Linalyl Acetate

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Geun Hee Seol - One of the best experts on this subject based on the ideXlab platform.

  • Linalyl Acetate as a potential preventive agent against muscle wasting in rheumatoid arthritis rats chronically exposed to nicotine
    Journal of Pharmacological Sciences, 2021
    Co-Authors: Eunhye Seo, Yu Shan Hsieh, You Kyoung Shin, Jeong Min Lee, Geun Hee Seol
    Abstract:

    ABSTRACT Cigarette smoking has detrimental effects on rheumatoid arthritis (RA), characterized by muscle wasting. Linalyl Acetate (LA), the main component of Lavandula angustifolia Mill. (lavender) oil, has anti-inflammatory properties. We investigated the detrimental effects of chronic nicotine exposure in rats with RA, as well as the abilities of lavender oil and LA to prevent muscle wasting. Rats with RA induced by type II collagen were exposed to nicotine for 22 days from day 1. Lavender oil or LA was administered twice a week during the experiment. Compared with control, collagen-induced arthritis (CIA) and chronic nicotine exposure plus CIA (NicoCIA) showed increases in hind paw thickness and serum interleukin (IL)-6 and decreases in body weight and serum insulin-like growth factor (IGF)-1 levels. Moreover, weight and fiber cross-sectional area of the gastrocnemius muscle were much lower, and mitochondrial membrane potential of the gastrocnemius muscle was higher, in the NicoCIA than in the CIA. These alterations in the NicoCIA were prevented by lavender oil and LA. Importantly, LA showed greater activity than lavender oil in preventing IGF-1 reduction in the NicoCIA. These findings suggest that lavender oil and LA may have preventive benefit in RA by counteracting muscle wasting associated with chronic nicotine exposure.

  • protection of the neurovascular unit from calcium related ischemic injury by Linalyl Acetate
    Chinese Journal of Physiology, 2021
    Co-Authors: Yu Shan Hsieh, You Kyoung Shin, Geun Hee Seol
    Abstract:

    Calcium-related ischemic injury (CRII) can damage cells of the neurovascular unit (NVU). Here, we investigate the protective effects of Linalyl Acetate (LA) against CRII-induced NVU damage and evaluate the underlying mechanisms. The protective effects of LA in cell lines representative of NVU components (BEND, SH-SY5Y, BV2, and U373 cells) were evaluated following exposure to oxygen-glucose deprivation/reoxygenation alone (OGD/R-only) or OGD/R in the presence of 5 mM extracellular calcium ([Ca2+]o) to mimic CRII. LA reversed damage under OGD/R-only conditions by blocking p47phox/NADPH oxidase (NOX) 2 expression, reactive oxygen species (ROS) production, nitric oxide (NO) abnormality, and lactate dehydrogenase (LDH) release only in the BEND cells. However, under CRII-mimicking conditions, LA reversed NO abnormality and matrix metalloproteinase (MMP)-9 activation in the BEND murine brain endothelial cells; inhibited p47phox expression in the human SH-SY5Y neural-like cells; decreased NOX2 expression and ROS generation in the BV2 murine microglial cells; and reduced p47phox expression in the U373 human astrocyte-like cells. Importantly, LA protected against impairment of the neural cells, astrocytes, and microglia, all of which are cellular components of the NVU induced by exposure to CRII-mimicking conditions, by reducing LDH release. We found that LA exerted a protective effect in the BEND cells that may differ from its protective effects in other NVU cell types, following OGD/R-induced damage in the context of elevated [Ca2+]o.

