystitis Epidemiology survey estimated that 2.7% to 6.5% of United States women have urinary symptoms consistent with a diagnosis of Interstitial Cystitis/bladder pain syndrome. We describe the demographic and clinical characteristics of the symptomatic community based RAND Interstitial Cystitis Epidemiology cohort, and compare them with those of a clinically based Interstitial Cystitis/bladder pain syndrome cohort.Materials and Methods: Subjects included 3,397 community women who met the criteria for the RAND Interstitial Cystitis Epidemiology high sensitivity case definition, and 277 women with an Interstitial Cystitis/bladder pain syndrome diagnosis recruited from specialist practices across the United States (clinical cohort). Questions focused on demographic information, symptom severity, quality of life indicators, concomitant diagnoses and treatment.Results: Average symptom duration for both groups was approximately 14 years. Women in the clinical cohort reported wors...
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prevalence of symptoms of bladder pain syndrome Interstitial Cystitis among adult females in the united states
The Journal of Urology, 2011Co-Authors: Sandra H Berry, Quentin J Clemens, Laura M Bogart, Marika J Suttorp, Marc N Elliott, Leroy M Nyberg, Michael A Stoto, Paul W EggersAbstract:Purpose: Bladder pain syndrome/Interstitial Cystitis is a poorly understood condition that can cause serious disability. We provide the first population based symptom prevalence estimate to our knowledge among United States adult females.Materials and Methods: We developed and validated 2 case definitions to identify bladder pain syndrome/Interstitial Cystitis symptoms. Beginning in August 2007 we telephoned United States households, seeking adult women with bladder symptoms or a bladder pain syndrome/Interstitial Cystitis diagnosis. Second stage screening identified those subjects who met case definition criteria. Each completed a 60-minute interview on the severity and impact of bladder symptoms, health care seeking and demographics. Data collection ended in April 2009. Using population and nonresponse weights we calculated prevalence estimates based on definitions spanning a range of sensitivity and specificity. We used United States Census counts to estimate the number of affected women in 2006. The r...
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aua guideline for the diagnosis and treatment of Interstitial Cystitis bladder pain syndrome
The Journal of Urology, 2011Co-Authors: Philip M Hanno, Deborah R Erickson, Quentin J Clemens, David Burks, John B Forrest, Roger Dmochowski, Mary P Fitzgerald, Barbara Gordon, Mikel Gray, Robert D MayerAbstract:Purpose: To provide a clinical framework for the diagnosis and treatment of Interstitial Cystitis/bladder pain syndrome.Materials and Methods: A systematic review of the literature using the MEDLINE® database (search dates 1/1/83-7/22/09) was conducted to identify peer reviewed publications relevant to the diagnosis and treatment of Interstitial Cystitis/bladder pain syndrome. Insufficient evidence-based data were retrieved regarding diagnosis and, therefore, this portion of the Guideline is based on Clinical Principles and Expert Opinion statements. The review yielded an evidence base of 86 treatment articles after application of inclusion/exclusion criteria. These publications were used to create the majority of the treatment portion of the Guideline. When sufficient evidence existed, the body of evidence for a particular treatment was assigned a strength rating of A (high), B (moderate) or C (low). Additional treatment information is provided as Clinical Principles and Expert Opinion when insufficient ...
