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Érika Cristina Ribeiro De Lima Carneiro - One of the best experts on this subject based on the ideXlab platform.

  • Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease.
    International journal of nephrology and renovascular disease, 2020
    Co-Authors: Raimunda Sheyla Carneiro Dias, Dyego José De Araújo Brito, Elisângela Milhomem Dos Santos, Rayanna Cadilhe De Oliveira Costa, Andrea Martins Melo Fontenele, Elane Viana Hortegal Furtado, Joyce Santos Lages, Alcione Miranda Dos Santos, Elton Jonh Freitas Santos, Érika Cristina Ribeiro De Lima Carneiro
    Abstract:

    Background Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate parathyroid hormone (PTH) levels with urinary magnesium Excretion in patients with non-dialysis dependent CKD. Methods Cross-sectional study. Concentrations of creatinine, magnesium, calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily Excretion and by the Excretion Fraction (FEMg). Results The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (>89.5pg/mL), the mean levels of FEMg and ALP were higher (p

Valerio Podio - One of the best experts on this subject based on the ideXlab platform.

  • Semi-quantitative analysis of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: a first-line tool
    Clinical Oral Investigations, 2017
    Co-Authors: Tiziana Angusti, Emanuela Pilati, Antonella Parente, Renato Carignola, Matteo Manfredi, Simona Cauda, Elena Pizzigati, Julien Dubreuil, Francesco Giammarile, Valerio Podio
    Abstract:

    Objective The aim of this study was the assessment of semi-quantified salivary gland dynamic scintigraphy (SGdS) parameters independently and in an integrated way in order to predict primary Sjögren’s syndrome (pSS). Materials and methods Forty-six consecutive patients (41 females; age 61 ± 11 years) with sicca syndrome were studied by SGdS after injection of 200 MBq of pertechnetate. In sixteen patients, pSS was diagnosed, according to American-European Consensus Group criteria (AECGc). Semi-quantitative parameters (uptake (UP) and Excretion Fraction (EF)) were obtained for each gland. ROC curves were used to determine the best cut-off value. The area under the curve (AUC) was used to estimate the accuracy of each semi-quantitative analysis. To assess the correlation between scintigraphic results and disease severity, semi-quantitative parameters were plotted versus Sjögren’s syndrome disease activity index (ESSDAI). A nomogram was built to perform an integrated evaluation of all the scintigraphic semi-quantitative data. Results Both UP and EF of salivary glands were significantly lower in pSS patients compared to those in non-pSS ( p  

Iván Ferraz-amaro - One of the best experts on this subject based on the ideXlab platform.

  • The validity of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: comparison of visual and Excretion Fraction analyses
    Clinical Rheumatology, 2020
    Co-Authors: María García-gonzález, M. Jesús González-soto, M. Ángeles Gómez Rodríguez-bethencourt, Iván Ferraz-amaro
    Abstract:

    Objectives The diagnostic validity of salivary gland scintigraphy in Sjögren’s syndrome (SS) has not been conclusively defined. Whether a quantitative (Excretion Fraction) interpretation of scintigraphy is superior to a qualitative one (visual analysis) remains a matter of debate. We sought to determine whether the diagnostic discrimination of Excretion Fraction is higher compared to that obtained by visual analysis. Methods Diagnostic test validity study that encompassed 137 suspected SS subjects who underwent scintigraphy for diagnostic purposes. Patients were diagnosed as SS and non-SS according to the rheumatologist’s clinical judgment, and by using the American-European Consensus Group (AECG) and American College of Rheumatology (ACR) classification criteria. Visual analysis (normal vs. abnormal and Schall’s classification grade) and Excretion Fraction scores were calculated. The diagnostic discrimination of these methods was compared through the area under the curve (AUC) analysis. Scintigraphy associations with SS clinical and laboratory features were assessed through multivariable regression analysis. Results Schall’s classification AUC reached statistical significance in its diagnostic discrimination for SS clinical judgment (0.704 [95%CI 0.597–0.811]) and AECG criteria (0.764 [95%CI 0.641–0.886]). Similarly, submandibular Excretion Fraction was associated with SS diagnosis based on ACR (0.737 [95%CI 0.546–0.931]) and AECG criteria (0.715 [95%CI 0.597–0.833]). However, AUC comparisons between qualitative and quantitative methods did not yield statistically significant values. Both interpretation modalities were associated with SS serological features. Moreover, Excretion Fraction was also associated with salivary gland biopsy. Conclusions SS diagnostic discrimination of Excretion Fraction is not superior to that obtained by qualitative visual analysis. Both qualitative and quantitative scintigraphy methods are associated with SS clinical and laboratory characteristics.

