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David M Ribnicky - One of the best experts on this subject based on the ideXlab platform.
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qualitative variation of anti diabetic compounds in different Tarragon artemisia dracunculus l cytotypes
Fitoterapia, 2011Co-Authors: Sasha W Eisenman, Ilya Raskin, Alexander Poulev, Lena Struwe, David M RibnickyAbstract:Abstract Ethanolic extracts of diploid Artemisia dracunculus L. (wild Tarragon) from populations in the U.S., and polyploid Tarragon from a variety of sources, were screened for the anti-diabetic compounds davidigenin; sakuranetin; 2’,4’-dihydroxy-4-methoxydihydrochalcone; 4,5-di-O-caffeoylquinic acid; 5-O-caffeoylquinic acid and 6-demethoxycapillarisin using LC-MS. Only decaploid plants contained all six target compounds and were the only plants that contained davidigenin and 2,4-dihydroxy-4-methoxydihydrochalcone. These results exhibit the importance of germplasm selection and provenance when studying plants for medicinal activity. Relying only on the “right species” for consistent medicinal activities may not be sufficient, as intraspecific variation may be highly significant.
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the effect of russian Tarragon artemisia dracunculus l on the plasma creatine concentration with creatine monohydrate administration
Journal of The International Society of Sports Nutrition, 2008Co-Authors: Ralf Jager, David M Ribnicky, Iain P Kendrick, Martin Purpura, R C Harris, Ivo PischelAbstract:Background It has previously been shown that the plasma concentration of creatine following supplementation is influenced by extracellular concentrations of insulin and glucose, the form in which creatine is administered, and also the creatine concentration in the muscle cells. The common practice of raising insulin levels to increase initial uptake into muscle, by means of high amounts of glucose and/or protein, involves a high caloric load which is not always desired by athletes. A standardized extract of Russian Tarragon (Artemisia dracunculus L.), which can be administered safely as an oral supplement, has been shown to have antihyperglycemic activity. This study examined whether the plasma concentration curve following administration of creatine monohydrate was affected by the co-administration of Russian Tarragon extract.
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polyphenolic compounds from artemisia dracunculus l inhibit pepck gene expression and gluconeogenesis in an h4iie hepatoma cell line
American Journal of Physiology-endocrinology and Metabolism, 2007Co-Authors: Dmitry Govorko, Sithes Logendra, David M Ribnicky, Alexander Poulev, Debora Esposito, Slavko Komarnytsky, Zhong Q Wang, William T. Cefalu, Yanxin Wang, Ilya RaskinAbstract:An ethanolic extract of Russian Tarragon, Artemisia dracunculus L., with antihyperglycemic activity in animal models was reported to decrease phosphoenolpyruvate carboxykinase (PEPCK) mRNA expressi...
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toxicological evaluation of the ethanolic extract of artemisia dracunculus l for use as a dietary supplement and in functional foods
Food and Chemical Toxicology, 2004Co-Authors: David M Ribnicky, Alexander Poulev, Joseph M Oneal, Gary Wnorowski, Dolores E Malek, Ralf Jager, Ilya RaskinAbstract:TARRALIN™ is an ethanolic extract of Artemisia dracunculus (Russian Tarragon), a common medicinal and culinary herb with centuries of use. Artemisia dracunculus is a close relative of the French or cooking Tarragon and contains components common to many herbs that are routinely consumed without reported adverse effects. Since safety information of Artemisia dracunculus and its extract is limited to historical use, TARRALIN™ was examined in a series of toxicological studies. Complete Ames analysis did not reveal any mutagenic activity either with or without metabolic activation. TARRALIN™ was tested in an acute limit test at 5000 mg/kg with no signs of toxicity noted. In a 14 day repeated dose oral toxicity study, rats appeared to well tolerate 1000 mg/kg/day. Subsequently, TARRALIN™ was tested in an oral subchronic 90-day toxicity study (rat) at doses of 10, 100 and 1000 mg/kg/day. No noteworthy signs of toxicity were noted in feeding or body weight, functional observational battery or motor activity. Gross necropsy and clinical chemistry did not reveal any effects on organ mass or blood chemistry and microscopic examinations found no lesions associated with treatment. Therefore, TARRALIN™ appears to be safe and non-toxic in these studies and a no-observed adverse effect level in rats is established at 1000 mg/kg/day.