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prevalence and correlates of sexual dysfunction among women with bladder pain syndrome Interstitial Cystitis
Urology, 2011Co-Authors: Laura M Bogart, Quentin J Clemens, Marika J Suttorp, Marc N Elliott, Sandra H BerryAbstract:Objectives To examine the prevalence and correlates of general and bladder pain syndrome/Interstitial Cystitis (BPS/IC)-specific sexual dysfunction among women in the RAND Interstitial Cystitis Epidemiology study using a probability sample survey of U.S. households. Sexual dysfunction can contribute to a reduced quality of life for women with bladder pain syndrome/Interstitial Cystitis (BPS/IC). Methods We telephoned 146 231 households to identify women who reported bladder symptoms or a BPS/IC diagnosis. Those who reported either underwent a second-stage screening using the RAND Interstitial Cystitis Epidemiology study high-specificity symptom criteria. The criteria were pain, pressure, or discomfort in pelvic area; daytime urinary frequency ≥10 times or urgency due to pain, pressure, or discomfort (not fear of wetting); pain that worsened as the bladder filled; bladder symptoms did not resolve after antibiotic treatment; and patients never treated with hormone injections for endometriosis. Women who met the RAND Interstitial Cystitis Epidemiology criteria (n = 1469) completed measures of BPS/IC-specific and general sexual dysfunction symptoms, bladder symptom severity, general physical health, depression, medical care-seeking, and sociodemographic characteristics. Results Of those with a current sexual partner (75%), 88% reported ≥1 general sexual dysfunction symptom and 90% reported ≥1 BPS/IC-specific sexual dysfunction symptom in the past 4 weeks. In the multivariate models, BPS/IC-specific sexual dysfunction was significantly associated with more severe BPS/IC symptoms, younger age, worse depression symptoms, and worse perceived general health. Multivariate correlates of general sexual dysfunction included non-Latino race/ethnicity, being married, and having depression symptoms. Conclusions The results of our study have shown that women with BPS/IC symptoms experience very high levels of sexual dysfunction. Also, sexual dysfunction covaries with symptoms.
Philip M Hanno - One of the best experts on this subject based on the ideXlab platform.
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Interstitial Cystitis bladder pain syndrome the evolving landscape animal models and future perspectives
International Journal of Urology, 2020Co-Authors: Daichi Maeda, Yoshiyuki Akiyama, Philip M Hanno, Yi Luo, Yukio HommaAbstract:Interstitial Cystitis/bladder pain syndrome is a debilitating condition of unknown etiology characterized by persistent pelvic pain with lower urinary tract symptoms and comprises a wide variety of potentially clinically useful phenotypes with different possible etiologies. Current clinicopathological and genomic evidence suggests that Interstitial Cystitis/bladder pain syndrome should be categorized by the presence or absence of Hunner lesions, rather than by clinical phenotyping based on symptomatology. The Hunner lesion subtype is a distinct inflammatory disease with proven bladder etiology characterized by epithelial denudation and enhanced immune responses frequently accompanied by clonal expansion of infiltrating B cells, with potential engagement of infection. Meanwhile, the non-Hunner lesion subtype is a non-inflammatory disorder with little evidence of bladder etiology. It is potentially associated with urothelial malfunction and neurophysiological dysfunction, and frequently presents with somatic and/or psychological symptoms, that commonly result in central nervous sensitization. Animal models of autoimmune Cystitis and neurogenic sensitization might serve as disease models for the Hunner lesion and non-Hunner lesion subtypes, respectively. Here, we revisit the taxonomy of Interstitial Cystitis/bladder pain syndrome according to current research, and discuss its potential pathophysiology and representative animal models. Categorization of Interstitial Cystitis/bladder pain syndrome based on cystoscopy is mandatory to design optimized treatment and research strategies for each subtype. A tailored approach that specifically targets the characteristic inflammation and epithelial denudation for the Hunner lesion subtype, or the urothelial malfunction, sensitized/altered nervous system and psychosocial problems for the non-Hunner lesion subtype, is essential for better clinical management and research progress in this complex condition.
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phenotyping of Interstitial Cystitis bladder pain syndrome
International Journal of Urology, 2019Co-Authors: Yoshiyuki Akiyama, Philip M HannoAbstract:Interstitial Cystitis/bladder pain syndrome is a chronic, potentially debilitating condition characterized by pain perceived to be related to the bladder in conjunction with lower urinary tract symptoms, and includes a wide variety of clinical phenotypes with diverse etiologies. Currently the only clinically relevant proven phenotype of Interstitial Cystitis/bladder pain syndrome is the Hunner lesion. Whether the presence of Hunner lesions is a hallmark of a distinct disease cohort or a potentially transient feature of non-Hunner lesion phenotype has been debated but remains controversial. There are few documented examples of a patient converting between the two forms. Growing clinical and basic evidence supports eliminating the Hunner lesion phenotype from the bladder pain syndrome umbrella and considering it a distinct disease. The Hunner lesion phenotype is characterized by distinct bladder histology, including subepithelial chronic inflammatory changes and epithelial denudation, and specific clinical characteristics (older onset age, severe bladder-centric symptoms, reduced bladder capacity, and favorable response to the lesion-targeted therapies). To define the Hunner lesion phenotype, it is necessary to develop an atlas of standardized images of cystoscopic (and, if possible, pathological) appearances of Hunner lesions. A true potential and clinically relevant phenotype of Interstitial Cystitis/bladder pain syndrome may be patients with non-bladder-centric symptoms, characterized by the affect dysregulation and somatic symptoms, and a greater bladder capacity in absence of Hunner lesions. In the present workshop, we concluded that the Hunner lesion is a valid phenotype and can reasonably be considered a disease in its own right. Assessment of bladder capacity and the extent of symptoms (bladder beyond or bladder centric) may help phenotyping of Interstitial Cystitis/bladder pain syndrome. Proper phenotyping is essential for the diagnosis and treatment of Interstitial Cystitis/bladder pain syndrome, and for facilitating research.
