The Experts below are selected from a list of 1002 Experts worldwide ranked by ideXlab platform

Lars Ericson - One of the best experts on this subject based on the ideXlab platform.

Jeremy J. Burdon - One of the best experts on this subject based on the ideXlab platform.

W J Muller - One of the best experts on this subject based on the ideXlab platform.

  • the rust pathogen triphragmium ulmariae as a selective force affecting its host Filipendula ulmaria
    Journal of Ecology, 2002
    Co-Authors: Lars Ericson, Jeremy J. Burdon, W J Muller
    Abstract:

    Summary 1 The rust fungus Triphragmium ulmariae had a substantial effect on the survival of seedlings of Filipendula ulmaria with 89% dying over a 5-year period. Throughout the experiment, plants that survived the entire study period consistently showed very low disease severity when compared to that suffered by plants that died during its course. 2 The resistance of F. ulmaria to T. ulmariae was assessed through inoculation of progeny of six geographically separated populations of F. ulmariae with four bulk populations of T. ulmariae. Significant differences in resistance as expressed by differences in pathogen prevalence and severity were detected among the F. ulmaria populations. Within individual host populations, significant differences were also detected among open-pollinated family lines. 3 Although in some instances the susceptibility of host populations was greatest towards the pathogen collected from the same site, there was no consistent evidence for local adaptation. 4 An unplanned infection by Septoria ulmariae allowed assessment of resistance within F. ulmaria towards a single population of this pathogen. Again variation for resistance was detected among host populations and among family lines within some of the populations.

  • Temporal and Spatial Changes in a Metapopulation of the Rust Pathogen Triphragmium ulmariae and its Host, Filipendula ulmaria
    The Journal of Ecology, 1995
    Co-Authors: Jeremy J. Burdon, Lars Ericson, W J Muller
    Abstract:

    1 The numerical dynamics of a rust disease caused by the pathogen Triphragmium ulmariae was studied in a metapopulation of 129 discrete populations of the host plant Filipendula ulmaria. 2 Over the four years 1990-1993, 37% of the populations were consistently infected by the pathogen while 43% were always healthy. In the remaining 20% of populations, the presence of disease fluctuated from year-to-year. 3 In each of the four years the incidence of disease was strongly positively correlated with the logarithm of host population size (P < 0.001). Disease incidence was also weakly affected by the type of shore on which host populations grew but not by their degree of exposure. 4 The severity of disease occurring in infected populations was weakly positively correlated with the logarithm of population size (P < 0.05). However, the relationship between the density of individuals within populations and disease prevalence showed no density-dependence. 5 The distribution of disease among populations of the metapopulation had a significant spatial component in two of the years, with infected populations being closer together than would be expected by chance.

Jelena Katanić - One of the best experts on this subject based on the ideXlab platform.

  • Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016
    Co-Authors: Jelena Katanić, Tatjana Boroja, Nevena Stanković, Vladimir Mihailović, Milan Mladenović, Sanja Matić, Eva-maria Pferschy-wenzig, Nadine Kretschmer, Vesna Stanković, Snežana Stanić
    Abstract:

    Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.

  • In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria) as anti-inflammatory agent
    Journal of ethnopharmacology, 2016
    Co-Authors: Jelena Katanić, Tatjana Boroja, Vladimir Mihailović, Stefanie Nikles, San-po Pan, Gvozden Rosic, Dragica Selakovic, Jovana Joksimovic, Slobodanka Mitrovic, Rudolf Bauer
    Abstract:

