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Sharon C. Kerwin - One of the best experts on this subject based on the ideXlab platform.
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canine thoracolumbar invertebral Disk Disease pathophysiology neurologic examination and emergency medical therapy
Compendium (Yardley PA), 2009Co-Authors: Jonathan M. Levine, Sharon C. KerwinAbstract:Thoracolumbar Intervertebral Disk Disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal incontinence in dogs. Research offers insights into the pathophysiology, diagnosis, prognosis, and treatment of this disorder. The comparative efficacy of many familiar therapies remains unknown and controversial. This article reviews the pathophysiology and epidemiology of this condition and the examination and emergency medical therapy of dogs with suspected thoracolumbar IVDD.
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Canine Thoracolumbar Intervertebral Disk Disease: Diagnosis, Prognosis,
2009Co-Authors: John F. Griffin, Sharon C. Kerwin, Jonathan M. Levine, Robert C. ColeAbstract:Thoracolumbar Intervertebral Disk Disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal in- continence in dogs. A companion article reviewed pathophysiology, epidemiology, physical ex- amination, and emergency medical therapy. This article addresses the diagnosis, prognosis, and treatment of dogs with thoracolumbar IVDD.
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canine thoracolumbar Intervertebral Disk Disease pathophysiology neurologic examination and
2009Co-Authors: John F. Griffin, Jonathan M. Levine, Sharon C. KerwinAbstract:Thoracolumbar Intervertebral Disk Disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal incon- tinence in dogs. Research offers insights into the pathophysiology, diagnosis, prognosis, and treatment of this disorder. The comparative efficacy of many familiar therapies remains unknown and controversial. This article reviews the pathophysiology and epidemiology of this condition and the examination and emergency medical therapy of dogs with suspected thoracolumbar IVDD. A companion article addresses diagnosis, prognosis, and treatment.
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treatment of thoracolumbar spinal cord compression associated with histoplasma capsulatum infection in a cat
Javma-journal of The American Veterinary Medical Association, 2007Co-Authors: Arathi Vinayak, Sharon C. Kerwin, R R PoolAbstract:Case Description—A 7-year-old domestic shorthair cat with a 2-month history of decreased appetite and weight loss was examined because of paraparesis of 1 week's duration that had progressed to paraplegia 3 days earlier. Clinical Findings—Neurologic examination revealed normo- to hyperreflexia and absence of deep pain sensation in the hind limbs and thoracolumbar spinal hyperesthesia. Neuro-anatomically, the lesion was located within the T3 through L3 spinal cord segments. Biochemical analysis and cytologic examination of CSF revealed no abnormalities. Radiography revealed narrowing of the T11-12 Intervertebral Disk space and Intervertebral foramen suggestive of Intervertebral Disk Disease. Myelography revealed an extradural mass centered at the T12-13 Intervertebral Disk space with extension over the dorsal surfaces of T11-13 and L1 vertebral bodies. Treatment and Outcome—A right-sided hemilaminectomy was performed over the T11-12, T12-13, and T13-L1 Intervertebral Disk spaces, and a space-occupying mass...
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concentrations of 15f2t isoprostane in urine of dogs with Intervertebral Disk Disease
American Journal of Veterinary Research, 2006Co-Authors: Maureen Mcmichael, Sharon C. Kerwin, Giselle Hosgood, Craig G Ruaux, Wendy I Baltzer, Jorg M Steiner, David A WilliamsAbstract:Objective—To measure 15F2t isoprostane concentrations in the urine of dogs undergoing ovariohysterectomy (OHE) and dogs undergoing surgery because of Intervertebral Disk Disease (IVDD) and to assess relationships between urinary concentrations of 15F2t isoprostanes and neurologic score in dogs with IVDD. Animals—11 dogs undergoing OHE and 32 dogs with IVDD undergoing hemilaminectomy. Procedures—Paired urine samples were obtained at induction of anesthesia and approximately 1 hour after OHE (controls) and were collected from dogs with IVDD at induction of anesthesia (28 samples) and approximately 1 hour after hemilaminectomy (31 samples); 26 paired urine samples were obtained from dogs with IVDD. Urinary isoprostane concentrations were measured by use of a commercial ELISA, and results were adjusted on the basis of urinary creatinine concentrations. Differences in the mean isoprostane-to-creatinine ratio were analyzed. Neurologic score was determined in dogs with IVDD by use of the modified Frankel scoring...
Robert L Swezey - One of the best experts on this subject based on the ideXlab platform.