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aua guideline for the diagnosis and treatment of Interstitial Cystitis bladder pain syndrome
The Journal of Urology, 2011Co-Authors: Philip M Hanno, Deborah R Erickson, Quentin J Clemens, David Burks, John B Forrest, Roger Dmochowski, Mary P Fitzgerald, Barbara Gordon, Mikel Gray, Robert D MayerAbstract:Purpose: To provide a clinical framework for the diagnosis and treatment of Interstitial Cystitis/bladder pain syndrome.Materials and Methods: A systematic review of the literature using the MEDLINE® database (search dates 1/1/83-7/22/09) was conducted to identify peer reviewed publications relevant to the diagnosis and treatment of Interstitial Cystitis/bladder pain syndrome. Insufficient evidence-based data were retrieved regarding diagnosis and, therefore, this portion of the Guideline is based on Clinical Principles and Expert Opinion statements. The review yielded an evidence base of 86 treatment articles after application of inclusion/exclusion criteria. These publications were used to create the majority of the treatment portion of the Guideline. When sufficient evidence existed, the body of evidence for a particular treatment was assigned a strength rating of A (high), B (moderate) or C (low). Additional treatment information is provided as Clinical Principles and Expert Opinion when insufficient ...
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sexual function is a determinant of poor quality of life for women with treatment refractory Interstitial Cystitis
The Journal of Urology, 2007Co-Authors: Curtis J Nickel, Christopher K Payne, Philip M Hanno, Kathleen J Propert, Dean A Tripp, Valerie Teal, David Burks, Harris E Foster, Robert J Mayer, Kenneth M PetersAbstract:Purpose: Interstitial Cystitis significantly negatively impacts quality of life. The demographic and clinical factors associated with decreased quality of life in these patients have not been well studied.Materials and Methods: Women with moderate/severe Interstitial Cystitis enrolled in a clinical trial of intravesical bacillus Calmette-Guerin were studied. Demographic data and responses to questionnaires were evaluated at baseline, including the O’Leary-Sant Interstitial Cystitis Symptom Index and Problem Index, University of Wisconsin Interstitial Cystitis Inventory, Medical Outcomes Study sexual functioning scale, and the physical composite and mental composite scales of the Medical Outcomes Study Short Form Health Status Survey. Three composite indexes were constructed (from the O’Leary-Sant Interstitial Cystitis Symptom Index, O’Leary-Sant Interstitial Cystitis Problem Index, pain/urgency Likert scales and 24-hour voiding diary) to document the severity, frequency and bother of pain, urinary urgency...
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a randomized controlled trial of intravesical bacillus calmette guerin for treatment refractory Interstitial Cystitis
The Journal of Urology, 2005Co-Authors: Robert J Mayer, Kenneth M Peters, Christopher K Payne, Philip M Hanno, Kathleen J Propert, David Burks, Yawei Zhang, Daniel J Culkin, Ananias C Diokno, Richard J LandisAbstract:ABSTRACTPurpose: We compared intravesical bacillus Calmette-Guerin (BCG) to placebo instillations in patients with treatment refractory Interstitial Cystitis (IC).Materials and Methods: Subjects wh...
Yukio Homma - One of the best experts on this subject based on the ideXlab platform.
