The Experts below are selected from a list of 276 Experts worldwide ranked by ideXlab platform
Elena Kokoliou - One of the best experts on this subject based on the ideXlab platform.
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Basic Skin Parameters
internal, 2017Co-Authors: Elena KokoliouAbstract:) Magnetic resonance imaging (MRI) What do we know about Skin Microcirculation? There is greater capillary density in the head-face/neck region than
M Baron - One of the best experts on this subject based on the ideXlab platform.
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Reliability of widefield Capillary microscopy to measure nailfold Capillary Density in systemic sclerosis.
Clinical and experimental rheumatology, 2010Co-Authors: M Hudson, A Masetto, R Steele, E Arthurs, M BaronAbstract:To determine intra- and inter-observer reliability of widefield microscopy to measure nailfold Capillary Density in patients with systemic sclerosis (SSc). Five SSc patients were examined with a STEMV-8 Zeiss biomicroscope with 50x magnification. The nailfold of the second, third, fourth and fifth fingers of both hands of each patient were photographed twice by each of two observers, once in the morning and again in the afternoon (total of 32 pictures). Two raters reviewed the photographs to produce Capillary Density readings. Intra- and inter-rater reliability of the readings were computed using intra-class correlations (ICC). Additional analyses were undertaken to determine the impact of other sources of variability in the data, namely patient, finger, technician and time. Intra-and inter-rater reliability were substantial (ICC 0.72-0.84) when raters were reading the same photographs or photographs taken at the same time of day. Agreement was only fair between morning and afternoon Density readings (ICC 0.30-0.37). Patients, individual fingers and technician accounted for a large part of the variability in the data (combined variance component of 7.69 out of the total 12.23). The coefficient of variation of widefield microscopy was 24%. Although intra- and inter-rater reliability of nailfold Capillary Density measurements using widefield microscopy are good, proper standardisation of the conditions under which capillaroscopy is done and better imaging of nailfold Capillary abnormalities should be considered if nailfold Capillary Density is to be used as an outcome measure in multi-centre clinical trials in SSc.
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Reliability of widefield Capillary microscopy to measure nailfold Capillary Density in systemic sclerosis.
Clinical and Experimental Rheumatology, 2010Co-Authors: M Hudson, A Masetto, R Steele, E Arthurs, M BaronAbstract:Objectives. To determine intra- and inter-observer reliability of wi d e field microscopy to measure nailfold Capillary Density in patients with systemic sclerosis (SSc). Methods. Five SSc patients were examined with a STEMV-8 Zeiss biomicroscope with 50x magnification. The nailfold of the second, third, fourth and fifth fingers of both hands of each patient were photographed twice by each of two observers, once in the morning and again in the afternoon (total of 32 pictures). Two raters reviewed the photographs to produce Capillary Density readings. Intra- and inter-rater reliability of the readings were computed using intra-class correlations (ICC). Additional analyses were undertaken to determine the impact of other sources of variability in the data, namely patient, finger, technician and time. Results. Intra-and inter-rater reliability were substantial (ICC 0.72-0.84) when raters were reading the same photographs or photographs taken at the same time of day. Agreement was only fair between morning and afternoon Density readings (ICC 0.30-0.37). Patients, individual fingers and technician accounted for a large part of the variability in the data (combined variance component of 7.69 out of the total 12.23). The coefficient of variation of widefield microscopy was 24%. Conclusion. Although intra- and inter-rater reliability of nailfold Capillary Density measurements using widefield microscopy are good, proper standardisation of the conditions under which capillaroscopy is done and better imaging of nailfold Capillary abnormalities should be considered if nailfold Capillary Density is to be used as an outcome measure in multi-centre clinical trials in SSc.
Brian H Annex - One of the best experts on this subject based on the ideXlab platform.
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relationship between leg muscle Capillary Density and peak hyperemic blood flow with endurance capacity in peripheral artery disease
Journal of Applied Physiology, 2011Co-Authors: Jennifer L Robbins, Schuyler W Jones, Brian D Duscha, Jason D Allen, William E Kraus, Judith G Regensteiner, William R Hiatt, Brian H AnnexAbstract:The aim of this study was to determine if skeletal muscle Capillary Density is lower in patients with peripheral artery disease (PAD) and if Capillary Density relates to functional limitations. PAD...
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Relationship between leg muscle Capillary Density and peak hyperemic blood flow with endurance capacity in peripheral artery disease.