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pathophysiology and treatment of Intervertebral Disk Disease
Rheumatic Diseases Clinics of North America, 1993Co-Authors: Robert L SwezeyAbstract:Back pain is like quality--you know it when you see it--but it is hard to precisely identify and quantify all the factors that are responsible for it. Quality of care in back pain compounds this dilemma. Because we cannot often precisely identify specific causes of back pain (we are usually overwhelmed by an excess of putative factors) and we cannot often assess therapeutic results with precision (double-blind randomized studies of multivaried pathologic and psychologic factors and multiple coexistent therapies and compliance variables), assessment of treatment modes is extremely difficult. Nonetheless, we ultimately must treat the patient. Nihilism is unrealistic. The art and science of medicine must be integrated. Pseudoscience based on high-tech dazzle must be viewed with appropriate skepticism. Treatments must enlist patients' understanding of their options with carefully directed self-care and home therapies augmented when needed by proven safe treatments as well as reasonable, inexpensive, safe remedies still lacking proof of efficacy to help comfort and support the patient during the healing process. Surgical interventions, with a few exceptions, are a last resort and should be employed judiciously and skillfully by experienced surgeons. The surgeon also must be both knowledgeable and experienced in the conservative treatment of low back pain to know when conservative treatment has truly failed. Failure to profit from an investment in a poorly managed business does not mean that the business per se has no value but rather that the business can only prosper with committed qualified management. No less can be asked of conservative rehabilitative therapies before they have been judged a bankrupt failure. Conservative treatment of low back pain is not complicated, but it does require knowledge, skill, and persistence and the ability to recognize when its failure is the result of a lack of response to optimal therapy and when further therapy is procrastination, redundant, and wasteful of time, suffering, and resources.
Ayne Murata Hayashi - One of the best experts on this subject based on the ideXlab platform.
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s100β levels in csf of nonambulatory dogs with Intervertebral Disk Disease treated with electroacupuncture
Journal of veterinary medicine, 2013Co-Authors: Ayne Murata Hayashi, Ana Carolina Brandao De Campos Fonseca Pinto, Silvia Renata Gaido Cortopassi, Valdecir Marvulle, Jessica Ruivo Maximino, Gerson Chadi, Julia Maria MateraAbstract:The aim of the study was to investigate S100β levels in the cerebrospinal fluid of nonambulatory dogs with Intervertebral Disk Disease treated with electroacupuncture: 10 dogs with thoracolumbar Disk extrusion graded 3 to 5 (EA group) and 7 dogs without neurologic dysfunction (control group). All dogs regained ambulation. S100β was detected by Western blot analysis where EA group dogs were evaluated at two time points (M1 = before EA and M2 = when the dogs return ambulation) and at one time point from control group. In EA group dogs M1-S100β levels were significantly higher than in control group. EA group dogs were divided into subgroups A (n = 7-early motor recovery; 6.7 ± 7.8 days) and B (n = 3-late motor recovery; 76 ± 17.0 days). M1-S100β levels were similar between subgroups A and B. However, M2-S100β levels were significantly higher in subgroup B than in subgroup A. An elevated S100β levels were observed in dogs with late motor recovery. S100β may be associated with neuroplasticity following spinal cord injuries with Intervertebral Disk extrusion. Further studies with larger numbers of subjects and control group with affected dogs are necessary to investigate the relationship between neurotrophic factors and electroacupuncture stimulation.
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evaluation of electroacupuncture treatment for thoracolumbar Intervertebral Disk Disease in dogs
Javma-journal of The American Veterinary Medical Association, 2007Co-Authors: Ayne Murata Hayashi, Julia Maria Matera, Ana Carolina Brandao De Campos Fonseca PintoAbstract:Objective—To evaluate use of electroacupuncture combined with standard Western medical treatment versus Western medical treatment alone for treatment of thoracolumbar Intervertebral Disk Disease in dogs. Design—Prospective controlled study. Animals—50 dogs with signs of thoracolumbar Intervertebral Disk Disease. Procedures—Dogs were randomly allocated to 1 of 2 treatment groups and classified as having grade 1 to 5 neurologic dysfunction. Dogs in group 1 received electroacupuncture stimulation combined with standard Western medical treatment; those in group 2 received only standard Western medical treatment. A numeric score for neurologic function was evaluated at 4 time points to evaluate effects of treatments. Results—Time (mean ± SD) to recover ambulation in dogs with grade 3 and 4 dysfunction in group 1 (10.10 ± 6.49 days) was significantly lower than in group 2 (20.83 ± 11.99 days). Success (able to walk without assistance) rate for dogs with grade 3 and 4 dysfunction in group 1 (10/10 dogs) was sign...