  • sex specific susceptibility to type 2 diabetes mellitus and preventive effect of Linalyl Acetate
    Life Sciences, 2020
    Co-Authors: You Kyoung Shin, Yu Shan Hsieh, Soonho Kwon, Purum Kang, Young A Han, Geun Hee Seol
    Abstract:

    Abstract Aims Biological, psychosocial and lifestyle risk factors interact in the development of type 2 diabetes mellitus (T2DM). To date, the effects of sex, chronic stress (CS) and high-fat diet (HFD) on T2DM and the ability of Linalyl Acetate (LA) to prevent T2DM have not been determined. This study therefore explored the differential effects of CS and HFD on T2DM, as well as the ability of LA to prevent T2DM development, in male and female rats. Main methods T2DM was induced in rats by feeding an HFD and placing them under immobilization stress for 2 h/day for 3 weeks. Low-dose streptozotocin was administered on day 15, and LA was administered for 3 weeks. Key findings Fasting blood sugar (FBS) increased in HFD-fed male, but not female, rats. CS further increased FBS in HFD-fed rats, whereas CS alone did not alter FBS. The homeostatic model assessment-insulin resistance (HOMA-IR) showed results similar to FBS. Serum corticosterone levels markedly increased only in HFD-fed male rats exposed to CS. Pancreas nuclear factor kappa B (NF-κB) levels were higher in HFD-fed male rats exposed to CS than in control rats although there were no sex differences. LA 10 mg/kg significantly reduced FBS, serum insulin, HOMA-IR, and serum corticosterone levels in HFD-fed male rats exposed to CS. LA 10 mg/kg also tended to reduce NF-κB in the pancreas and significantly increased mitochondrial membrane potential (MMP) in the liver. Significance Male rats are vulnerable to T2DM induced by CS and HFD, and LA can prevent T2DM in these rats not only by reducing insulin resistance and corticosterone levels but by increasing MMP in the liver.

  • Linalyl Acetate prevents three related factors of vascular damage in copd like and hypertensive rats
    Life Sciences, 2019
    Co-Authors: Yu Shan Hsieh, Soonho Kwon, You Kyoung Shin, Young A Han, Geun Hee Seol
    Abstract:

    Preventing vascular damage is considered an effective strategy in patients who suffer from chronic obstructive pulmonary disease (COPD) with hypertension. Here, we investigated vascular damage in COPD-like and hypertensive rats, which demonstrated the presence of the three related factors of COPD with hypertension. These include elevated systolic blood pressure (SBP), serum malondialdehyde (MDA) and serum lactate dehydrogenase (LDH), which are positively correlated with vascular damage in patients. In addition to increases in these three related factors, COPD-like and hypertensive rats exhibited increased levels of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-6, and matrix metallopeptidase-9 in bronchoalveolar lavage fluid, and enlargement of alveolar airspaces, recapitulating clinical findings in previous studies of patients. Moreover, the appearance of these related factors was prevented by Linalyl Acetate. Our results provide novel insight into the potential of LA to prevent vascular damage and elevated SBP, serum MDA and serum LDH in COPD with hypertension, and could lead to an alternative strategy for preventing vascular damage for patients who suffered from COPD with hypertension in a clinical setting.

  • Linalyl Acetate prevents hypertension related ischemic injury
    PLOS ONE, 2018
    Co-Authors: Yu Shan Hsieh, Soonho Kwon, Hui Su Lee, Geun Hee Seol
    Abstract:

    Ischemic stroke remains an important cause of disability and mortality. Hypertension is a critical risk factor for the development of ischemic stroke. Control of risk factors, including hypertension, is therefore important for the prevention of ischemic stroke. Linalyl Acetate (LA) has been reported to have therapeutic effects in ischemic stroke by modulating intracellular Ca2+ concentration and having anti-oxidative properties. The preventive efficacy of LA has not yet been determined. This study therefore investigated the preventive efficacy of LA in rat aortas exposed to hypertension related-ischemic injury, and the mechanism of action of LA.Hypertension was induced in vivo following ischemic injury to the aorta induced by oxygen-glucose deprivation and reoxygenation in vitro. Effects of LA were assayed by western blotting, by determining concentrations of lactate dehydrogenase (LDH) and reactive oxygen species (ROS) and by vascular contractility assays. LA significantly reduced systolic blood pressure in vivo. In vitro, LA suppressed ischemic injury-induced expression of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p47phox, as well as ROS production, LDH release, and ROS-induced endothelial nitric oxide synthase suppression. These findings indicate that LA has anti-hypertensive properties that can prevent hypertension-related ischemic injury and can prevent NADPH oxidase-induced production of ROS.

