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Amit J Jhala - One of the best experts on this subject based on the ideXlab platform.
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control of glyphosate resistant giant Ragweed ambrosia trifida l with premix of iodosulfuron thiencarbazone applied alone or in tank mixtures in no till corn zea mays l
Canadian Journal of Plant Science, 2018Co-Authors: Simranpreet Kaur, Amit J JhalaAbstract:The objectives of this study were to evaluate the efficacy of a new premix of iodosulfuron (6%) /thiencarbazone (45%) applied alone or tank-mixed with 2,4-D, dicamba, glyphosate, or metribuzin in fall and/or early spring followed by pre-emergence (PRE) and post-emergence (POST) herbicide applications for control of glyphosate-resistant giant Ragweed and their effect on corn yield. Field experiments were conducted in no-till corn fields infested with glyphosate-resistant giant Ragweed (20 to 30 plants m─2) near Clay Center and McCool Junction, Nebraska, USA in 2013 and 2014, respectively. A premix of iodosulfuron /thiencarbazone applied alone or in split applications in fall and early spring controlled glyphosate-resistant giant Ragweed < 60% and resulted in a density of 14 giant Ragweed plants m─2, which was comparable to the nontreated control at 28 d after early spring treatment (DAEST). Metribuzin or 2,4-D applied alone resulted in < 75% giant Ragweed control at 28 DAEST; however, 2,4-D or dicamba tank...
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influence of tillage on common Ragweed ambrosia artemisiifolia emergence pattern in nebraska
Weed Technology, 2017Co-Authors: Ethann R. Barnes, Peter H. Sikkema, Lowell D Sandell, John L Lindquist, Stevan Z. Knezevic, Rodrigo Werle, Amit J JhalaAbstract:Spring tillage is a component of an integrated weed management strategy for control of early emerging glyphosate-resistant weeds such as common Ragweed; however, the effect of tillage on common Ragweed emergence pattern is unknown. The objectives of this study were to evaluate whether spring tillage during emergence would influence the emergence pattern or stimulate additional emergence of common Ragweed and to characterize common Ragweed emergence in southeast Nebraska. A field experiment was conducted for three years (2014 to 2016) in Gage County, Nebraska in a field naturally infested with glyphosate-resistant common Ragweed. Treatments consisted of a no-tillage control and three spring tillage timings. The Soil Temperature and Moisture Model (STM2) software was used to estimate soil temperature and moisture at a 2-cm depth. The Weibull function was fit to total common Ragweed emergence (%) with day of year (DOY), thermal time, and hydrothermal time as independent variables. Tillage treatments and year had no effect on total common Ragweed emergence (P = 0.88 and 0.35, respectively) and time to 10, 25, 50, 75, and 90% emergence (P = 0.31). However, emergence pattern was affected by year (P = <0.001) with 50% total emergence reached on May 5 in 2014, April 20 in 2015, and April 2 in 2016 and 90% total emergence reached on May 12, 2014, May 8, 2015, and April 30, 2016. According to the corrected information-theoretic model comparison criterion (AICc), the Weibull function with thermal time and base temperature of 3 C best explained the emergence pattern over three years. This study concludes that spring tillage does not stimulate additional emergence; therefore, after the majority of the common Ragweed has emerged and before the crop has been planted, tillage could be used as an effective component of an integrated glyphosate-resistant common Ragweed management program in Nebraska.Nomenclature: Glyphosate; common Ragweed, Ambrosia artemisiifolia L.