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electro acupuncture and chinese herbs for treatment of cervical Intervertebral Disk Disease in a dog
Journal of Veterinary Science, 2007Co-Authors: Ayne Murata Hayashi, Julia Maria Matera, Ana Carolina Brandao De Campos Fonseca Pinto, Tatiana Soares Da Silva, Silvia Renata Gaido CortopassiAbstract:A non-ambulatory dog with tetraparesis following a pain episode that had evolved over 2 months was submitted for medical treatment and diagnosed with Intervertebral Disk Disease at C3-C4 and dorsal extradural compression at C1-C2 and C3-C4 using myelography and computed tomography. The dog experienced ambulation recovery after 15 days of treatment with only electroacupuncture and Chinese herbal medicine, with marked improvement occurring after only 10 treatments. Six months of followup demonstrated that the dog was stable and had no recurrence of symptoms. Therefore, it was concluded that the combination of electroacupuncture and Chinese herbal medicine was responsible for motor rehabilitation.
Ana Carolina Brandao De Campos Fonseca Pinto - One of the best experts on this subject based on the ideXlab platform.
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s100β levels in csf of nonambulatory dogs with Intervertebral Disk Disease treated with electroacupuncture
Journal of veterinary medicine, 2013Co-Authors: Ayne Murata Hayashi, Ana Carolina Brandao De Campos Fonseca Pinto, Silvia Renata Gaido Cortopassi, Valdecir Marvulle, Jessica Ruivo Maximino, Gerson Chadi, Julia Maria MateraAbstract:The aim of the study was to investigate S100β levels in the cerebrospinal fluid of nonambulatory dogs with Intervertebral Disk Disease treated with electroacupuncture: 10 dogs with thoracolumbar Disk extrusion graded 3 to 5 (EA group) and 7 dogs without neurologic dysfunction (control group). All dogs regained ambulation. S100β was detected by Western blot analysis where EA group dogs were evaluated at two time points (M1 = before EA and M2 = when the dogs return ambulation) and at one time point from control group. In EA group dogs M1-S100β levels were significantly higher than in control group. EA group dogs were divided into subgroups A (n = 7-early motor recovery; 6.7 ± 7.8 days) and B (n = 3-late motor recovery; 76 ± 17.0 days). M1-S100β levels were similar between subgroups A and B. However, M2-S100β levels were significantly higher in subgroup B than in subgroup A. An elevated S100β levels were observed in dogs with late motor recovery. S100β may be associated with neuroplasticity following spinal cord injuries with Intervertebral Disk extrusion. Further studies with larger numbers of subjects and control group with affected dogs are necessary to investigate the relationship between neurotrophic factors and electroacupuncture stimulation.
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evaluation of electroacupuncture treatment for thoracolumbar Intervertebral Disk Disease in dogs
Javma-journal of The American Veterinary Medical Association, 2007Co-Authors: Ayne Murata Hayashi, Julia Maria Matera, Ana Carolina Brandao De Campos Fonseca PintoAbstract:Objective—To evaluate use of electroacupuncture combined with standard Western medical treatment versus Western medical treatment alone for treatment of thoracolumbar Intervertebral Disk Disease in dogs. Design—Prospective controlled study. Animals—50 dogs with signs of thoracolumbar Intervertebral Disk Disease. Procedures—Dogs were randomly allocated to 1 of 2 treatment groups and classified as having grade 1 to 5 neurologic dysfunction. Dogs in group 1 received electroacupuncture stimulation combined with standard Western medical treatment; those in group 2 received only standard Western medical treatment. A numeric score for neurologic function was evaluated at 4 time points to evaluate effects of treatments. Results—Time (mean ± SD) to recover ambulation in dogs with grade 3 and 4 dysfunction in group 1 (10.10 ± 6.49 days) was significantly lower than in group 2 (20.83 ± 11.99 days). Success (able to walk without assistance) rate for dogs with grade 3 and 4 dysfunction in group 1 (10/10 dogs) was sign...
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electro acupuncture and chinese herbs for treatment of cervical Intervertebral Disk Disease in a dog
Journal of Veterinary Science, 2007Co-Authors: Ayne Murata Hayashi, Julia Maria Matera, Ana Carolina Brandao De Campos Fonseca Pinto, Tatiana Soares Da Silva, Silvia Renata Gaido CortopassiAbstract:A non-ambulatory dog with tetraparesis following a pain episode that had evolved over 2 months was submitted for medical treatment and diagnosed with Intervertebral Disk Disease at C3-C4 and dorsal extradural compression at C1-C2 and C3-C4 using myelography and computed tomography. The dog experienced ambulation recovery after 15 days of treatment with only electroacupuncture and Chinese herbal medicine, with marked improvement occurring after only 10 treatments. Six months of followup demonstrated that the dog was stable and had no recurrence of symptoms. Therefore, it was concluded that the combination of electroacupuncture and Chinese herbal medicine was responsible for motor rehabilitation.