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clinical guidelines for Interstitial Cystitis bladder pain syndrome
International Journal of Urology, 2020Co-Authors: Yukio Homma, Tomohiro Ueda, Hikaru Tomoe, Alex T.l. Lin, Yoshiyuki Akiyama, Akira Furuta, Daichi Maeda, Hann Chorng Kuo, Ming Huei Lee, Joon Chul KimAbstract:The clinical guidelines for Interstitial Cystitis and related symptomatic conditions were revised by updating our previous guidelines. The current guidelines define Interstitial Cystitis/bladder pain syndrome as a condition with chronic pelvic pain, pressure or discomfort perceived to be related to the urinary bladder accompanied by other urinary symptoms, such as persistent urge to void or urinary frequency in the absence of confusable diseases. The characteristic symptom complex is collectively referred as hypersensitive bladder symptoms. Interstitial Cystitis/bladder pain syndrome is divided into Hunner-type Interstitial Cystitis and bladder pain syndrome; Hunner-type Interstitial Cystitis and bladder pain syndrome represent Interstitial Cystitis/bladder pain syndrome with Hunner lesions and Interstitial Cystitis/bladder pain syndrome without Hunner lesions, respectively. So-called non-Hunner-type Interstitial Cystitis featured by glomerulations or bladder bleeding after distension is included in bladder pain syndrome. The symptoms are virtually indistinguishable between Hunner-type Interstitial Cystitis and bladder pain syndrome; however, Hunner-type Interstitial Cystitis and bladder pain syndrome should be considered as a separate entity of disorder. Histopathology totally differs between Hunner-type Interstitial Cystitis and bladder pain syndrome; Hunner-type Interstitial Cystitis is associated with severe inflammation of the urinary bladder accompanied by lymphoplasmacytic infiltration and urothelial denudation, whereas bladder pain syndrome shows little pathological changes in the bladder. Pathophysiology would also differ between Hunner-type Interstitial Cystitis and bladder pain syndrome, involving interaction of multiple factors, such as inflammation, autoimmunity, infection, exogenous substances, urothelial dysfunction, neural hyperactivity and extrabladder disorders. The patients should be treated differently based on the diagnosis of Hunner-type Interstitial Cystitis or bladder pain syndrome, which requires cystoscopy to determine the presence or absence Hunner lesions. Clinical studies are to be designed to analyze outcomes separately for Hunner-type Interstitial Cystitis and bladder pain syndrome.
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Interstitial Cystitis bladder pain syndrome the evolving landscape animal models and future perspectives
International Journal of Urology, 2020Co-Authors: Daichi Maeda, Yoshiyuki Akiyama, Philip M Hanno, Yi Luo, Yukio HommaAbstract:Interstitial Cystitis/bladder pain syndrome is a debilitating condition of unknown etiology characterized by persistent pelvic pain with lower urinary tract symptoms and comprises a wide variety of potentially clinically useful phenotypes with different possible etiologies. Current clinicopathological and genomic evidence suggests that Interstitial Cystitis/bladder pain syndrome should be categorized by the presence or absence of Hunner lesions, rather than by clinical phenotyping based on symptomatology. The Hunner lesion subtype is a distinct inflammatory disease with proven bladder etiology characterized by epithelial denudation and enhanced immune responses frequently accompanied by clonal expansion of infiltrating B cells, with potential engagement of infection. Meanwhile, the non-Hunner lesion subtype is a non-inflammatory disorder with little evidence of bladder etiology. It is potentially associated with urothelial malfunction and neurophysiological dysfunction, and frequently presents with somatic and/or psychological symptoms, that commonly result in central nervous sensitization. Animal models of autoimmune Cystitis and neurogenic sensitization might serve as disease models for the Hunner lesion and non-Hunner lesion subtypes, respectively. Here, we revisit the taxonomy of Interstitial Cystitis/bladder pain syndrome according to current research, and discuss its potential pathophysiology and representative animal models. Categorization of Interstitial Cystitis/bladder pain syndrome based on cystoscopy is mandatory to design optimized treatment and research strategies for each subtype. A tailored approach that specifically targets the characteristic inflammation and epithelial denudation for the Hunner lesion subtype, or the urothelial malfunction, sensitized/altered nervous system and psychosocial problems for the non-Hunner lesion subtype, is essential for better clinical management and research progress in this complex condition.