Journal of applied physiology (Bethesda Md. : 1985), 2011Co-Authors: Jennifer L Robbins, Brian D Duscha, Jason D Allen, William E Kraus, Judith G Regensteiner, William R Hiatt, W. Schuyler Jones, Brian H AnnexAbstract:The aim of this study was to determine if skeletal muscle Capillary Density is lower in patients with peripheral artery disease (PAD) and if Capillary Density relates to functional limitations. PAD patients with intermittent claudication (IC) have a decreased exercise tolerance due to exercise-induced muscle ischemia. Despite the apparent role diminished arterial flow has in this population, the degree of walking pain and functional limitation is not entirely explained by altered hemodynamics of the affected limbs. We hypothesized that skeletal muscle Capillary Density is lower in PAD and is related to the functional impairment observed in this population. Sixty-four patients with PAD and 56 controls underwent cardiopulmonary exercise testing and a gastrocnemius muscle biopsy. A subset of these patients (48 PAD and 47 controls) underwent peak hyperemic flow testing via plethysmography. Capillary Density in PAD patients was lower compared with controls (P < 0.001). After adjustment for several baseline demographic imbalances the model relating Capillary Density to peak oxygen consumption (Vo(2)) remained significant (P < 0.001). In PAD subjects, Capillary Density correlated with peak Vo(2), peak walking time (PWT), and claudication onset time (COT). Peak hyperemic blood flow related to peak Vo(2) in both PAD and control subjects. PAD is associated with lower Capillary Density, and Capillary Density is related to the functional impairment as defined by a reduced peak Vo(2), PWT, and COT. These findings suggest that alterations in microcirculation may contribute to functional impairment capacity in PAD.
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A sex-specific relationship between Capillary Density and anaerobic threshold
Journal of applied physiology (Bethesda Md. : 1985), 2009Co-Authors: Jennifer L Robbins, Brian D Duscha, Brian H Annex, Daniel Bensimhon, Karlman Wasserman, James E. Hansen, Joseph A. Houmard, William E KrausAbstract:Although both Capillary Density and peak oxygen consumption (Vo2) improve with exercise training, it is difficult to find a relationship between these two measures. It has been suggested that peak...
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relationship of physical function to vastus lateralis Capillary Density and metabolic enzyme activity in elderly men and women
Aging Clinical and Experimental Research, 2008Co-Authors: Barbara J Nicklas, Brian H Annex, Iris Leng, Osvaldo Delbono, Dalane W Kitzman, Anthony P Marsh, Gregory W Hundley, Mary F Lyles, Kenneth S Orourke, William E KrausAbstract:Background and aims: There are no data showing whether or not age-related declines in physical function are related to in vitro properties of human skeletal muscle. The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults. Methods: The study was a cross-sectional observational study of 39 sedentary, older (60–85 yrs) men and women. A needle biopsy of the vastus lateralis for assessment of muscle fiber type, fiber area, Capillary Density and citrate synthase and aldolase activities was performed. Physical function tests included the Short Physical Performance Battery (balance, walking speed, and chair rise time), as well as self-reported disability. Results: Total fiber area (R=−0.41, p=0.02), number of Type II fibers (R=− 0.33, p=0.05), and aldolase activity (R=−0.54, p=0.01) were inversely related to age. Persons who reported greater difficulty with daily activities had lower Capillary Density (R=−0.51, p=0.03) and lower citrate synthase activity (R=−0.66, p=0.03). Walking speed was directly related to fiber area (R=0.40, p=0.02), Capillary Density (R=0.39, p=0.03), citrate synthase (R=0.45, p=0.03) and aldolase (R=0.55, p<0.01) activities, even after adjustment for age, BMI and disease status. Conclusions: In older adults, skeletal muscle Capillary Density and metabolic enzymatic activity are independent predictors of lower extremity physical function.
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Relationship of physical function to vastus lateralis Capillary Density and metabolic enzyme activity in elderly men and women
Aging clinical and experimental research, 2008Co-Authors: Barbara J Nicklas, Brian H Annex, Iris Leng, Osvaldo Delbono, Dalane W Kitzman, Anthony P Marsh, Mary F Lyles, W. Gregory Hundley, Kenneth S. O'rourke, William E KrausAbstract:Background and aims: There are no data showing whether or not age-related declines in physical function are related to in vitro properties of human skeletal muscle. The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults. Methods: The study was a cross-sectional observational study of 39 sedentary, older (60–85 yrs) men and women. A needle biopsy of the vastus lateralis for assessment of muscle fiber type, fiber area, Capillary Density and citrate synthase and aldolase activities was performed. Physical function tests included the Short Physical Performance Battery (balance, walking speed, and chair rise time), as well as self-reported disability. Results: Total fiber area (R=−0.41, p=0.02), number of Type II fibers (R=− 0.33, p=0.05), and aldolase activity (R=−0.54, p=0.01) were inversely related to age. Persons who reported greater difficulty with daily activities had lower Capillary Density (R=−0.51, p=0.03) and lower citrate synthase activity (R=−0.66, p=0.03). Walking speed was directly related to fiber area (R=0.40, p=0.02), Capillary Density (R=0.39, p=0.03), citrate synthase (R=0.45, p=0.03) and aldolase (R=0.55, p
M Hudson - One of the best experts on this subject based on the ideXlab platform.
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Reliability of widefield Capillary microscopy to measure nailfold Capillary Density in systemic sclerosis.