    Abstract Ethnopharmacological relevance Meadowsweet ( Filipendula ulmaria (L.) Maxim, Rosaceae) has been traditionally used in most European countries for the treatment of inflammatory diseases due to its antipyretic, analgesic, astringent, and anti-rheumatic properties. However, there is little scientific evidence on F. ulmaria anti-inflammatory effects regarding its impact on cyclooxygenases enzymatic activity and in vivo assessment of anti-inflammatory potential. This study aims to reveal the anti-inflammatory activity of methanolic extracts from the aerial parts (FUA) and roots (FUR) of F. ulmaria , both in in vitro and in vivo conditions. Materials and methods The characteristic phenolic compounds in F. ulmaria extracts were monitored via high performance thin layer chromatography (HPTLC). The in vitro anti-inflammatory activity of F. ulmaria extracts was evaluated using cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme assays, and an assay for determining COX-2 gene expression. The in vivo anti-inflammatory effect of F. ulmaria extracts was determined in two doses (100 and 200 mg/kg b.w.) with hot plate test and carrageenan-induced paw edema test in rats. Inflammation was also evaluated by histopathological and immunohistochemical analysis. Results FUA extract showed the presence of rutoside, spiraeoside, and isoquercitrin. Both F. ulmaria extracts at a concentration of 50 μg/mL were able to inhibit COX-1 and -2 enzyme activities, whereby FUA extract (62.84% and 46.43% inhibition, respectively) was double as effective as the root extract (32.11% and 20.20%, respectively). Extracts hardly inhibited the level of COX-2 gene expression in THP-1 cells at a concentration of 25 μg/mL (10.19% inhibition by FUA and 8.54% by FUR). In the hot plate test, both extracts in two doses (100 and 200 mg/kg b.w.), exhibited an increase in latency time when compared with the control group ( p p Conclusions The observed results of in vitro and, for the first time, in vivo anti-inflammatory activity of meadowsweet extracts, provide support of the traditional use of this plant in the treatment of different inflammatory conditions. Further investigation of the anti-inflammatory compounds could reveal the mechanism of anti-inflammatory action of these extracts.

  • In vitro and in vivo assessment of the genotoxicity and antigenotoxicity of the Filipendula hexapetala and Filipendula ulmaria methanol extracts.
    Journal of ethnopharmacology, 2015
    Co-Authors: Sanja Matić, Jelena Katanić, Nevena Stanković, Vladimir Mihailović, Milan Mladenović, Snežana Stanić, Tatjana Boroja
    Abstract:

    Abstract Ethnopharmacological relevance The two species of Filipendula genus, Filipendula hexapetala Gilib. and Filipendula ulmaria (L.) Maxim are a traditional herbal medicine widely used to treat haemorrhoids, diarrhoea, fever, rheumatism and arthritic pain, kidney problems, to stop bleeding, and the common cold, as well as food supplements. However, no scientific study has been performed to validate genotoxic and/or antigenotoxic potentials of these two Filipendula species. Aim of the study The aim of the present study was to examine the genotoxic and possible in vitro and in vivo DNA protection potential of methanol extracts of F. hexapetala and F. ulmaria . Materials and methods The genotoxicity of different concentrations of F. hexapetala and F. ulmaria methanol extracts from roots and aerial parts (20, 40 and 80 mg/ml), mixed with standard food for Drosophila , was evaluated in vivo in the anterior midgut of Drosophila melanogaster using a modified alkaline comet assay. The protective effects of the highest dose of extracts were observed in somatic cells of third-instar larvae against ethyl methanesulphonate (EMS)-induced genotoxicity. Also, DNA protection activity of methanol extracts from F. hexapetala and F. ulmaria (100, 200, and 400 μg/ml) against hydroxyl radical-induced DNA damage was determined under in vitro conditions. Results The results showed that methanol extracts from the root and aerial part of F. hexapetala at a concentration of 20 mg/ml indicated the absence of genotoxicity. Also, there were no statistically significant differences in total scores between any of the groups treated with F. ulmaria root extract and the negative control group, while F. ulmaria aerial part extract possess weak genotoxic effects depending on the concentrations. The percentage reduction in DNA damage was more evident in the group of larvae simultaneously treated with EMS and the highest dose of F. hexapetala root or aerial part extracts and F. ulmaria root extract (91.02, 80.21, and 87.5%, respectively) and less expressive in the group simultaneously treated with F. ulmaria aerial part extract (54.7%). F. hexapetala root and aerial part extracts and F. ulmaria root extract possess strong capabilities to protect DNA from being damaged by hydroxyl radicals. Conclusions It can be concluded that F. hexapetala root and aerial part extracts and F. ulmaria root extract demonstrated the absence of genotoxic activity. The extracts appeared to have antigenotoxic effect, reducing the levels of DNA damage induced by EMS by more than 80%. Also, F. hexapetala root and aerial part extracts and F. ulmaria root extracts could effectively protect against hydroxyl radical-induced DNA damage.