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clinical guidelines for Interstitial Cystitis and hypersensitive bladder updated in 2015
International Journal of Urology, 2016Co-Authors: Yukio Homma, Tomohiro Ueda, Hikaru Tomoe, Alex T.l. Lin, Hann Chorng Kuo, Ming Huei Lee, Joon Chul Kim, Kyusung LeeAbstract:Clinical guidelines for Interstitial Cystitis and hypersensitive bladder have been updated as of 2015. The guidelines define Interstitial Cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) and bladder pathology, after excluding other diseases explaining symptoms. Interstitial Cystitis is further classified by bladder pathology; either Hunner type Interstitial Cystitis with Hunner lesions or non-Hunner type Interstitial Cystitis with mucosal bleeding after distension in the absence of Hunner lesions. Hypersensitive bladder refers to a condition, where hypersensitive bladder symptoms are present, but bladder pathology or other explainable diseases are unproven. Interstitial Cystitis and hypersensitive bladder severely affect patients' quality of life as a result of disabling symptoms and/or comorbidities. Reported prevalence suggestive of these disorders varies greatly from 0.01% to >6%. Pathophysiology would be an interaction of multiple factors including urothelial dysfunction, inflammation, neural hyperactivity, exogenous substances and extrabladder disorders. Definite diagnosis of Interstitial Cystitis and hypersensitive bladder requires cystoscopy with or without hydrodistension. Most of the therapeutic options lack a high level of evidence, leaving a few as recommended therapeutic options.
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measurement of oxyhemoglobin concentration changes in Interstitial Cystitis female patients a near infrared spectroscopy study
International Journal of Urology, 2015Co-Authors: Shinya Matsumoto, Shinichi Matsumoto, Yukio HommaAbstract:Objectives To investigate brain activity related to bladder sensation in Interstitial Cystitis patients. Methods A total of 10 Interstitial Cystitis patients (all women; mean age 68 years) and 10 healthy controls (all women; mean age 64 years) participated in the present study. Frontal lobe blood flow was measured non-invasively by using multichannel near-infrared spectroscopy with large and small bladder volumes (created by infusing water) up to the first desire to void. Results The frontal cortex of the right and left hemisphere was activated, and the activation was detected as an increase in oxyhemoglobin concentration. The increase during the first desire to void in the Interstitial Cystitis group was greater than that in the control group. In addition, this difference was particularly observed in Brodmann's areas 9, 44, 45 and 46, reportedly associated with micturition and sensory modulation. Conclusions The present study shows that the frontal area is largely activated during bladder filling in Interstitial Cystitis patients. Our findings suggest that the major change in cerebral blood flow is related to the characteristic urinary symptoms of Interstitial Cystitis patients.
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a case of bladder cancer arising after augmentation cystoplasty using ileal patch for Interstitial Cystitis
Hinyokika kiyo. Acta urologica Japonica, 2014Co-Authors: Jinpei Kumagai, Hisashi Matsushima, Shinichiro Murayama, Munehiro Yokoyama, Yukio HommaAbstract:A 62-year-old man, who was refractory to repeated hydrodistentions for Interstitial Cystitis, underwent augmentation cystoplasty using ileal patch. Pathological examination revealed no malignancy. Computed tomography (CT) scan showed multiple pelvic and para-aortic lymph-node swellings at 14 months after the operation. CT-guided lymph-nodes biopsies and transurethral bladder biopsies revealed invasive urothelial carcinoma with lymph node metastasis. In patients with symptoms of Interstitial Cystitis, bladder cancer should be kept in mind despite negative findings of cytology and bladder biopsies.
Curtis J Nickel - One of the best experts on this subject based on the ideXlab platform.