  • The validity of salivary gland scintigraphy in Sjögren's syndrome diagnosis: comparison of visual and Excretion Fraction analyses.
    Clinical rheumatology, 2020
    Co-Authors: María García-gonzález, M. Jesús González-soto, M. Ángeles Gómez Rodríguez-bethencourt, Iván Ferraz-amaro
    Abstract:

    Objectives The diagnostic validity of salivary gland scintigraphy in Sjogren's syndrome (SS) has not been conclusively defined. Whether a quantitative (Excretion Fraction) interpretation of scintigraphy is superior to a qualitative one (visual analysis) remains a matter of debate. We sought to determine whether the diagnostic discrimination of Excretion Fraction is higher compared to that obtained by visual analysis. Methods Diagnostic test validity study that encompassed 137 suspected SS subjects who underwent scintigraphy for diagnostic purposes. Patients were diagnosed as SS and non-SS according to the rheumatologist's clinical judgment, and by using the American-European Consensus Group (AECG) and American College of Rheumatology (ACR) classification criteria. Visual analysis (normal vs. abnormal and Schall's classification grade) and Excretion Fraction scores were calculated. The diagnostic discrimination of these methods was compared through the area under the curve (AUC) analysis. Scintigraphy associations with SS clinical and laboratory features were assessed through multivariable regression analysis. Results Schall's classification AUC reached statistical significance in its diagnostic discrimination for SS clinical judgment (0.704 [95%CI 0.597-0.811]) and AECG criteria (0.764 [95%CI 0.641-0.886]). Similarly, submandibular Excretion Fraction was associated with SS diagnosis based on ACR (0.737 [95%CI 0.546-0.931]) and AECG criteria (0.715 [95%CI 0.597-0.833]). However, AUC comparisons between qualitative and quantitative methods did not yield statistically significant values. Both interpretation modalities were associated with SS serological features. Moreover, Excretion Fraction was also associated with salivary gland biopsy. Conclusions SS diagnostic discrimination of Excretion Fraction is not superior to that obtained by qualitative visual analysis. Both qualitative and quantitative scintigraphy methods are associated with SS clinical and laboratory characteristics.

  • The Validity of Salivary Gland Scintigraphy in Sjögren’s Syndrome Diagnosis: Comparison of Visual and Excretion Fraction Analysis
    2020
    Co-Authors: María García-gonzález, M. Ángeles Gómez Rodríguez-bethencourt, María Jesús González Soto, Iván Ferraz-amaro
    Abstract:

    Abstract Introduction. The diagnostic value of salivary gland scintigraphy (SGS) in Sjögren’s syndrome (SS) is not completely known. Whether qualitative or quantitative methods of SGS interpretation are the most appropriate remains a matter of debate. We sought to determine whether the diagnostic discrimination of quantitative Excretion Fraction is higher compared to SGS qualitative visual analysis in a cohort of subjects with suspected SS. Materials and methods. Cross-sectional study that encompassed 204 subjects who underwent SGS for potential SS diagnosis. Based on clinical judgement, three groups were established: SS, non-SS autoimmune diseases (AID non-SS) and neither SS nor other AID (non-AID). In addition, American-European Consensus Group -AECG- and American College of Rheumatology -ACR- criteria were applied. Qualitative diagnosis through visual analysis -normal vs. abnormal and Schall’s classification grade- and semiquantitative and quantitative Excretion Fraction (EF%) scores were established following SGS assessment. The diagnostic discrimination of the different SGS scores for the various SS diagnostic modalities (clinical judgement and AECG and ACR criteria) was compared through their areas under the curve (AUC). Results. Most SGS parameters were significantly associated with SS-related clinical and laboratory features. Schall’s grade ≥ III was significantly more frequent in SS than in non-SS patients. In general, EF%-derived parameters did not show significant differences between groups. AUC of Schall’s classification reached statistical significance in its diagnostic discrimination for SS clinical judgement (AUC 0.704 [95%CI 0.597–0.811], p = 0.000) and AECG criteria (AUC 0.764 [95%CI 0.641–0.886], p = 0.000). Similarly the EF% submandibular mean (AUC 0.737 [95%CI 0.546–0.931] p = 0.032) was significantly associated with SS diagnosis through ACR criteria. However, AUC comparisons between qualitative and quantitative methods did not yield significant values. Conclusion. SS diagnostic discrimination of EF% is not superior to that obtained by qualitative visual analysis.

Devika Poddalgoda - One of the best experts on this subject based on the ideXlab platform.

