Periapical Tissue

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Syngcuk Kim - One of the best experts on this subject based on the ideXlab platform.

  • Periapical Tissue responses and cementum regeneration with amalgam supereba and mta as root end filling materials
    Journal of Endodontics, 2005
    Co-Authors: Seungho Baek, Hanns Plenk, Syngcuk Kim
    Abstract:

    The purpose of this study was to compare the Periapical Tissue responses and cementum regeneration in response to three widely used root-end filling materials, amalgam, SuperEBA, and Mineral Trioxide Aggregate (MTA). These materials were placed using modern microsurgical techniques on endodontically treated dog premolars and molars. After 5 months, the cell and Tissue reactions of surface-stained un-decalcified ground sections were evaluated by light microscopy and statistically analyzed. The major difference in the Tissue responses to the three retrofilling materials were the degree of inflammation and types of inflammatory cells, number of fibrous capsule formations, cementum neoformation over these materials, osseous healing and resulting periodontal ligament thickness. MTA showed the most favorable Periapical Tissue response, with neoformation of cemental coverage over MTA. SuperEBA was superior to amalgam as a root-end filling material.

  • Biologic properties of eugenol and zinc oxide-eugenol: A clinically oriented review
    Oral Surgery Oral Medicine Oral Pathology, 1992
    Co-Authors: Kenneth Markowitz, Michael Moynihan, M. Liu, Syngcuk Kim
    Abstract:

    Eugenol-containing dental materials are frequently used in clinical dentistry. When zinc oxide-eugenol (ZOE) is applied to a dentinal cavity, small quantities of eugenol diffuse through the dentin to the pulp. Low concentrations of eugenol exert anti-inflammatory and local anesthetic effects on the dental pulp. Thus use of ZOE temporary filling may facilitate pulpal healing; on the other hand, high eugenol concentrations are cytotoxic. Direct application of eugenol to pulp Tissue may result in extensive Tissue damage. The ability of ZOE-based endodontic sealers to influence Periapical Tissue healing is considered in view of eugenol's anti-inflammatory and toxic properties.

Hiroshi Nakamura - One of the best experts on this subject based on the ideXlab platform.

  • Histochemical localization of neutral proteases released during development of rat periradicular lesion.
    Archives of oral biology, 2009
    Co-Authors: Masahito Tsuji, Masahiro Yamasaki, Kazuharu Amano, Hironori Matsui, Taisuke Morimoto, Hiroshi Nakamura
    Abstract:

    Abstract Objective The purpose of the present study was to examine the role of various neutral proteases released during the development of periradicular lesion. Design This lesion produced by pulpal exposure of mandibular first molar in rat. The histological and histometrical changes in Periapical Tissue examined. The presence of neutrophil elastase, cathepsin G, collagenase 2, gelatinase B, and secretory leukocyte protease inhibitor (SLPI) was immunohistochemically evaluated in the Periapical Tissue. Results After pulpal exposure, some inflammatory cells were present in the Periapical Tissue at 7 days, and Periapical inflammation gradually increased. Alveolar bone resorption observed after 14 days and apical abscess found after 21 days. After 14 days, the area of periradicular lesion significantly increased compared from normal one ( p p p Conclusions These results suggested that neutrophil elastase, cathepsin G, collagenase 2, and gelatinase B induce the destruction of Periapical Tissue. We demonstrated that these neutral proteases released play an important role in development of periradicular lesion.

  • The expression of macrophage and neutrophil elastases in rat periradicular lesions.
    Journal of Endodontics, 2008
    Co-Authors: Taisuke Morimoto, Masahito Tsuji, Masahiro Yamasaki, Kazuhiko Nakata, Hiroshi Nakamura
    Abstract:

    Macrophage elastase and neutrophil elastase are involved in Tissue destruction in periradicular lesions. The purpose of this study was to examine these elastases immunohistochemically during development of periradicular lesions induced in rat mandibular first molar by pulpal exposure for 7, 14, 21, 28, and 42 days. Histologically, Periapical inflammation developed from 7 to 21 days and then subsided after 28 days. The area of these lesions gradually increased from 7 to 28 days and subsequently decreased at 42 days. Macrophage elastase was first detected at 7 days and predominantly shown from 14 to 28 days, whereas neutrophil elastase gradually increased from 14 to 28 days. Macrophage elastase was significantly greater than neutrophil elastase from 7 to 21 days. These results suggest that macrophage elastase was enhanced from an early stage during the development of these lesions and that neutrophil elastase was related to the expansion of Periapical Tissue destruction including bone resorption.