Akbar Arabhosseini - One of the best experts on this subject based on the ideXlab platform.
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effects of ultrasound pre treatment on quantity and quality of essential oil of Tarragon artemisia dracunculus l leaves
Journal of Applied Research on Medicinal and Aromatic Plants, 2017Co-Authors: Leila Bahmani, Mohammad Aboonajmi, Akbar Arabhosseini, Hossein MirsaeedghaziAbstract:Abstract Hydro-distillation with ultrasound was used for extraction of essential oil of Tarragon (Artemisia dracunculus L.) leaves. The results of this method were compared with a traditional distillation method considering the extraction kinetics as well as the physicochemical and antioxidant properties of the essential oil. The experiments were ran at three sound power levels (250, 350 and 500 W), three levels of sonication time (20, 30 and 40 min) as well as without sonication as a control in a completely randomized design with three replications. Gas chromatography was used to identify the essential oil compounds. Antioxidant properties were studied using the reducing DPPH radical method. The statistical results showed that the effect of ultrasound power on the essences extracted was not significant. The effect of sonication time on the essential oil content was significant at the 5% level. The highest amount of extracted oil was observed at the power of 500 W for 30 min while the lowest amount was found at 500W for 40 min. The highest percentage of estragole, which is the most important compound of Tarragon was achieved with the proposed method. The highest antioxidant activity was for the extracted essential oil using ultrasound pre-treatment with 350 W power for 30 min and the control samples showed the lowest level.
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effect of drying on the color of Tarragon artemisia dracunculus l leaves
Food and Bioprocess Technology, 2011Co-Authors: Akbar Arabhosseini, Sudhakar Padhye, Willem Huisman, Anton J B Van Boxtel, Joachim MullerAbstract:The effect of drying conditions on the color of Tarragon (Artemisia dracunculus L.) leaves was studied. Tarragon leaves were dried at temperatures of 40 to 90 °C with a constant airflow of 0.6 m/s. The samples were collected at 7%, 10%, 20%, and 30% moisture content wet basis for evaluation of the color change. The color parameters of fresh and dried leaves were measured by a colorimeter. The individual parameters of L*a*b* and L*C*h° color systems were evaluated and h° proved to be the best parameter to monitor color change. The smallest change of the color parameters was observed at 40 °C, in which temperature was low, and also at 90 °C, when drying time was short. The biggest change occurred at the temperatures of 50 to 70 °C. Most of the color change happened before the material reaches 35% moisture content. The combination of drying time and temperature defines the change of color.
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long term effects of drying conditions on the essential oil and color of Tarragon leaves during storage
Journal of Food Engineering, 2007Co-Authors: Akbar Arabhosseini, Anton J B Van Boxtel, W Huisman, Joachim MullerAbstract:Abstract The effect of storage on the essential oil content and color of French Tarragon ( Artemisia dracunculus L.) leaves is studied. Tarragon leaves were dried at temperatures 45, 60 and 90 °C with, respectively, the relative humidity levels 17%, 7% and 2.5%. At 60 °C also a relative humidity level of 18% was applied. The air velocity was constant at 0.6 m/s. Oil content and color were measured for the fresh and dried leaves just after drying as well as after storage during 15, 30, 60 and 120 days. The essential oil compounds of the material were isolated by the hydro-distillation method and analyzed by GC–FID as well as GC–MS. A Chroma meter was used to measure the color of the samples. The results showed a reduction of the oil content and changed color parameters during the storage period. The largest changes of the essential oil content (about 50% after 30 days) and color expressed by the hue value was found for the material dried at 90 °C. Drying at 45 °C resulted in the smallest quality changes.