  • Derivation of biomonitoring equivalents (BE values) for bismuth.
    Regulatory toxicology and pharmacology : RTP, 2020
    Co-Authors: Devika Poddalgoda, Sean M Hays, Andy Nong
    Abstract:

    Bismuth (Bi) is a natural element present in the environmental media. Bismuth has been used medicinally for centuries, specifically for the treatment of gastrointestinal (GI) disorders. Although bismuth toxicity is rare in humans, an outbreak of bismuth-induced neurotoxicity was reported in France and Australia in the mid-1970s. The primary source of bismuth exposure in the general population is via food. US FDA (2019) estimated recommended daily intake (RDI) for bismuth as 848 mg bismuth/day (12.1 mg Bi/kg-d assuming a body weight of 70 kg) for GI tract disorders. Exposures to bismuth can be quantified by measuring concentrations in blood and urine. Biomonitoring equivalents (BEs) were derived based on US FDA's RDI as a tool for interpretation of population-level biomonitoring data. A regression between steady state plasma concentrations and oral intakes was used to derive plasma BEs. A whole blood: plasma partitioning coefficient of 0.6 was used to convert plasma BE into whole blood BE. A mass balance equation with a urinary Excretion Fraction of 0.0003 was used to derive urinary BE. The BE values associated with US FDA's RDI for plasma, whole blood and urine were 8.0, 4.8 and 0.18 μg/L, respectively. These BE values together with bismuth biomonitoring data may be used in screening and prioritization of health risk assessment of bismuth in the general population.

  • Biomonitoring Equivalents for interpretation of urinary iodine.
    Regulatory toxicology and pharmacology : RTP, 2018
    Co-Authors: Sean M Hays, Devika Poddalgoda, Kristin Macey, Lesa Aylward, Andy Nong
    Abstract:

    Iodine is an essential nutrient whose deficiency or excess exposure can cause adverse health effects. The primary sources of iodine exposure in the general population are iodized salt, dairy products, bread and sea food. Urinary iodine concentrations (UIC) have been measured by Canadian Health Measures Survey (CHMS) and US National Health and Nutrition Examination Survey (NHANES). The Institute of Medicine (IOM), the US Agency for Toxic Substances and Disease Registry (ATSDR) and World Health Organization (WHO) have established exposure guidance values for nutrition (IOM Estimated Average Requirement (EAR), Recommended Dietary Allowance (RDA), WHO Recommended Nutrient Intake (RNI)) and toxicity (IOM Tolerable Upper Intake Level (UL); ATSDR Minimal Risk Level (MRL), WHO International Programme on Chemical Safety (IPCS) Tolerable Daily Intake (TDI)). Using a urinary Excretion Fraction of 0.9, Biomonitoring Equivalents (BE) for the EAR, RDA, UL and MRL were derived for adults (60, 100, 730 and 450 μg/L, respectively) and children (50, 80, 580 and 360 μg/L, respectively). The population median UIC values from NHANES and CHMS for adults (140-181, 122-126 μg/L, respectively) and children (232, 189 μg/L, respectively) were above the criteria for assessing iodine nutrition, indicating that US and Canadian populations are likely to have adequate population iodine nutrition. The median UIC from NHANES and CHMS do not exceed BE values derived from exposure guidance values for toxicity.

  • Development of biomonitoring equivalents for barium in urine and plasma for interpreting human biomonitoring data.
    Regulatory toxicology and pharmacology : RTP, 2017
    Co-Authors: Devika Poddalgoda, Kristin Macey, Henry Assad, Kannan Krishnan
    Abstract:

    The objectives of the present work were: (1) to assemble population-level biomonitoring data to identify the concentrations of urinary and plasma barium across the general population; and (2) to derive biomonitoring equivalents (BEs) for barium in urine and plasma in order to facilitate the interpretation of barium concentrations in the biological matrices. In population level biomonitoring studies, barium has been measured in urine in the U.S. (NHANES study), but no such data on plasma barium levels were identified. The BE values for plasma and urine were derived from U.S. EPA's reference dose (RfD) of 0.2 mg/kg bw/d, based on a lower confidence limit on the benchmark dose (BMDL05) of 63 mg/kg bw/d. The plasma BE (9 μg Ba/L) was derived by regression analysis of the near-steady-state plasma concentrations associated with the administered doses in animals exposed to barium chloride dihydrate in drinking water for 2-years in a NTP study. Using a human urinary Excretion Fraction of 0.023, a BE for urinary barium (0.19 mg/L or 0.25 mg/g creatinine) was derived for US EPA's RfD. The median and the 95th percentile barium urine concentrations of the general population in U.S. are below the BE determined in this study, indicating that the population exposure to inorganic barium is expected to be below the exposure guidance value of 0.2 mg/kg bw/d.