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clinical phenotyping does not differentiate hunner lesion subtype of Interstitial Cystitis bladder pain syndrome a relook at the role of cystoscopy
The Journal of Urology, 2016Co-Authors: Christopher R Doiron, Karen Irvinebird, Victoria Tolls, Kerrilynn Kelly, Curtis J NickelAbstract:Purpose: Identifying Hunner lesions in patients with Interstitial Cystitis/bladder pain syndrome presents an opportunity for objective classification into Hunner lesion Interstitial Cystitis/bladder pain syndrome (classic Interstitial Cystitis) and nonHunner lesion bladder pain syndrome. While currently the former diagnosis requires cystoscopy, limited data suggest that these subtypes can be distinguished without endoscopy based on the degree of bladder focused centricity and the infrequent association with generalized pain conditions.Materials and Methods: Patients in a prospective, single center database of Interstitial Cystitis/bladder pain syndrome who had documented cystoscopic findings were categorized with Hunner lesion Interstitial Cystitis/bladder pain syndrome or nonHunner lesion bladder pain syndrome. Demographics, pain and symptom scores, voiding symptoms, irritable bowel syndrome and clinical UPOINT (urinary, psychosocial, organ specific, infection, neurological and tenderness) scoring were c...
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tanezumab reduces pain in women with Interstitial Cystitis bladder pain syndrome and patients with nonurological associated somatic syndromes
The Journal of Urology, 2016Co-Authors: Curtis J Nickel, Ian W Mills, Tim J Crook, Anamaria Jorga, Gary A Atkinson, Michael D. Smith, John N KriegerAbstract:Purpose: We performed pooled analyses from 3 small, clinical trials of tanezumab in patients with urological chronic pelvic pain, including chronic prostatitis/chronic pelvic pain syndrome and Interstitial Cystitis/bladder pain syndrome, to identify patient subpopulations more likely to benefit from tanezumab treatment.Materials and Methods: Pooled analyses included data from 208 patients with Interstitial Cystitis/bladder pain syndrome or chronic prostatitis/chronic pelvic pain syndrome randomized to placebo (104, 65 [62.5%] female) or tanezumab (104, 63 [60.6%] female) who received 1 dose or more of study medication. Data on tanezumab were from study A4091010 (Interstitial Cystitis/bladder pain syndrome) on 200 μg/kg intravenous, study A4091019 (chronic prostatitis/chronic pelvic pain syndrome) on 20 mg intravenous and study A4091035 (Interstitial Cystitis/bladder pain syndrome) on 20 mg subcutaneous. Primary study end points were evaluated using analysis of covariance with gender, study and baseline pa...
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clinical and psychological parameters associated with pain pattern phenotypes in women with Interstitial Cystitis bladder pain syndrome
The Journal of Urology, 2015Co-Authors: Curtis J Nickel, Dean A TrippAbstract:Purpose: It was recently suggested that 2 distinct clinical phenotypes can be described in patients with urological chronic pelvic pain syndrome, including pelvic pain only and pelvic pain beyond. We examined data on patients with Interstitial Cystitis/bladder pain syndrome, including body pain location mapping, and associated medical and psychosocial phenotyping to validate these body pain maps in a cohort of female patients with Interstitial Cystitis/bladder pain syndrome undergoing tertiary care.Materials and Methods: Validated questionnaires from 173 diagnosed outpatient female patients with Interstitial Cystitis/bladder pain syndrome included a body pain area diagram, demographics/history, pain assessment, Interstitial Cystitis/bladder pain syndrome symptoms, depression, anxiety, stress, fatigue, sexual functioning, catastrophizing, quality of life and data on other chronic pain conditions. Two pain phenotypes based on counts of body locations, pelvic pain only and pelvic pain beyond, were comprehens...
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Interstitial Cystitis painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome fibromyalgia and chronic fatigue syndrome
The Journal of Urology, 2010Co-Authors: Curtis J Nickel, Claire C Yang, Michel A Pontari, Dean A Tripp, Robert J Mayer, Lesley K Carr, Raggi Doggweiler, Nagendra Mishra, Robert Moldwin, J NordlingAbstract:Purpose: We characterized and compared the impact of clinical phenotypic associations between Interstitial Cystitis/painful bladder syndrome and controls in relation to potentially related conditions, particularly irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.Materials and Methods: Female patients with Interstitial Cystitis/painful bladder syndrome and controls with no Interstitial Cystitis/painful bladder syndrome completed a biopsychosocial phenotyping questionnaire battery which included demographics/history form, self-reported history of associated conditions, and 10 validated questionnaires focused on symptoms, suffering/coping and behavioral/social factors.Results: Questionnaires were completed by 205 patients with Interstitial Cystitis/painful bladder syndrome and 117 controls matched for age. Prevalence of self-reported associated condition diagnosis in Interstitial Cystitis/painful bladder syndrome vs controls was irritable bowel syndrome 38.6% vs 5.2%, fibromyalgia 17.7% vs...