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loss of essential oil of Tarragon artemisia dracunculus l due to drying
Journal of the Science of Food and Agriculture, 2006Co-Authors: Sudhakar Padhye, Willem Huisman, Anton J B Van Boxtel, Teris A Van Beek, M A Posthumus, Akbar Arabhosseini, Joachim MullerAbstract:The effect of hot air-drying on the essential oil constituents and yield in French and Russian Tarragon (Artemisia dracunculus L.) leaves was studied. The Tarragon leaves were dried at air temperatures ranging from 40 to 90 °C. The drying stopped when the moisture content of the samples reached 10% or for some of the treatments reached 7, 20 and 30%. The essential oil of the fresh and dried leaves was isolated by hydrodistillation and analysed by capillary gas chromatography and gas chromatography-mass spectrometry. The decrease of oil during the drying process was highest at 60 °C drying temperature. For French Tarragon the decrease in the amount of oil was significantly lower at 90 °C. The effect of the relative humidity of the drying air at each temperature was not significant. The main compounds were estragole in French Tarragon (69%) and sabinene in Russian Tarragon (40%). The drying process changed the relative percentage of the constituents in the oil; for instance, the relative percentages of estragole decreased and sabinene increased in French Tarragon
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Modeling of the Equilibrium Moisture Content (EMC) of Tarragon (Artemisia Dracunculus L.)
International Journal of Food Engineering, 2005Co-Authors: Akbar Arabhosseini, Anton Van Boxtel, Willem Huisman, J. MüllerAbstract:The equilibrium moisture content of Tarragon, Artemisia dracunculus L. (stem and leaf separately) was determined by using the saturated salt solutions method at three temperatures (25, 50 and 70°C) within a range of 5 to 90% relative humidity. Both adsorption and desorption methods were used for stem and leaf of two varieties: Russian and French Tarragon. Experimental curves of moisture sorption isotherms were fitted by modified Henderson, modified Halsey, modified Oswin, modified Chung-Pfost and GAB equations and evaluated by residual sum squares, standard error of estimate and mean relative deviation. The modified Halsey and GAB equations were found to be the most suitable for describing the relationship among equilibrium moisture content, relative humidity and temperature. There was no significant difference between the equilibrium moisture content of the Russian and French Tarragon.
Sasha W Eisenman - One of the best experts on this subject based on the ideXlab platform.
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essential oil diversity in north american wild Tarragon artemisia dracunculus l with comparisons to french and kyrgyz Tarragon
Industrial Crops and Products, 2013Co-Authors: Sasha W Eisenman, Lena Struwe, Rodolfo H Juliani, James E SimonAbstract:Abstract Although Artemisia dracunculus is a native species widely distributed across western North America, the essential oil composition of plants from this region has not been as extensively studied as its Asian populations. Essential oil extracted from 63 cultivated individuals of this species, originating from 18 different diploid North American wild populations, one cultivated octoploid individual from seed collected in Kyrgyzstan, and five cultivated tetraploid French Tarragon plants, were analyzed by gas chromatography–mass spectroscopy. The diploid individuals exhibited a variety of volatile profiles with major components including (Z)-β-ocimene (22 samples), methyl eugenol (15 individuals), methyl chavicol (10 individuals) and α-terpinolene (5 individuals). Many of the samples had high concentrations of the polylacetylenes capillene, 5-phenyl-1,3-pentadiyne and 1-(4-methoxyphenyl)-2,4-pentadiyne. The isocoumarin acetylene, capillarin, was also found in the majority of (53) samples but was generally found in low amounts (less than 4%). The volatile oil from tetraploid French Tarragon samples contained approximately 80% methyl chavicol. The octoploid sample from Kyrgyzstan was found to have a unique profile with its main constituents being myrcene, (Z)-artemidin and limonene. Six major clusters were formed in the UPGMA cluster analysis and showed groups rich in (1) methyl chavicol, (2) methyl eugenol, (3) α-terpinolene, (4) capillene, (5) 5-phenyl-1,3-pentadiyne and (6) (E)-β-ocimene/(Z)-β-ocimene. These results show that North American wild Tarragon is a potential source for unique oils and can serve as sources of genetic materials in plant breeding.
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The global distribution of wild Tarragon (Artemisia dracunculus L.; Asteraceae) cytotypes with twenty-seven new records from North America
Genetic Resources and Crop Evolution, 2011Co-Authors: Sasha W Eisenman, Lena StruweAbstract:Artemisia dracunculus (wild or Russian Tarragon), is a polymorphic, herbaceous perennial with a widespread distribution that spans western North America, Eastern Europe and most temperate of Asia. This wild relative of the culinary herb French Tarragon has recently been the focus of a number of studies which have investigated its medicinal activity in type 2 diabetes bioassays. The species is documented as having from diploid to decaploid cytotypes and chemical variation has previously been shown to occur between cytotypes. To help focus germplasm collecting efforts for ongoing studies on variation of medicinal compounds within the species, a literature review of the geographical occurrences of cytotypes was conducted. This review revealed a lack of records from North America. In order to fill in this gap in the cytogeographic distribution, meiotic chromosome counts and flow cytometry were used to determine the ploidy level of 27 individuals from 16 different populations throughout the western United States. The results revealed distinct patterns of cytotype distribution. Both diploids and polyploid cytotypes were found in Eurasia, and the distributional range of each cytotype was found to be increasingly restricted as ploidy increased. For North America, even with the inclusion of many new records, only diploid populations were documented, with the exception of one hexaploid record from Arizona which was found in the literature.