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Temperature Influences Efficacy, Absorption, and Translocation of 2,4-D or Glyphosate in Glyphosate-Resistant and Glyphosate-Susceptible Common Ragweed (Ambrosia artemisiifolia) and Giant Ragweed (Ambrosia trifida)
Weed Science, 2017Co-Authors: Zahoor A Ganie, Mithila Jugulam, Amit J JhalaAbstract:Glyphosate and 2,4-D have been commonly used for control of common and giant Ragweed before planting of corn and soybean in the midwestern United States. Because these herbicides are primarily applied in early spring, environmental factors such as temperature may influence their efficacy. The objectives of this study were to (1) evaluate the influence of temperature on the efficacy of 2,4-D or glyphosate for common and giant Ragweed control and the level of glyphosate resistance and (2) determine the underlying physiological mechanisms (absorption and translocation). Glyphosate-susceptible (GS) and glyphosate-resistant (GR) common and giant Ragweed biotypes from Nebraska were used for glyphosate dose–response studies, and GR biotypes were used for 2,4-D dose–response studies conducted at two temperatures (day/night [d/n]; low temperature [LT]: 20/11 C d/n; high temperature [HT]: 29/17 C d/n). Results indicate improved efficacy of 2,4-D or glyphosate at HT compared with LT for common and giant Ragweed control regardless of susceptibility or resistance to glyphosate. The level of glyphosate resistance decreased in both the species at HT compared with LT, primarily due to more translocation at HT. More translocation of 2,4-D in GR common and giant Ragweed at HT compared with LT at 96 h after treatment could be the reason for improved efficacy. Similarly, higher translocation in common Ragweed and increased absorption and translocation in giant Ragweed resulted in greater efficacy of glyphosate at HT compared with LT. It is concluded that the efficacy of 2,4-D or glyphosate for common and giant Ragweed control can be improved if applied at warm temperatures (29/17 C d/n) due to increased absorption and/or translocation compared with applications during cooler temperatures (20/11 C d/n).Nomenclature: 2,4-D, glyphosate; common Ragweed, Ambrosia artemisiifolia L.; giant Ragweed, Ambrosia trifida L.; corn, Zea mays L.; soybean, Glycine max (L.) Merr.
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glyphosate resistant common Ragweed ambrosia artemisiifolia in nebraska confirmation and response to postemergence corn and soybean herbicides
Weed Technology, 2017Co-Authors: Zahoor A Ganie, Amit J JhalaAbstract:Common Ragweed is an important broadleaf weed in agronomic crops in the northcentral United States. A common Ragweed biotype in glyphosate-resistant (GR) soybean production field in southeast Nebraska was not controlled after sequential applications of glyphosate at the labeled rate. The objectives of this study were to confirm GR common Ragweed in Nebraska by quantifying the level of resistance in greenhouse and field whole-plant dose-response studies and to evaluate the response of the putative GR common Ragweed to POST corn and soybean herbicides. Greenhouse wholeplant dose-response studies confirmed 7- and 19-fold resistance to glyphosate compared to the known glyphosate-susceptible (GS) biotype based on biomass reduction and control estimates, respectively. Field dose-response studies conducted in 2015 and 2016 at the putative GR common Ragweed research site suggested that glyphosate doses equivalent to 15- and 40-times the labeled rate (1,260 g ae ha-1) were required for 90% control and biomass redu...