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psychosocial phenotyping in women with Interstitial Cystitis painful bladder syndrome a case control study
The Journal of Urology, 2010Co-Authors: Curtis J Nickel, Robert Moldwin, Claire C Yang, Michel A Pontari, Dean A Tripp, Robert J Mayer, Lesley K Carr, Raggi Doggweiler, Nagendra Mishra, J NordlingAbstract:Purpose: We characterized and compared psychosocial phenotypes in a female Interstitial Cystitis/painful bladder syndrome cohort and an age matched cohort without that diagnosis.Materials and Methods: Female patients with Interstitial Cystitis/painful bladder syndrome and controls without the condition completed a psychosocial phenotyping questionnaire battery, including a demographics/history form and validated questionnaires focused on a range of presenting symptoms, psychosocial parameters and quality of life. Specific measures included Interstitial Cystitis symptom and problem index, McGill Pain Questionnaire, Medical Outcomes Study Sleep Scale, Center for Epidemiological Studies Depression Scale, State-Trait Anxiety Inventory, Pain Catastrophizing Scale, Female Sexual Functioning Index and Multidimensional Scale of Perceived Social Support and Medical Outcomes Study Short Form-12 quality of life. Direct comparisons and correlations were made to establish group differences and the strength of associat...
Sandra H Berry - One of the best experts on this subject based on the ideXlab platform.
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the prevalence and overlap of Interstitial Cystitis bladder pain syndrome and chronic prostatitis chronic pelvic pain syndrome in men results of the rand Interstitial Cystitis epidemiology male study
The Journal of Urology, 2013Co-Authors: Anne M Suskind, Marika J Suttorp, Marc N Elliott, Sandra H Berry, Brett Ewing, Quentin J ClemensAbstract:Purpose: As part of the RICE (RAND Interstitial Cystitis Epidemiology) study, we developed validated case definitions to identify Interstitial Cystitis/bladder pain syndrome in women and chronic prostatitis/chronic pelvic pain syndrome in men. Using population based screening methods, we applied these case definitions to determine the prevalence of these conditions in men.Materials and Methods: A total of 6,072 households were contacted by telephone to screen for men who had symptoms of Interstitial Cystitis/bladder pain syndrome or chronic prostatitis/chronic pelvic pain syndrome. An initial 296 men screened positive, of whom 149 met the inclusionary criteria and completed the telephone interview. For Interstitial Cystitis/bladder pain syndrome 2 case definitions were applied (1 with high sensitivity and 1 with high specificity), while for chronic prostatitis/chronic pelvic pain syndrome a single case definition (with high sensitivity and specificity) was used. These case definitions were used to classif...
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comparison of an Interstitial Cystitis bladder pain syndrome clinical cohort with symptomatic community women from the rand Interstitial Cystitis epidemiology study
The Journal of Urology, 2012Co-Authors: Katy S Konkle, Marika J Suttorp, Marc N Elliott, Sandra H Berry, Daniel J Clauw, Lara Hilton, Quentin J ClemensAbstract:Purpose: The RAND Interstitial Cystitis Epidemiology survey estimated that 2.7% to 6.5% of United States women have urinary symptoms consistent with a diagnosis of Interstitial Cystitis/bladder pain syndrome. We describe the demographic and clinical characteristics of the symptomatic community based RAND Interstitial Cystitis Epidemiology cohort, and compare them with those of a clinically based Interstitial Cystitis/bladder pain syndrome cohort.Materials and Methods: Subjects included 3,397 community women who met the criteria for the RAND Interstitial Cystitis Epidemiology high sensitivity case definition, and 277 women with an Interstitial Cystitis/bladder pain syndrome diagnosis recruited from specialist practices across the United States (clinical cohort). Questions focused on demographic information, symptom severity, quality of life indicators, concomitant diagnoses and treatment.Results: Average symptom duration for both groups was approximately 14 years. Women in the clinical cohort reported wors...