  • Irritating effect of formocresol after pulpectomy in vivo
    International Endodontic Journal, 1994
    Co-Authors: M. Yamasaki, Hiroshi Nakamura, Y. Kameyama
    Abstract:

    A study was carried out to investigate the effect of formocresol (formalin-creosote) on the Periapical Tissue after pulpectomy in rats. A pulpectomy was performed on the mesial root of the right mandibular first molar, and, in group A, a paper point containing saline was inserted into the root canal. In group B, a paper point containing formocresol was inserted, and in group C, a drop of formocresol was applied and a paper point containing formocresol was inserted into the root canal. The Periapical Tissue was examined histologically and histometrically at 3, 7, 14, and 28 days after insertion, and the inflammatory cells and fibroblasts in the apical granulation Tissue were also counted. Histologically, in group A, the inflammation observed was slight at 14 and 28 days, while in groups B and C, a moderate inflammation remained. Histometrically, the area of the apical periodontal ligament in groups B and C was increased significantly compared with that in group A at 14 and 28 days. The inflammatory cell count in groups B and C increased significantly compared with that in group A at 7, 14, and 28 days, whereas the fibroblast count in Groups B and C decreased compared with that in Group A at 7, 14, and 28 days. These results demonstrate that formocresol delayed the healing of Periapical Tissue after pulpectomy.

  • Pulpal and Periapical Tissue reactions after experimental pulpal exposure in rats.
    Journal of endodontics, 1994
    Co-Authors: Masahiro Yamasaki, Hiroshi Nakamura, Masahiko Kumazawa, Toshiaki Kohsaka, Yoichiro Kameyama
    Abstract:

    The purpose of this study was to investigate histologically and histometrically the changes in pulpal and Periapical Tissues after pulpal exposure in rats. All animals received a pulpal exposure in the left mandibular first molar. Animals were killed at 1 to 56 days after pulpal exposure, and their mandibles were evaluated histologically and histometrically. Histologically, pulpal necrosis extended gradually from the upper part of the pulpal Tissue to the apex, with inflammation starting in the Periapical Tissue at an early stage. As the Periapical lesion developed, alveolar bone and cementum resorption was also found. Histometrically, the length of pulpal necrosis increased gradually from 1 to 28 days. The vertical length of the Periapical lesion after 14 days was significantly increased, while the horizontal length and the overall area after 7 days were also significantly increased. The Periapical lesion extended in a mesiodistal direction at first and then in a vertical direction before expansion ceased.

Edward F Rossomando - One of the best experts on this subject based on the ideXlab platform.

Zhang Chen - One of the best experts on this subject based on the ideXlab platform.

  • The expression of CD14 and TLR4 in rat inflamed Periapical Tissues
    Chinese Journal of Conservative Dentistry, 2008
    Co-Authors: Zhang Chen
    Abstract:

    AIM:To explore the distribution and expression of CD14 and TLR4 in Periapical Tissue and offer the experiment foundation for elucidating the mechanisms of CD14 and TLR4 in the inflammatory reactions induced by LPS.METHODS:The model of rat molar apical periodontitis was established by placing Porphyromonas gingivalis and Porphyromonas endodontalis in the pulp chamber.The rats which pulp chambers were opened and were necrotic without bacterial were control groups.The distribution and expression of CD14 and TLR4 in Periapical Tissue were determined by immunohistochemistry technique.RESULTS:CD14 and TLR4 were strongly positively stained in inflammatory Periapical Tissue in all groups.Positive cells were mostly monocytes/macrophages.CONCLUSION:CD14 and TLR4 possibly participate in Periapical inflammatory reactions induced by LPS.

Akifumi Akamine - One of the best experts on this subject based on the ideXlab platform.

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