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Control of Glyphosate-Resistant Common Ragweed (Ambrosia artemisiifolia L.) in Glufosinate-Resistant Soybean [Glycine max (L.) Merr]
Frontiers Media S.A., 2017Co-Authors: Ethann R. Barnes, Peter H. Sikkema, John L Lindquist, Stevan Z. Knezevic, Amit J JhalaAbstract:Common Ragweed emerges early in the season in Nebraska, USA and is competitive with soybean; therefore, preplant herbicides are important for effective control. Glyphosate has been used as a preplant control option; however, confirmation of glyphosate-resistant (GR) common Ragweed in Nebraska necessitates evaluating other herbicide options. The objectives of this study were to (1) evaluate the efficacy of preplant (PP) herbicides followed by (fb) glufosinate alone or in tank-mixture with imazethapyr, acetochlor, or S-metolachlor applied post-emergence (POST) for control of GR common Ragweed in glufosinate-resistant soybean; (2) their effect on common Ragweed density, biomass, and soybean yield; and (3) the partial economics of herbicide programs. A field experiment was conducted in a grower's field infested with GR common Ragweed in Gage County, Nebraska, USA in 2015 and 2016. Preplant herbicide programs containing glufosinate, paraquat, 2,4-D, dimethenamid-P, cloransulam-methyl, or high rates of flumioxazin plus chlorimuron-ethyl provided 90–99% control of common Ragweed at 21 d after treatment (DAT). The aforementioned PP herbicides fb a POST application of glufosinate alone or in tank-mixture with imazethapyr, acetochlor, or S-metolachlor controlled GR common Ragweed 84–98% at soybean harvest, reduced common Ragweed density (≤20 plants m−2) and biomass by ≥93%, and secured soybean yield 1,819–2,158 kg ha−1. The PP fb POST herbicide programs resulted in the highest gross profit margins (US$373–US$506) compared to PP alone (US$91) or PRE fb POST programs (US$158). The results of this study conclude that effective and economical control of GR common Ragweed in glufosinate-resistant soybean is achievable with PP fb POST herbicide programs
Peter H. Sikkema - One of the best experts on this subject based on the ideXlab platform.
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influence of tillage on common Ragweed ambrosia artemisiifolia emergence pattern in nebraska
Weed Technology, 2017Co-Authors: Ethann R. Barnes, Peter H. Sikkema, Lowell D Sandell, John L Lindquist, Stevan Z. Knezevic, Rodrigo Werle, Amit J JhalaAbstract:Spring tillage is a component of an integrated weed management strategy for control of early emerging glyphosate-resistant weeds such as common Ragweed; however, the effect of tillage on common Ragweed emergence pattern is unknown. The objectives of this study were to evaluate whether spring tillage during emergence would influence the emergence pattern or stimulate additional emergence of common Ragweed and to characterize common Ragweed emergence in southeast Nebraska. A field experiment was conducted for three years (2014 to 2016) in Gage County, Nebraska in a field naturally infested with glyphosate-resistant common Ragweed. Treatments consisted of a no-tillage control and three spring tillage timings. The Soil Temperature and Moisture Model (STM2) software was used to estimate soil temperature and moisture at a 2-cm depth. The Weibull function was fit to total common Ragweed emergence (%) with day of year (DOY), thermal time, and hydrothermal time as independent variables. Tillage treatments and year had no effect on total common Ragweed emergence (P = 0.88 and 0.35, respectively) and time to 10, 25, 50, 75, and 90% emergence (P = 0.31). However, emergence pattern was affected by year (P = <0.001) with 50% total emergence reached on May 5 in 2014, April 20 in 2015, and April 2 in 2016 and 90% total emergence reached on May 12, 2014, May 8, 2015, and April 30, 2016. According to the corrected information-theoretic model comparison criterion (AICc), the Weibull function with thermal time and base temperature of 3 C best explained the emergence pattern over three years. This study concludes that spring tillage does not stimulate additional emergence; therefore, after the majority of the common Ragweed has emerged and before the crop has been planted, tillage could be used as an effective component of an integrated glyphosate-resistant common Ragweed management program in Nebraska.Nomenclature: Glyphosate; common Ragweed, Ambrosia artemisiifolia L.