  • Bioactivity, stability and phenolic characterization of Filipendula ulmaria (L.) Maxim.
    Food & function, 2015
    Co-Authors: Jelena Katanić, Tatjana Boroja, Nevena Stanković, Vladimir Mihailović, Milan Mladenović, Samo Kreft, Miroslav M. Vrvić
    Abstract:

    The purpose of the present study was to evaluate the antioxidant and antimicrobial potential of Filipendula ulmaria (L.) Maxim. methanolic extracts, their stabilities under different pH and thermal conditions and in vitro digestibility. The results showed a considerable content of phenolic compounds in the extracts, especially total phenolic acids (47.47 mg CAE g−1) and flavonoids (45.47 mg RUE g−1) in aerial parts. HPLC analysis indicated the presence of spiraeoside in the aerial part extract. The extracts revealed an interesting antimicrobial effect against the tested microorganisms, especially bacteria E. coli and E. faecalis (MIC 0.156–0.625 mg mL−1), and fungi P. cyclopium and F. oxysporum (MIC 2.5–5 mg mL−1). The extracts exerted high antioxidant activities, particularly the root extract, paralleled by their considerable activities against the lipid oxidation process. The results of this study suggest that both extracts potentially could be functional food ingredients considering their good antioxidant and antimicrobial activities, and stability under different conditions.

Tatjana Boroja - One of the best experts on this subject based on the ideXlab platform.

  • Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016
    Co-Authors: Jelena Katanić, Tatjana Boroja, Nevena Stanković, Vladimir Mihailović, Milan Mladenović, Sanja Matić, Eva-maria Pferschy-wenzig, Nadine Kretschmer, Vesna Stanković, Snežana Stanić
    Abstract:

    Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.

  • In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria) as anti-inflammatory agent
    Journal of ethnopharmacology, 2016
    Co-Authors: Jelena Katanić, Tatjana Boroja, Vladimir Mihailović, Stefanie Nikles, San-po Pan, Gvozden Rosic, Dragica Selakovic, Jovana Joksimovic, Slobodanka Mitrovic, Rudolf Bauer
    Abstract:

    Abstract Ethnopharmacological relevance Meadowsweet ( Filipendula ulmaria (L.) Maxim, Rosaceae) has been traditionally used in most European countries for the treatment of inflammatory diseases due to its antipyretic, analgesic, astringent, and anti-rheumatic properties. However, there is little scientific evidence on F. ulmaria anti-inflammatory effects regarding its impact on cyclooxygenases enzymatic activity and in vivo assessment of anti-inflammatory potential. This study aims to reveal the anti-inflammatory activity of methanolic extracts from the aerial parts (FUA) and roots (FUR) of F. ulmaria , both in in vitro and in vivo conditions. Materials and methods The characteristic phenolic compounds in F. ulmaria extracts were monitored via high performance thin layer chromatography (HPTLC). The in vitro anti-inflammatory activity of F. ulmaria extracts was evaluated using cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme assays, and an assay for determining COX-2 gene expression. The in vivo anti-inflammatory effect of F. ulmaria extracts was determined in two doses (100 and 200 mg/kg b.w.) with hot plate test and carrageenan-induced paw edema test in rats. Inflammation was also evaluated by histopathological and immunohistochemical analysis. Results FUA extract showed the presence of rutoside, spiraeoside, and isoquercitrin. Both F. ulmaria extracts at a concentration of 50 μg/mL were able to inhibit COX-1 and -2 enzyme activities, whereby FUA extract (62.84% and 46.43% inhibition, respectively) was double as effective as the root extract (32.11% and 20.20%, respectively). Extracts hardly inhibited the level of COX-2 gene expression in THP-1 cells at a concentration of 25 μg/mL (10.19% inhibition by FUA and 8.54% by FUR). In the hot plate test, both extracts in two doses (100 and 200 mg/kg b.w.), exhibited an increase in latency time when compared with the control group ( p p Conclusions The observed results of in vitro and, for the first time, in vivo anti-inflammatory activity of meadowsweet extracts, provide support of the traditional use of this plant in the treatment of different inflammatory conditions. Further investigation of the anti-inflammatory compounds could reveal the mechanism of anti-inflammatory action of these extracts.