  • Derivation of biomonitoring equivalent for inorganic tin for interpreting population-level urinary biomonitoring data
    Regulatory toxicology and pharmacology : RTP, 2016
    Co-Authors: Devika Poddalgoda, Kristin Macey, Innocent Jayawardene, Kannan Krishnan
    Abstract:

    Population-level biomonitoring of tin in urine has been conducted by the U.S. National Health and Nutrition Examination Survey (NHANES) and the National Nutrition and Health Study (ENNS - Etude nationale nutrition sante) in France. The general population is predominantly exposed to inorganic tin from the consumption of canned food and beverages. The National Institute for Public Health and the Environment of the Netherlands (RIVM) has established a tolerable daily intake (TDI) for chronic exposure to inorganic tin based on a NOAEL of 20 mg/kg bw per day from a 2-year feeding study in rats. Using a urinary Excretion Fraction (0.25%) from a controlled human study along with a TDI value of 0.2 mg/kg bw per day, a Biomonitoring Equivalent (BE) was derived for urinary tin (26 μg/g creatinine or 20 μg/L urine). The geometric mean and the 95th percentile tin urine concentrations of the general population in U.S. (0.705 and 4.5 μg/g creatinine) and France (0.51 and 2.28 μg/g creatinine) are below the BE associated with the TDI, indicating that the population exposure to inorganic tin is below the exposure guidance value of 0.2 mg/kg bw per day. Overall, the robustness of pharmacokinetic data forming the basis of the urinary BE development is medium. The availability of internal dose and kinetic data in the animal species forming the basis of the assessment could improve the overall confidence in the present assessment.

Yoshihiko Sasaki - One of the best experts on this subject based on the ideXlab platform.

  • magnetic resonance sialography and salivary gland scintigraphy of parotid glands in sjogren s syndrome
    The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association, 2018
    Co-Authors: Ichiro Ogura, Yoshihiko Sasaki, Kazuhide Hayama
    Abstract:

    OBJECTIVE: To assess the correlation between conventional magnetic resonance (MR) imaging and MR sialography of parotid glands with salivary gland scintigraphy in patients with Sjogren's syndrome. METHODS: A retrospective study was conducted on eight patients with Sjogren's syndrome who underwent MR imaging and salivary gland scintigraphy. Conventional MR imaging techniques, such as T1-weighted images (T1WI), T2-weighted images (T2WI), and short TI inversion recovery images (STIR) were used for changes of fat signal in the parotid gland, while the MR sialography were used for ducts dilation of the parotid gland. Regarding scintigraphy, time-activity curves of each parotid gland were analysed. The salivary gland Excretion Fraction was defined as A (before stimulation test (counts/20 s)) and B (after stimulation test (counts/20 s)). RESULTS: Regarding characteristic appearances of fat signal, the A/B of parotid gland with homogeneous intensity distribution (3.51 ± 0.75) was higher than that with heterogeneous intensity distribution (1.56 ± 0.66, P = 0.001). Regarding MR sialographic stages, the A/B of parotid gland with stage 0 (3.51 ± 0.75) was higher than that with stage 1 (2.03 ± 0.86, P = 0.009) and with stage 2 (1.26 ± 0.25, P = 0.000). CONCLUSION: The results suggest that MR sialography of the parotid glands is a useful noninvasive tool for evaluating the decrease of salivary gland Excretion in patients with Sjogren's syndrome.

  • submandibular sialolithiasis with ct and scintigraphy ct values and salivary gland Excretion in the submandibular glands
    Imaging Science in Dentistry, 2017
    Co-Authors: Ichiro Ogura, Kazuhide Hayama, Yoshihiko Sasaki
    Abstract:

    Purpose: Sialolithiasis is one of the most prevalent large obstructive disorders of the submandibular glands. The aim of this study was to investigate submandibular sialolithiasis with computed tomography (CT) and scintigraphy, with a particular focus on the relationship between CT values of the submandibular glands and their Excretion rate. Materials and Methods: Fifteen patients with submandibular sialolithiasis who underwent CT and salivary gland scintigraphy were included in this study. The relationship between the CT values of submandibular glands with and without sialoliths and salivary gland Excretion measured using salivary gland scintigraphy was statistically analyzed. Dynamic images were recorded on the computer at 1 frame per 20 seconds. The salivary gland Excretion Fraction was defined as A (before stimulation test [counts/frame]) / B(after stimulation test [counts/frame]) using time-activity curves. Results: The CT values in the submandibular glands with and without sialoliths was 9.9±44.9 Hounsfield units (HU) and 34.2±21.8 HU, respectively (P=.233). Regarding the salivary gland Excretion Fraction using scintigraphy, the A/B value in the submandibular glands with sialoliths (1.09±0.23) was significantly lower than in the submandibular glands without sialoliths (1.99±0.57, P=.000). Conclusion: Assessments of the CT values and the salivary gland Excretion Fraction using scintigraphy in the submandibular glands seem to be useful tools evaluating submandibular sialolithiasis.