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Control of Glyphosate-Resistant Common Ragweed (Ambrosia artemisiifolia L.) in Glufosinate-Resistant Soybean [Glycine max (L.) Merr]
Frontiers Media S.A., 2017Co-Authors: Ethann R. Barnes, Peter H. Sikkema, John L Lindquist, Stevan Z. Knezevic, Amit J JhalaAbstract:Common Ragweed emerges early in the season in Nebraska, USA and is competitive with soybean; therefore, preplant herbicides are important for effective control. Glyphosate has been used as a preplant control option; however, confirmation of glyphosate-resistant (GR) common Ragweed in Nebraska necessitates evaluating other herbicide options. The objectives of this study were to (1) evaluate the efficacy of preplant (PP) herbicides followed by (fb) glufosinate alone or in tank-mixture with imazethapyr, acetochlor, or S-metolachlor applied post-emergence (POST) for control of GR common Ragweed in glufosinate-resistant soybean; (2) their effect on common Ragweed density, biomass, and soybean yield; and (3) the partial economics of herbicide programs. A field experiment was conducted in a grower's field infested with GR common Ragweed in Gage County, Nebraska, USA in 2015 and 2016. Preplant herbicide programs containing glufosinate, paraquat, 2,4-D, dimethenamid-P, cloransulam-methyl, or high rates of flumioxazin plus chlorimuron-ethyl provided 90–99% control of common Ragweed at 21 d after treatment (DAT). The aforementioned PP herbicides fb a POST application of glufosinate alone or in tank-mixture with imazethapyr, acetochlor, or S-metolachlor controlled GR common Ragweed 84–98% at soybean harvest, reduced common Ragweed density (≤20 plants m−2) and biomass by ≥93%, and secured soybean yield 1,819–2,158 kg ha−1. The PP fb POST herbicide programs resulted in the highest gross profit margins (US$373–US$506) compared to PP alone (US$91) or PRE fb POST programs (US$158). The results of this study conclude that effective and economical control of GR common Ragweed in glufosinate-resistant soybean is achievable with PP fb POST herbicide programs
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control of glyphosate resistant giant Ragweed ambrosia trifida l with isoxaflutole and metribuzin tankmix
American Journal of Plant Sciences, 2016Co-Authors: Scott Ditschun, Nader Soltani, Darren E. Robinson, François J. Tardif, Allan C Kaastra, Peter H. SikkemaAbstract:Five field trials were conducted over a two-year period (2013, 2014) to determine the control of glyphosate-resistant (GR) giant Ragweed with isoxaflutole (IFT) and metribuzin (MTZ) applied alone and in combination. Treatments were designed to assess the dose response of an IFT plus MTZ tank-mix as well as each chemical applied alone to classify the response using Flint’s adaptation of Colby’s equation. Two factor factorial experiments were performed in the growth room to ascertain the response of IFT versus glyphosate, IFT versus MTZ, and IFT plus MTZ versus glyphosate on single plants. Field experiments evaluated the control of GR giant Ragweed with IFT plus MTZ in tank-mix in a 1:4 ratio. The rate of IFT plus MTZ for 80% control of GR giant Ragweed at 4 and 8 weeks after application (WAA) was 518 (104 g a.i. ha-1 IFT + 414 g a.i. ha-1 MTZ) and 631 g a.i. ha-1 (126 g a.i. ha-1 IFT + 505 g a.i. ha-1 MTZ), respectively. A rate of 668 and 467 g a.i. ha-1 was required to reduce GR giant Ragweed density and biomass by 80%, respectively. Field experiments evaluating the control of GR giant Ragweed with tank-mixes of IFT plus MTZ, where glyphosate was a constant tank-mix partner, were mostly synergistic. However, the low tank-mix rate (52.5 + 210 g a.i. ha-1) had an additive response for GR giant Ragweed biomass reduction. When tested in the greenhouse and growth room, glyphosate susceptible (GS) giant Ragweed showed some antagonism with glyphosate and isoxaflutole tank-mixes at rates less than commercial field rates. GR giant Ragweed showed an additive response across all treatments in the growth room. Greenhouse experiments evaluating IFT versus MTZ and IFT plus MTZ versus glyphosate revealed all tank-mix treatments to be synergistic at 2 WAA.