Gabriela Mazzanti - One of the best experts on this subject based on the ideXlab platform.

  • letter to the editor regarding rifm fragrance ingredient safety assessment Linalyl Acetate cas registry number 115 95 7 by api et al 2015
    Food and Chemical Toxicology, 2016
    Co-Authors: Antonella Di Sotto, Gabriela Mazzanti
    Abstract:

    Present letter is aimed at clarifying some critical points highlighted by Api et al. as major limits for the reliability of our data on the genotoxicity of Linalyl Acetate. Particularly, we explained the choice of the study design and methodology applied for carrying out the Ames test and the micronucleus assay.

  • genotoxicity of lavender oil Linalyl Acetate and linalool on human lymphocytes in vitro
    Environmental and Molecular Mutagenesis, 2011
    Co-Authors: Antonella Di Sotto, Fabio Carbone, Patrizia Hrelia, Gabriela Mazzanti, Francesca Maffei
    Abstract:

    The potential genotoxicity of lavender essential oil and its major components, linalool, and Linalyl Acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non-toxic concentrations (0.5–100 μg/ml), Linalyl Acetate increased the frequency of micronuclei significantly and in concentration-dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of lavender oil can be related to the presence of Linalyl Acetate, which seems to have a profile of an aneugenic agent. Environ. Mol. Mutagen. 52:69–71, 2011. © 2010 Wiley-Liss, Inc.

  • genotoxicity of lavender oil Linalyl Acetate and linalool on human lymphocytes in vitro
    Environmental and Molecular Mutagenesis, 2011
    Co-Authors: Antonella Di Sotto, Fabio Carbone, Patrizia Hrelia, Gabriela Mazzanti, Francesca Maffei
    Abstract:

    The potential genotoxicity of lavender essential oil and its major components, linalool, and Linalyl Acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non-toxic concentrations (0.5-100 μg/ml), Linalyl Acetate increased the frequency of micronuclei significantly and in concentration-dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of lavender oil can be related to the presence of Linalyl Acetate, which seems to have a profile of an aneugenic agent.

  • antifungal activity of lavandula angustifolia essential oil against candida albicans yeast and mycelial form
    Medical Mycology, 2005
    Co-Authors: F D Dauria, Giuseppe Salvatore, M Tecca, V Strippoli, Lucia Battinelli, Gabriela Mazzanti
    Abstract:

    The antifungal activity of the essential oil of Lavandula angustifolia Mill. (lavender oil) and its main components, linalool and Linalyl Acetate, was investigated against 50 clinical isolates of Candida albicans (28 oropharyngeal strains, 22 vaginal strains) and C. albicans ATCC 3153. Growth inhibition, killing time and inhibition of germ tube formation were evaluated. The chemical composition of the essential oil was determined by gas chromatography and mass spectrometry. Lavender oil inhibited C. albicans growth: mean minimum inhibitory concentration (MIC) of 0.69% (vol./vol.) (vaginal strains) and 1.04% (oropharyngeal strains); mean MFC of 1.1% (vaginal strains) and 1.8% (oropharyngeal strains). Linalool was more effective than essential oil: mean MIC of 0.09% (vaginal strains) and 0.29% (oropharyngeal strains); mean MFC of 0.1% (vaginal strains) and 0.3% (oropharyngeal strains). Linalyl Acetate was almost ineffective. Lavender oil (2%) killed 100% of the C. albicans ATCC 3153 cells within 15 min; linalool (0.5%) killed 100% of the cells within 30 s. The essential oil inhibited germ tube formation (mean MIC of 0.09%), as did the main components (MIC of 0.11% for linalool and 0.08% for Linalyl Acetate). Both the essential oil and its main components inhibited hyphal elongation of C. albicans ATCC 3153 (about 50% inhibition at 0.016% with each substance). Lavender oil shows both fungistatic and fungicidal activity against C. albicans strains. At lower concentrations, it inhibits germ tube formation and hyphal elongation, indicating that it is effective against C. albicans dimorphism and may thus reduce fungal progression and the spread of infection in host tissues.