Jonathan M. Levine - One of the best experts on this subject based on the ideXlab platform.
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canine thoracolumbar invertebral Disk Disease pathophysiology neurologic examination and emergency medical therapy
Compendium (Yardley PA), 2009Co-Authors: Jonathan M. Levine, Sharon C. KerwinAbstract:Thoracolumbar Intervertebral Disk Disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal incontinence in dogs. Research offers insights into the pathophysiology, diagnosis, prognosis, and treatment of this disorder. The comparative efficacy of many familiar therapies remains unknown and controversial. This article reviews the pathophysiology and epidemiology of this condition and the examination and emergency medical therapy of dogs with suspected thoracolumbar IVDD.
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Canine Thoracolumbar Intervertebral Disk Disease: Diagnosis, Prognosis,
2009Co-Authors: John F. Griffin, Sharon C. Kerwin, Jonathan M. Levine, Robert C. ColeAbstract:Thoracolumbar Intervertebral Disk Disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal in- continence in dogs. A companion article reviewed pathophysiology, epidemiology, physical ex- amination, and emergency medical therapy. This article addresses the diagnosis, prognosis, and treatment of dogs with thoracolumbar IVDD.
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canine thoracolumbar Intervertebral Disk Disease pathophysiology neurologic examination and
2009Co-Authors: John F. Griffin, Jonathan M. Levine, Sharon C. KerwinAbstract:Thoracolumbar Intervertebral Disk Disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal incon- tinence in dogs. Research offers insights into the pathophysiology, diagnosis, prognosis, and treatment of this disorder. The comparative efficacy of many familiar therapies remains unknown and controversial. This article reviews the pathophysiology and epidemiology of this condition and the examination and emergency medical therapy of dogs with suspected thoracolumbar IVDD. A companion article addresses diagnosis, prognosis, and treatment.
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matrix metalloproteinase 9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from Intervertebral Disk Disease
American Journal of Veterinary Research, 2006Co-Authors: Jonathan M. Levine, Joan R. Coates, Robert L Bergman, Craig G Ruaux, Jorg M Steiner, David A WilliamsAbstract:Objective—To detect matrix metalloproteinase (MMP)-9 in serum and CSF and determine relationships between MMP activity and severity of Disease, duration of clinical signs, and duration of hospitalization in dogs with acute Intervertebral Disk Disease (IVDD). Animals—35 dogs with acute IVDD and 8 clinically normal control dogs. Procedure—CSF and serum were collected from affected and control dogs. Zymography was used to detect MMP-9. Results—Activity of MMP-9 in CSF was detected in 6 of 35 dogs with IVDD; activity was significantly more common in dogs with duration of signs < 24 hours. Paraplegic dogs were more likely to have MMP-9 activity in the CSF than non-paraplegic dogs. No significant difference in hospitalization time was detected in dogs with IVDD between those with and without activity of MMP-9 in the CSF. Serum MMP-9 was detected more frequently in dogs with IVDD than in control dogs. Conclusions and Clinical Relevance—Data were consistent with results of experimental rodent spinal cord injury s...
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evaluation of the association between spondylosis deformans and clinical signs of Intervertebral Disk Disease in dogs 172 cases 1999 2000
Javma-journal of The American Veterinary Medical Association, 2006Co-Authors: Gwendolyn J Levine, Jonathan M. Levine, Michael Walker, R R Pool, Geoffrey T FosgateAbstract:Objective—To evaluate the association between spondylosis deformans and clinical signs of Intervertebral Disk Disease (IVDD) in dogs. Design—Retrospective case series. Animals—210 dogs. Procedure—Records of 172 dogs with clinical signs of IVDD and 38 dogs with other neurologic disorders were reviewed. Signalment, sites of spondylosis, severity of associated osteophytosis, type of Disk herniation, and duration of signs were recorded. Results—Dogs with IVDD had significantly fewer sites of involvement and lower grades of spondylosis deformans, compared with those in the non-IVDD group. When groups were adjusted for age and weight via multivariate linear regression, there were no differences in severity of osteophytosis or number of affected sites. Dogs with type II Disk Disease had higher numbers of affected sites and more severe changes, compared with dogs with type I Disk herniation. There was no difference between groups in the rate at which IVDD was diagnosed at sites of spondylosis, compared with the r...