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prevalence of symptoms of bladder pain syndrome Interstitial Cystitis among adult females in the united states
The Journal of Urology, 2011Co-Authors: Sandra H Berry, Quentin J Clemens, Laura M Bogart, Marika J Suttorp, Marc N Elliott, Leroy M Nyberg, Michael A Stoto, Paul W EggersAbstract:Purpose: Bladder pain syndrome/Interstitial Cystitis is a poorly understood condition that can cause serious disability. We provide the first population based symptom prevalence estimate to our knowledge among United States adult females.Materials and Methods: We developed and validated 2 case definitions to identify bladder pain syndrome/Interstitial Cystitis symptoms. Beginning in August 2007 we telephoned United States households, seeking adult women with bladder symptoms or a bladder pain syndrome/Interstitial Cystitis diagnosis. Second stage screening identified those subjects who met case definition criteria. Each completed a 60-minute interview on the severity and impact of bladder symptoms, health care seeking and demographics. Data collection ended in April 2009. Using population and nonresponse weights we calculated prevalence estimates based on definitions spanning a range of sensitivity and specificity. We used United States Census counts to estimate the number of affected women in 2006. The r...
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prevalence and correlates of sexual dysfunction among women with bladder pain syndrome Interstitial Cystitis
Urology, 2011Co-Authors: Laura M Bogart, Quentin J Clemens, Marika J Suttorp, Marc N Elliott, Sandra H BerryAbstract:Objectives To examine the prevalence and correlates of general and bladder pain syndrome/Interstitial Cystitis (BPS/IC)-specific sexual dysfunction among women in the RAND Interstitial Cystitis Epidemiology study using a probability sample survey of U.S. households. Sexual dysfunction can contribute to a reduced quality of life for women with bladder pain syndrome/Interstitial Cystitis (BPS/IC). Methods We telephoned 146 231 households to identify women who reported bladder symptoms or a BPS/IC diagnosis. Those who reported either underwent a second-stage screening using the RAND Interstitial Cystitis Epidemiology study high-specificity symptom criteria. The criteria were pain, pressure, or discomfort in pelvic area; daytime urinary frequency ≥10 times or urgency due to pain, pressure, or discomfort (not fear of wetting); pain that worsened as the bladder filled; bladder symptoms did not resolve after antibiotic treatment; and patients never treated with hormone injections for endometriosis. Women who met the RAND Interstitial Cystitis Epidemiology criteria (n = 1469) completed measures of BPS/IC-specific and general sexual dysfunction symptoms, bladder symptom severity, general physical health, depression, medical care-seeking, and sociodemographic characteristics. Results Of those with a current sexual partner (75%), 88% reported ≥1 general sexual dysfunction symptom and 90% reported ≥1 BPS/IC-specific sexual dysfunction symptom in the past 4 weeks. In the multivariate models, BPS/IC-specific sexual dysfunction was significantly associated with more severe BPS/IC symptoms, younger age, worse depression symptoms, and worse perceived general health. Multivariate correlates of general sexual dysfunction included non-Latino race/ethnicity, being married, and having depression symptoms. Conclusions The results of our study have shown that women with BPS/IC symptoms experience very high levels of sexual dysfunction. Also, sexual dysfunction covaries with symptoms.
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development validation and testing of an epidemiological case definition of Interstitial Cystitis painful bladder syndrome
The Journal of Urology, 2010Co-Authors: Sandra H Berry, Laura M Bogart, Chau Pham, Karin Liu, Leroy M Nyberg, Michael A Stoto, Marika Suttorp, Quentin J ClemensAbstract:Purpose: No standard case definition exists for Interstitial Cystitis/painful bladder syndrome for patient screening or epidemiological studies. As part of the RAND Interstitial Cystitis Epidemiology study, we developed a case definition for Interstitial Cystitis/painful bladder syndrome with known sensitivity and specificity. We compared this definition with others used in Interstitial Cystitis/painful bladder syndrome epidemiological studies.Materials and Methods: We reviewed the literature and performed a structured, expert panel process to arrive at an Interstitial Cystitis/painful bladder syndrome case definition. We developed a questionnaire to assess Interstitial Cystitis/painful bladder syndrome symptoms using this case definition and others used in the literature. We administered the questionnaire to 599 women with Interstitial Cystitis/painful bladder syndrome, overactive bladder, endometriosis or vulvodynia. The sensitivity and specificity of each definition was calculated using physician assig...