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glyphosate resistant common Ragweed ambrosia artemisiifolia control with postemergence herbicides and glyphosate dose response in soybean in ontario
Weed Technology, 2015Co-Authors: Annemarie C Van Wely, Darren E. Robinson, Mark B. Lawton, David C Hooker, N Soltani, Peter H. SikkemaAbstract:Abstract Field trials were conducted in Ontario in 2013 and 2014 in soybean to determine the efficacy of POST herbicides on common Ragweed resistant to group 2 and group 9 herbicides. Glyphosate dose-response experiments were conducted in the field on two resistant common Ragweed populations and one susceptible population. None of the POST herbicides evaluated provided 80% control of glyphosate-resistant (GR) common Ragweed. The most effective POST herbicide mixture was glyphosate (Monsanto Canada Inc., 67 Scurfield Blvd., Winnipeg, Manitoba, Canada) plus fomesafen(Syngenta Canada Inc., 140 Research Lane, Research Park Guelph, Ontario, Canada), which provided 68 to 98% control of GR common Ragweed. Chlorimuron, cloransulam, imazethapyr, and thifensulfuron provided control similar to glyphosate alone. An application of glyphosate/fomesafen reduced biomass by as much as 95%. Glyphosate plus acifluorfen reduced GR common Ragweed biomass by as much as 92%. The remaining POST herbicide tank mixes evaluated red...
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control of glyphosate and acetolactate synthase resistant common Ragweed ambrosia artemisiifolia l in soybean glycine max l with preplant herbicides
American Journal of Plant Sciences, 2014Co-Authors: Annemarie C Van Wely, Nader Soltani, Darren E. Robinson, Mark B. Lawton, David C Hooker, Peter H. SikkemaAbstract:A population of common Ragweed in Ontario was confirmed to be resistant to glyphosate in 2011. Group 2 [acetolactate synthase (ALS) inhibitors] resistant common Ragweed was first confirmed in Ontario in 2000. Previously, glyphosate provided excellent control of common Ragweed in glyphosate resistant soybean but with the confirmation of glyphosate resistant (GR) common Ragweed, alternative herbicides need to be evaluated. Eight field trials with preplant herbicides were completed over two years (2013 and 2014) in fields with confirmed GR common Ragweed. Tank-mixes of glyphosate and linuron or metribuzin provided 88% - 99% and 86% - 98% control 4 weeks after application (WAA) and 80% - 92% and 80% - 95% control 8 WAA, respectively. However, these herbicides also had among the highest environmental impact of the herbicides tested. Based on the results of these studies, GR common Ragweed can be controlled with residual herbicides when applied preemergence in soybean. Currently, there are no post emergence herbicides that provide adequate control of GR common Ragweed, therefore, preemergence herbicides with residual are essential for full season control.
Hendrik Nolte - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of standardized short Ragweed sublingual immunotherapy tablet slit t treatment in canadian subjects with Ragweed pollen induced rhinitis with or without conjunctivitis
Allergy Asthma & Clinical Immunology, 2014Co-Authors: Michael S Blaiss, Hendrik Nolte, Jacques Hebert, Amarjot Kaur, Jennifer Maloney, Peter S Creticos, Harold Kim, Harold S Nelson, Susan WasermanAbstract:Background Efficacy of standardized short Ragweed sublingual immunotherapy tablet (SLIT-T), MK-3641 (Merck/ALK; 12 Amb a 1-U of Ambrosia artemisiifolia) treatment on Canadian Ragweed-allergic subjects was assessed using subgroup analysis of data from 2 multinational, randomized, double-blind, placebo-controlled clinical trials designed to evaluate Ragweed SLIT-T efficacy and safety in adults with Ragweed pollen-induced allergic rhinitis with or without conjunctivitis (AR/C), with or without asthma.