  • In vitro and in vivo assessment of the genotoxicity and antigenotoxicity of the Filipendula hexapetala and Filipendula ulmaria methanol extracts.
    Journal of ethnopharmacology, 2015
    Co-Authors: Sanja Matić, Jelena Katanić, Nevena Stanković, Vladimir Mihailović, Milan Mladenović, Snežana Stanić, Tatjana Boroja
    Abstract:

    Abstract Ethnopharmacological relevance The two species of Filipendula genus, Filipendula hexapetala Gilib. and Filipendula ulmaria (L.) Maxim are a traditional herbal medicine widely used to treat haemorrhoids, diarrhoea, fever, rheumatism and arthritic pain, kidney problems, to stop bleeding, and the common cold, as well as food supplements. However, no scientific study has been performed to validate genotoxic and/or antigenotoxic potentials of these two Filipendula species. Aim of the study The aim of the present study was to examine the genotoxic and possible in vitro and in vivo DNA protection potential of methanol extracts of F. hexapetala and F. ulmaria . Materials and methods The genotoxicity of different concentrations of F. hexapetala and F. ulmaria methanol extracts from roots and aerial parts (20, 40 and 80 mg/ml), mixed with standard food for Drosophila , was evaluated in vivo in the anterior midgut of Drosophila melanogaster using a modified alkaline comet assay. The protective effects of the highest dose of extracts were observed in somatic cells of third-instar larvae against ethyl methanesulphonate (EMS)-induced genotoxicity. Also, DNA protection activity of methanol extracts from F. hexapetala and F. ulmaria (100, 200, and 400 μg/ml) against hydroxyl radical-induced DNA damage was determined under in vitro conditions. Results The results showed that methanol extracts from the root and aerial part of F. hexapetala at a concentration of 20 mg/ml indicated the absence of genotoxicity. Also, there were no statistically significant differences in total scores between any of the groups treated with F. ulmaria root extract and the negative control group, while F. ulmaria aerial part extract possess weak genotoxic effects depending on the concentrations. The percentage reduction in DNA damage was more evident in the group of larvae simultaneously treated with EMS and the highest dose of F. hexapetala root or aerial part extracts and F. ulmaria root extract (91.02, 80.21, and 87.5%, respectively) and less expressive in the group simultaneously treated with F. ulmaria aerial part extract (54.7%). F. hexapetala root and aerial part extracts and F. ulmaria root extract possess strong capabilities to protect DNA from being damaged by hydroxyl radicals. Conclusions It can be concluded that F. hexapetala root and aerial part extracts and F. ulmaria root extract demonstrated the absence of genotoxic activity. The extracts appeared to have antigenotoxic effect, reducing the levels of DNA damage induced by EMS by more than 80%. Also, F. hexapetala root and aerial part extracts and F. ulmaria root extracts could effectively protect against hydroxyl radical-induced DNA damage.

  • Bioactivity, stability and phenolic characterization of Filipendula ulmaria (L.) Maxim.
    Food & function, 2015
    Co-Authors: Jelena Katanić, Tatjana Boroja, Nevena Stanković, Vladimir Mihailović, Milan Mladenović, Samo Kreft, Miroslav M. Vrvić
    Abstract:

    The purpose of the present study was to evaluate the antioxidant and antimicrobial potential of Filipendula ulmaria (L.) Maxim. methanolic extracts, their stabilities under different pH and thermal conditions and in vitro digestibility. The results showed a considerable content of phenolic compounds in the extracts, especially total phenolic acids (47.47 mg CAE g−1) and flavonoids (45.47 mg RUE g−1) in aerial parts. HPLC analysis indicated the presence of spiraeoside in the aerial part extract. The extracts revealed an interesting antimicrobial effect against the tested microorganisms, especially bacteria E. coli and E. faecalis (MIC 0.156–0.625 mg mL−1), and fungi P. cyclopium and F. oxysporum (MIC 2.5–5 mg mL−1). The extracts exerted high antioxidant activities, particularly the root extract, paralleled by their considerable activities against the lipid oxidation process. The results of this study suggest that both extracts potentially could be functional food ingredients considering their good antioxidant and antimicrobial activities, and stability under different conditions.