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qualitative variation of anti diabetic compounds in different Tarragon artemisia dracunculus l cytotypes
Fitoterapia, 2011Co-Authors: Sasha W Eisenman, Ilya Raskin, Alexander Poulev, Lena Struwe, David M RibnickyAbstract:Abstract Ethanolic extracts of diploid Artemisia dracunculus L. (wild Tarragon) from populations in the U.S., and polyploid Tarragon from a variety of sources, were screened for the anti-diabetic compounds davidigenin; sakuranetin; 2’,4’-dihydroxy-4-methoxydihydrochalcone; 4,5-di-O-caffeoylquinic acid; 5-O-caffeoylquinic acid and 6-demethoxycapillarisin using LC-MS. Only decaploid plants contained all six target compounds and were the only plants that contained davidigenin and 2,4-dihydroxy-4-methoxydihydrochalcone. These results exhibit the importance of germplasm selection and provenance when studying plants for medicinal activity. Relying only on the “right species” for consistent medicinal activities may not be sufficient, as intraspecific variation may be highly significant.
Ilya Raskin - One of the best experts on this subject based on the ideXlab platform.
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qualitative variation of anti diabetic compounds in different Tarragon artemisia dracunculus l cytotypes
Fitoterapia, 2011Co-Authors: Sasha W Eisenman, Ilya Raskin, Alexander Poulev, Lena Struwe, David M RibnickyAbstract:Abstract Ethanolic extracts of diploid Artemisia dracunculus L. (wild Tarragon) from populations in the U.S., and polyploid Tarragon from a variety of sources, were screened for the anti-diabetic compounds davidigenin; sakuranetin; 2’,4’-dihydroxy-4-methoxydihydrochalcone; 4,5-di-O-caffeoylquinic acid; 5-O-caffeoylquinic acid and 6-demethoxycapillarisin using LC-MS. Only decaploid plants contained all six target compounds and were the only plants that contained davidigenin and 2,4-dihydroxy-4-methoxydihydrochalcone. These results exhibit the importance of germplasm selection and provenance when studying plants for medicinal activity. Relying only on the “right species” for consistent medicinal activities may not be sufficient, as intraspecific variation may be highly significant.
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polyphenolic compounds from artemisia dracunculus l inhibit pepck gene expression and gluconeogenesis in an h4iie hepatoma cell line
American Journal of Physiology-endocrinology and Metabolism, 2007Co-Authors: Dmitry Govorko, Sithes Logendra, David M Ribnicky, Alexander Poulev, Debora Esposito, Slavko Komarnytsky, Zhong Q Wang, William T. Cefalu, Yanxin Wang, Ilya RaskinAbstract:An ethanolic extract of Russian Tarragon, Artemisia dracunculus L., with antihyperglycemic activity in animal models was reported to decrease phosphoenolpyruvate carboxykinase (PEPCK) mRNA expressi...