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randomized controlled trial of Ragweed allergy immunotherapy tablet efficacy and safety in north american adults
Annals of Allergy Asthma & Immunology, 2013Co-Authors: Hendrik Nolte, Jacques Hebert, Gary Berman, Sandra Gawchik, Martha V White, Amarjot Kaur, Nancy Liu, William R Lumry, Jennifer MaloneyAbstract:Abstract Background Ragweed is an important cause of allergic rhinitis with or without conjunctivitis (AR/C) in North America and elsewhere. Allergen immunotherapy enabling safe patient self-administration is considered an unmet clinical need. Allergy immunotherapy tablet (AIT) treatment has shown promising efficacy and safety for grass allergy but has not been assessed for Ragweed allergy. Objective To evaluate efficacy and safety of 2 short Ragweed AIT doses in patients with AR/C. Methods Adults with Ragweed pollen–induced AR/C were randomized 1:1:1 to daily Ragweed AIT (6 or 12 Amb a 1 units) or placebo before, throughout, and after Ragweed season (approximately 52 weeks). Patients could use predefined allergy rescue medications in season. Efficacy end points included peak and entire season total combined score (TCS) and its components daily symptom score (DSS), and daily medication score (DMS). Safety assessments included adverse events. Results A total of 565 patients were randomized. During peak season, the 6– and 12–Amb a 1 unit Ragweed AIT doses showed 21% (−1.76 score) and 27% (−2.24 score) improvement in TCS vs placebo ( P P Conclusion In this trial, Ragweed AIT was effective and well tolerated in Ragweed-allergic North American adults. Trial Registration clinicaltrials.gov Identifier: NCT00783198.
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randomized controlled trial of a Ragweed allergy immunotherapy tablet in north american and european adults
The Journal of Allergy and Clinical Immunology, 2013Co-Authors: Peter S Creticos, Amarjot Kaur, Nancy Liu, Jennifer Maloney, David I Bernstein, Thomas B Casale, Robert S Fisher, Kevin R Murphy, Kristof Nekam, Hendrik NolteAbstract:Background In North America and Europe, millions of patients experience symptoms of allergic rhinitis with or without conjunctivitis (AR/C) on exposure to Ragweed pollen. The disease burden can be significant, with most patients relying on symptomatic medications without disease-modifying potential. However, novel sublingual immunomodulatory treatment options may potentially play an important role if efficacy and side effect profiles allow the convenience of self-administration. Objectives This study evaluated an allergy immunotherapy tablet (AIT; SCH 39641/MK-3641) for treatment of Ragweed-induced AR/C in the first large randomized, double-blind multinational trial of this therapeutic modality for Ragweed allergy. Methods Adults (n = 784) with short Ragweed-induced AR/C were randomly assigned to approximately 52 weeks of daily self-administered Ragweed AIT of 1.5, 6, or 12 units of Ambrosia artemisiifolia major allergen 1 (Amb a 1-U) or placebo. Subjects could use as-needed allergy rescue medication. Symptoms and medications were recorded daily. The primary efficacy end point was total combined daily symptom/medication score (TCS) during peak Ragweed season. Safety was monitored through adverse event diaries maintained through study duration. Results During peak Ragweed season, Ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 9% (−0.76; P = .22), 19% (−1.58; P = .01), and 24% (−2.04; P = .002) compared with placebo. During the entire season, Ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 12% (−0.88; P = .09), 18% (−1.28; P = .01), and 27% (−1.92; P Conclusions In this trial, Ragweed AIT of 12 Amb a 1-U was effective and tolerable with a safety profile that permitted daily self-administration of Ragweed allergen immunotherapy.
Jean Bousquet - One of the best experts on this subject based on the ideXlab platform.