Clinical and experimental rheumatology, 2010Co-Authors: M Hudson, A Masetto, R Steele, E Arthurs, M BaronAbstract:To determine intra- and inter-observer reliability of widefield microscopy to measure nailfold Capillary Density in patients with systemic sclerosis (SSc). Five SSc patients were examined with a STEMV-8 Zeiss biomicroscope with 50x magnification. The nailfold of the second, third, fourth and fifth fingers of both hands of each patient were photographed twice by each of two observers, once in the morning and again in the afternoon (total of 32 pictures). Two raters reviewed the photographs to produce Capillary Density readings. Intra- and inter-rater reliability of the readings were computed using intra-class correlations (ICC). Additional analyses were undertaken to determine the impact of other sources of variability in the data, namely patient, finger, technician and time. Intra-and inter-rater reliability were substantial (ICC 0.72-0.84) when raters were reading the same photographs or photographs taken at the same time of day. Agreement was only fair between morning and afternoon Density readings (ICC 0.30-0.37). Patients, individual fingers and technician accounted for a large part of the variability in the data (combined variance component of 7.69 out of the total 12.23). The coefficient of variation of widefield microscopy was 24%. Although intra- and inter-rater reliability of nailfold Capillary Density measurements using widefield microscopy are good, proper standardisation of the conditions under which capillaroscopy is done and better imaging of nailfold Capillary abnormalities should be considered if nailfold Capillary Density is to be used as an outcome measure in multi-centre clinical trials in SSc.
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Reliability of widefield Capillary microscopy to measure nailfold Capillary Density in systemic sclerosis.
Clinical and Experimental Rheumatology, 2010Co-Authors: M Hudson, A Masetto, R Steele, E Arthurs, M BaronAbstract:Objectives. To determine intra- and inter-observer reliability of wi d e field microscopy to measure nailfold Capillary Density in patients with systemic sclerosis (SSc). Methods. Five SSc patients were examined with a STEMV-8 Zeiss biomicroscope with 50x magnification. The nailfold of the second, third, fourth and fifth fingers of both hands of each patient were photographed twice by each of two observers, once in the morning and again in the afternoon (total of 32 pictures). Two raters reviewed the photographs to produce Capillary Density readings. Intra- and inter-rater reliability of the readings were computed using intra-class correlations (ICC). Additional analyses were undertaken to determine the impact of other sources of variability in the data, namely patient, finger, technician and time. Results. Intra-and inter-rater reliability were substantial (ICC 0.72-0.84) when raters were reading the same photographs or photographs taken at the same time of day. Agreement was only fair between morning and afternoon Density readings (ICC 0.30-0.37). Patients, individual fingers and technician accounted for a large part of the variability in the data (combined variance component of 7.69 out of the total 12.23). The coefficient of variation of widefield microscopy was 24%. Conclusion. Although intra- and inter-rater reliability of nailfold Capillary Density measurements using widefield microscopy are good, proper standardisation of the conditions under which capillaroscopy is done and better imaging of nailfold Capillary abnormalities should be considered if nailfold Capillary Density is to be used as an outcome measure in multi-centre clinical trials in SSc.
Eduardo Tibiriçá - One of the best experts on this subject based on the ideXlab platform.
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Increased functional and structural skin Capillary Density in type 1 diabetes patients with vascular complications.
Diabetology & metabolic syndrome, 2009Co-Authors: Eduardo Tibiriçá, Elba Rodrigues, Roberta A Cobas, Marília B. GomesAbstract:The present study was designed to study skin Capillary Density and recruitment of the upper and lower extremities in patients with type 1 diabetes with vascular complications, when compared to patients without complications and healthy subjects. We used intravital video-microscopy to measure basal and maximal (during venous congestion) skin Capillary densities as well as Capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers and toes. Our results showed that besides microvascular vasodilation and loss of autoregulatory capacity, patients with type 1 diabetes with vascular complications present increased skin Capillary Density in both extremities.
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Increased skin Capillary Density in treated essential hypertensive patients.
American journal of hypertension, 2006Co-Authors: Haythem Debbabi, Laurent Uzan, Jean-jacques Mourad, Michel E. Safar, Bernard I. Levy, Eduardo TibiriçáAbstract:Background Microvascular rarefaction is a hallmark of essential hypertension. We measured the skin Capillary Density in nondiabetic hypertensive subjects with effective antihypertensive treatment and evaluated possible correlations with arterial blood pressure (BP). Methods This cross-sectional observational study included 76 (55 ± 1 years) consecutive outpatients with essential hypertension under chronic antihypertensive drug treatment (BP Results Baseline and maximal Capillary densities (number/mm2) were significantly lower (59.6 ± 2.0 and 62.0 ± 1.9) in untreated than in treated hypertensive patients (74.0 ± 1.4 and 79.4 ± 1.5; P Conclusions In nondiabetic hypertensive patients, Capillary Density is reduced in association with a cluster of cardiovascular risk factors involving tobacco consumption and obesity. The finding of an increased Capillary Density in effectively treated antihypertensives suggests that a cause-to-effect relationship between BP and Capillary Density should be evaluated in a long-term prospective follow-up.