  • local anaesthetic activity of the essential oil of lavandula angustifolia
    Planta Medica, 1999
    Co-Authors: Carla Ghelardini, Nicoletta Galeotti, Giuseppe Salvatore, Gabriela Mazzanti
    Abstract:

    In this work we studied the local anaesthetic activity of the essential oil obtained from Lavandula angustifolia Mill., a medicinal plant traditionally used as an antispasmodic. We compared its activity to the essential oils obtained from two citrus fruits, Citrus reticulata Blanco and Citrus limon (L.) Burm. f., which have no medical uses. Biological tests were also performed on the major pure components of L. angustifolia Mill. essential oil: linalol and Linalyl Acetate as determined by GC and confirmed by GC-MS. Anaesthetic activity was evaluated in vivo in the rabbit conjunctival reflex test, and in vitro in a rat phrenic nerve-hemidiaphragm preparation. The essential oil of L. angustifolia, Linalyl Acetate and linanol (0.01-10 micrograms/ml) but not the oils of Citrus reticulata and Citrus limon were able to drastically reduce, in a dose-dependent manner, the electrically evoked contractions of rat phrenic-hemidiaphragm. In the rabbit conjunctival reflex test treatment with a solution of essential oil of L. angustifolia, as well as Linalyl Acetate and linalol (30-2500 micrograms/ml administered in the conjunctival sac) allow a dose-dependent increase in the number of stimuli necessary to provoke the reflex, thus confirming in vivo the local anaesthetic activity observed in vitro.

Anne Marie Api - One of the best experts on this subject based on the ideXlab platform.

Mohan V. Jacob - One of the best experts on this subject based on the ideXlab platform.

  • study of carrier blocking property of poly Linalyl Acetate thin layer by electric field induced optical second harmonic generation measurement
    Chemical Physics Letters, 2014
    Co-Authors: Dai Taguchi, Liam J. Anderson, Takaaki Manaka, Mitsumasa Iwamoto, Mohan V. Jacob
    Abstract:

    By using electric-field-induced optical second-harmonic generation (EFISHG) measurement, we studied the carrier-blocking property of poly-Linalyl Acetate (PLA) thin layers sandwiched in indium-zinc-oxide (IZO)/PLA/C60/Al double-layer diodes. Results showed that the PLA layer totally blocks electrons crossing the C60 layer, and also blocks holes entering from the IZO layer. The EFISHG measurement effectively substantiates the hole-blocking electron-blocking property of the PLA layer sandwiched in double layer diodes.

  • Compatibility of plasma-deposited Linalyl Acetate thin films with organic electronic device fabrication techniques
    Journal of Materials Science, 2013
    Co-Authors: Liam J. Anderson, Christopher D. Easton, Mohan V. Jacob
    Abstract:

    Contact angle and temperature-dependent variable angle spectroscopic ellipsometry measurements have been performed on plasma-deposited Linalyl Acetate thin films in order to provide insight into the compatibility of the material with current organic electronic fabrication techniques. XPS data on several substrates confirmed that the chemical properties of the thin films were substrate independent. The plasma-deposited layers were found to be insoluble in many solvents commonly used in the deposition of organic semiconducting layers, including chloroform and dichlorobenzene, and the wetting envelope for the surfaces presented. Thermal degradation was found to begin at ~200 °C, and up until this temperature the material’s thickness, refractive index and transparency in the visible region were constant. The exhibited properties show plasma-deposited Linalyl Acetate thin films to be compatible with state of the art organic electronic processing techniques.