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Patterns in Google Trends Terms Reporting Rhinitis and Ragweed Pollen Season in Ukraine
International Archives of Allergy and Immunology, 2019Co-Authors: Igor Kaidashev, Halyna Morokhovets, Viktoriia Rodinkova, Jean BousquetAbstract:Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Ragweed pollen allergy was investigated due to its high allergenicity and wide expansion in Europe. Objectives: The study aimed to examine translations of "Ragweed" and "hay fever" in native Cyrillic languages, especially in Ukrainian and Russian, and to compare the seasonality of queries in Ukraine with Ragweed and mugwort pollen counts. Methods: We used GT to search Google queries concerning Ragweed allergy: "allergy," "hay fever," "running nose," "Ragweed," "asthma," and "pollen." The Cyrillic terms in Ukrainian and Russian were used. Pollen collection for 2013-2015 was conducted using volumetric methods. Average daily temperatures were obtained from the website http://gismeteo.ua. Correlations were studied by using Pearson and Spearman tests. Results: GT queries profile had the "B" pattern according to the classification developed by Bousquet et al. [Allergy. 2017 Aug; 72(8): 1261-6]. A peak of "Ragweed" queries was observed after the maximum of average daily temperature. The terms "allergy," "hay fever," and "Ragweed" in Cyrillic are required in Ukraine to calculate the Ragweed pollen exposure by GT. The Ragweed pollen season started with a concentration of pollen grains of 12.95 m-3. The Artemisia pollen season started between 19 and 25 days before the beginning of the Ambrosia pollen season. Conclusions: GT may be a useful tool in the differentiation of the pollen seasons, especially when they overlap as in the case of Arte misia/Ambrosia. Three terms, "allergy," "hay fever," and "Ragweed" (in Cyrillic equivalents), are required in Ukraine to account for Ragweed pollen exposure. The combination of GT tools with pollen counts may be used in large-scale epidemiological studies.
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Differences in Reporting the Ragweed Pollen Season Using Google Trends across 15 Countries
International Archives of Allergy and Immunology, 2018Co-Authors: Jean Bousquet, Ioana Agache, Uwe Berger, Karl-christian Bergmann, Jean-pierre Besancenot, Philippe Bousquet, Tom Casale, Gennaro D'amato, Igor Kaidashev, Musa KhaitovAbstract:BACKGROUND: Google Trends (GT) searches trends of specific queries in Google, which potentially reflect the real-life epidemiology of allergic rhinitis. We compared GT terms related to Ragweed pollen allergy in American and European Union countries with a known Ragweed pollen season. Our aim was to assess seasonality and the terms needed to perform the GT searches and to compare these during the spring and summer pollen seasons. METHODS: We examined GT queries from January 1, 2011, to January 4, 2017. We included 15 countries with a known Ragweed pollen season and used the standard 5-year GT graphs. We used the GT translation for all countries and the untranslated native terms for each country. RESULTS: The results of "pollen," "Ragweed," and "allergy" searches differed between countries, but "Ragweed" was clearly identified in 12 of the 15 countries. There was considerable heterogeneity of findings when the GT translation was used. For Croatia, Hungary, Romania, Serbia, and Slovenia, the GT translation was inappropriate. The country patterns of "pollen," "hay fever," and "allergy" differed in 8 of the 11 countries with identified "Ragweed" queries during the spring and the summer, indicating that the perception of tree and grass pollen allergy differs from that of Ragweed pollen. CONCLUSIONS: To investigate Ragweed pollen allergy using GT, the term "Ragweed" as a plant is required and the translation of "Ragweed" in the native language needed.
Jennifer Maloney - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of standardized short Ragweed sublingual immunotherapy tablet slit t treatment in canadian subjects with Ragweed pollen induced rhinitis with or without conjunctivitis
Allergy Asthma & Clinical Immunology, 2014Co-Authors: Michael S Blaiss, Hendrik Nolte, Jacques Hebert, Amarjot Kaur, Jennifer Maloney, Peter S Creticos, Harold Kim, Harold S Nelson, Susan WasermanAbstract:Background Efficacy of standardized short Ragweed sublingual immunotherapy tablet (SLIT-T), MK-3641 (Merck/ALK; 12 Amb a 1-U of Ambrosia artemisiifolia) treatment on Canadian Ragweed-allergic subjects was assessed using subgroup analysis of data from 2 multinational, randomized, double-blind, placebo-controlled clinical trials designed to evaluate Ragweed SLIT-T efficacy and safety in adults with Ragweed pollen-induced allergic rhinitis with or without conjunctivitis (AR/C), with or without asthma.