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toxicological evaluation of the ethanolic extract of artemisia dracunculus l for use as a dietary supplement and in functional foods
Food and Chemical Toxicology, 2004Co-Authors: David M Ribnicky, Alexander Poulev, Joseph M Oneal, Gary Wnorowski, Dolores E Malek, Ralf Jager, Ilya RaskinAbstract:TARRALIN™ is an ethanolic extract of Artemisia dracunculus (Russian Tarragon), a common medicinal and culinary herb with centuries of use. Artemisia dracunculus is a close relative of the French or cooking Tarragon and contains components common to many herbs that are routinely consumed without reported adverse effects. Since safety information of Artemisia dracunculus and its extract is limited to historical use, TARRALIN™ was examined in a series of toxicological studies. Complete Ames analysis did not reveal any mutagenic activity either with or without metabolic activation. TARRALIN™ was tested in an acute limit test at 5000 mg/kg with no signs of toxicity noted. In a 14 day repeated dose oral toxicity study, rats appeared to well tolerate 1000 mg/kg/day. Subsequently, TARRALIN™ was tested in an oral subchronic 90-day toxicity study (rat) at doses of 10, 100 and 1000 mg/kg/day. No noteworthy signs of toxicity were noted in feeding or body weight, functional observational battery or motor activity. Gross necropsy and clinical chemistry did not reveal any effects on organ mass or blood chemistry and microscopic examinations found no lesions associated with treatment. Therefore, TARRALIN™ appears to be safe and non-toxic in these studies and a no-observed adverse effect level in rats is established at 1000 mg/kg/day.
Joachim Muller - One of the best experts on this subject based on the ideXlab platform.
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effect of drying on the color of Tarragon artemisia dracunculus l leaves
Food and Bioprocess Technology, 2011Co-Authors: Akbar Arabhosseini, Sudhakar Padhye, Willem Huisman, Anton J B Van Boxtel, Joachim MullerAbstract:The effect of drying conditions on the color of Tarragon (Artemisia dracunculus L.) leaves was studied. Tarragon leaves were dried at temperatures of 40 to 90 °C with a constant airflow of 0.6 m/s. The samples were collected at 7%, 10%, 20%, and 30% moisture content wet basis for evaluation of the color change. The color parameters of fresh and dried leaves were measured by a colorimeter. The individual parameters of L*a*b* and L*C*h° color systems were evaluated and h° proved to be the best parameter to monitor color change. The smallest change of the color parameters was observed at 40 °C, in which temperature was low, and also at 90 °C, when drying time was short. The biggest change occurred at the temperatures of 50 to 70 °C. Most of the color change happened before the material reaches 35% moisture content. The combination of drying time and temperature defines the change of color.
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long term effects of drying conditions on the essential oil and color of Tarragon leaves during storage
Journal of Food Engineering, 2007Co-Authors: Akbar Arabhosseini, Anton J B Van Boxtel, W Huisman, Joachim MullerAbstract:Abstract The effect of storage on the essential oil content and color of French Tarragon ( Artemisia dracunculus L.) leaves is studied. Tarragon leaves were dried at temperatures 45, 60 and 90 °C with, respectively, the relative humidity levels 17%, 7% and 2.5%. At 60 °C also a relative humidity level of 18% was applied. The air velocity was constant at 0.6 m/s. Oil content and color were measured for the fresh and dried leaves just after drying as well as after storage during 15, 30, 60 and 120 days. The essential oil compounds of the material were isolated by the hydro-distillation method and analyzed by GC–FID as well as GC–MS. A Chroma meter was used to measure the color of the samples. The results showed a reduction of the oil content and changed color parameters during the storage period. The largest changes of the essential oil content (about 50% after 30 days) and color expressed by the hue value was found for the material dried at 90 °C. Drying at 45 °C resulted in the smallest quality changes.
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loss of essential oil of Tarragon artemisia dracunculus l due to drying
Journal of the Science of Food and Agriculture, 2006Co-Authors: Sudhakar Padhye, Willem Huisman, Anton J B Van Boxtel, Teris A Van Beek, M A Posthumus, Akbar Arabhosseini, Joachim MullerAbstract:The effect of hot air-drying on the essential oil constituents and yield in French and Russian Tarragon (Artemisia dracunculus L.) leaves was studied. The Tarragon leaves were dried at air temperatures ranging from 40 to 90 °C. The drying stopped when the moisture content of the samples reached 10% or for some of the treatments reached 7, 20 and 30%. The essential oil of the fresh and dried leaves was isolated by hydrodistillation and analysed by capillary gas chromatography and gas chromatography-mass spectrometry. The decrease of oil during the drying process was highest at 60 °C drying temperature. For French Tarragon the decrease in the amount of oil was significantly lower at 90 °C. The effect of the relative humidity of the drying air at each temperature was not significant. The main compounds were estragole in French Tarragon (69%) and sabinene in Russian Tarragon (40%). The drying process changed the relative percentage of the constituents in the oil; for instance, the relative percentages of estragole decreased and sabinene increased in French Tarragon