  • temperature dependent electrical impedance spectroscopy measurements of plasma enhanced chemical vapour deposited Linalyl Acetate thin films
    Thin Solid Films, 2013
    Co-Authors: Liam J. Anderson, Mohan V. Jacob
    Abstract:

    Abstract Electrical impedance spectroscopy measurements were performed on metal–insulator–metal structures using recently developed plasma deposited thin films of Linalyl Acetate as the insulating layer between frequencies of 10 Hz and 100 kHz in order to better understand this material's dielectric and structural properties. Furthermore, measurements were performed on samples fabricated under various input energy conditions to determine whether effects induced by these conditions influence the dielectric properties. The plasma deposited Linalyl Acetate thin films were found to be low dielectric constant across a wide range of frequencies, with primary contributions from electronic factors. Neither α- nor β-relaxation peaks were observed in the frequency range investigated at room temperature and no significant dependence of dielectric properties on input energy was observed. Samples were then investigated under heated conditions at four temperatures, where a single relaxation peak was found. This peak was quite broad, indicative of the contribution of multiple relaxations to the dielectric response. The distribution of these relaxation times was determined through regularisation methods. The breakdown field was investigated for samples at three thicknesses, and found to be approximately 1.8 MV/cm.

  • electrical characterisations of plasma polyermised Linalyl Acetate
    Materials Science and Engineering B-advanced Functional Solid-state Materials, 2012
    Co-Authors: Liam J. Anderson, Mohan V. Jacob
    Abstract:

    Abstract Thin films of plasma polymerised Linalyl Acetate (PLA) were fabricated and their electrical properties investigated. The high frequency dielectric constant was determined using the split post dielectric resonator (SPDR) technique at frequencies of 10 GHz and 20 GHz and compared with the low frequency dielectric constant found from capacitive measurements of metal–insulator–metal (MIM) structures. Dielectric constants of 2.39 and 2.43 resulted from each of the respective techniques, in good agreement with each other. The J – V characteristics of MIM structures fabricated at various RF power levels were then investigated in order to determine the resistivity and DC conduction mechanism of the PLA thin films. From these data, the predominate mechanism of charge transport in the high voltage region was found to be consistent with Richardson–Schottky conduction, and the resistivity of the thin films found to increase with increasing RF power.

  • effect of a plasma polymerised Linalyl Acetate dielectric on the optical and morphological properties of an n type organic semiconductor
    Applied Physics A, 2011
    Co-Authors: Liam J. Anderson, Mohan V. Jacob, M Barra, F V Di Girolamo, A Cassinese
    Abstract:

    Thin films of the n-type, organic semiconductor PDI-8CN2 were thermally evaporated on two different dielectric surfaces and their optical and morphological properties investigated using Variable Angle Spectroscopic Ellipsometry (VASE) and Atomic Force Microscopy (AFM), respectively. The two dielectric surfaces used were SiO2 and a plasma polymer derived from the non-synthetic monomer Linalyl Acetate. The characterisations were performed in order to assess the viability of plasma polymerised Linalyl Acetate (PLA) thin films as dielectric layers in future Organic Field-Effect Transistor (OFET) devices. These studies resulted in determination of the optical profiles (refractive index and extinction coefficient) in the UV-Vis band of PDI-8CN2 grown on SiO2 and an observation of uniaxial anisotropy in the organic semiconductor. This information is useful for the design of opto-electronic devices using PDI-8CN2 layers. Variations in morphological properties and small variations optical properties were found when the PDI-8CN2 films were grown on PLA layers, and attributed to the change in surface chemistry between dielectrics.

S. La Cava - One of the best experts on this subject based on the ideXlab platform.

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