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randomized controlled trial of Ragweed allergy immunotherapy tablet efficacy and safety in north american adults
Annals of Allergy Asthma & Immunology, 2013Co-Authors: Hendrik Nolte, Jacques Hebert, Gary Berman, Sandra Gawchik, Martha V White, Amarjot Kaur, Nancy Liu, William R Lumry, Jennifer MaloneyAbstract:Abstract Background Ragweed is an important cause of allergic rhinitis with or without conjunctivitis (AR/C) in North America and elsewhere. Allergen immunotherapy enabling safe patient self-administration is considered an unmet clinical need. Allergy immunotherapy tablet (AIT) treatment has shown promising efficacy and safety for grass allergy but has not been assessed for Ragweed allergy. Objective To evaluate efficacy and safety of 2 short Ragweed AIT doses in patients with AR/C. Methods Adults with Ragweed pollen–induced AR/C were randomized 1:1:1 to daily Ragweed AIT (6 or 12 Amb a 1 units) or placebo before, throughout, and after Ragweed season (approximately 52 weeks). Patients could use predefined allergy rescue medications in season. Efficacy end points included peak and entire season total combined score (TCS) and its components daily symptom score (DSS), and daily medication score (DMS). Safety assessments included adverse events. Results A total of 565 patients were randomized. During peak season, the 6– and 12–Amb a 1 unit Ragweed AIT doses showed 21% (−1.76 score) and 27% (−2.24 score) improvement in TCS vs placebo ( P P Conclusion In this trial, Ragweed AIT was effective and well tolerated in Ragweed-allergic North American adults. Trial Registration clinicaltrials.gov Identifier: NCT00783198.
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randomized controlled trial of a Ragweed allergy immunotherapy tablet in north american and european adults
The Journal of Allergy and Clinical Immunology, 2013Co-Authors: Peter S Creticos, Amarjot Kaur, Nancy Liu, Jennifer Maloney, David I Bernstein, Thomas B Casale, Robert S Fisher, Kevin R Murphy, Kristof Nekam, Hendrik NolteAbstract:Background In North America and Europe, millions of patients experience symptoms of allergic rhinitis with or without conjunctivitis (AR/C) on exposure to Ragweed pollen. The disease burden can be significant, with most patients relying on symptomatic medications without disease-modifying potential. However, novel sublingual immunomodulatory treatment options may potentially play an important role if efficacy and side effect profiles allow the convenience of self-administration. Objectives This study evaluated an allergy immunotherapy tablet (AIT; SCH 39641/MK-3641) for treatment of Ragweed-induced AR/C in the first large randomized, double-blind multinational trial of this therapeutic modality for Ragweed allergy. Methods Adults (n = 784) with short Ragweed-induced AR/C were randomly assigned to approximately 52 weeks of daily self-administered Ragweed AIT of 1.5, 6, or 12 units of Ambrosia artemisiifolia major allergen 1 (Amb a 1-U) or placebo. Subjects could use as-needed allergy rescue medication. Symptoms and medications were recorded daily. The primary efficacy end point was total combined daily symptom/medication score (TCS) during peak Ragweed season. Safety was monitored through adverse event diaries maintained through study duration. Results During peak Ragweed season, Ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 9% (−0.76; P = .22), 19% (−1.58; P = .01), and 24% (−2.04; P = .002) compared with placebo. During the entire season, Ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 12% (−0.88; P = .09), 18% (−1.28; P = .01), and 27% (−1.92; P Conclusions In this trial, Ragweed AIT of 12 Amb a 1-U was effective and tolerable with a safety profile that permitted daily self-administration of Ragweed allergen immunotherapy.
