The Experts below are selected from a list of 13335 Experts worldwide ranked by ideXlab platform
Charles M. Lieber - One of the best experts on this subject based on the ideXlab platform.
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mesh Nanoelectronics seamless integration of electronics with tissues
Accounts of Chemical Research, 2018Co-Authors: Xiaochuan Dai, Guosong Hong, Teng Gao, Charles M. LieberAbstract:ConspectusNanobioelectronics represents a rapidly developing field with broad-ranging opportunities in fundamental biological sciences, biotechnology, and medicine. Despite this potential, seamless integration of electronics has been difficult due to fundamental mismatches, including size and mechanical properties, between the elements of the electronic and living biological systems.In this Account, we discuss the concept, development, key demonstrations, and future opportunities of mesh Nanoelectronics as a general paradigm for seamless integration of electronics within synthetic tissues and live animals. We first describe the design and realization of hybrid synthetic tissues that are innervated in three dimensions (3D) with mesh Nanoelectronics where the mesh serves as both as a tissue scaffold and as a platform of addressable electronic devices for monitoring and manipulating tissue behavior. Specific examples of tissue/nanoelectronic mesh hybrids highlighted include 3D neural tissue, cardiac patches,...
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Nanoelectronics circuits and nanoprocessors
2016Co-Authors: Anqi Zhang, Gengfeng Zheng, Charles M. LieberAbstract:As electronic device features have been pushed into the deep sub-100-nm regime, conventional scaling strategies in the semiconductor industry have faced technological and economic challenges. Electronics obtained through the bottom-up approach of molecular-level control of material composition and structure may lead to devices and fabrication strategies as well as new architectures not readily accessible or even possible within the context of the top-down driven industry and manufacturing infrastructure. This chapter presents a summary of recent advances in basic Nanoelectronics devices, simple circuits and nanoprocessors assembled by semiconductor NWs.
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Multifunctional three-dimensional macroporous nanoelectronic networks for smart materials
Proceedings of the National Academy of Sciences, 2013Co-Authors: Jun Liu, C. Xie, Lihua Jin, X Dai, W Zhou, Jia Liu, Charles M. LieberAbstract:Seamless and minimally invasive integration of 3D electronic circuitry within host materials could enable the development of materials systems that are self-monitoring and allow for communication with external environments. Here, we report a general strategy for preparing ordered 3D interconnected and addressable macroporous nanoelectronic networks from ordered 2D nanowire nanoelectronic precursors, which are fabricated by conventional lithography. The 3D networks have porosities larger than 99%, contain approximately hundreds of addressable nanowire devices, and have feature sizes from the 10-μm scale (for electrical and structural interconnections) to the 10-nm scale (for device elements). The macroporous nanoelectronic networks were merged with organic gels and polymers to form hybrid materials in which the basic physical and chemical properties of the host were not substantially altered, and electrical measurements further showed a >90% yield of active devices in the hybrid materials. The positions of the nanowire devices were located within 3D hybrid materials with ∼14-nm resolution through simultaneous nanowire device photocurrent/confocal microscopy imaging measurements. In addition, we explored functional properties of these hybrid materials, including (i) mapping time-dependent pH changes throughout a nanowire network/agarose gel sample during external solution pH changes, and (ii) characterizing the strain field in a hybrid nanoelectronic elastomer structures subject to uniaxial and bending forces. The seamless incorporation of active nanoelectronic networks within 3D materials reveals a powerful approach to smart materials in which the capabilities of multifunctional Nanoelectronics allow for active monitoring and control of host systems.
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Nanoelectronics meets biology
Bulletin of the American Physical Society, 2012Co-Authors: Charles M. LieberAbstract:Nanoscale materials enable unique opportunities at the interface between the physical and life sciences, and the interface between nanoelectronic devices and biological systems makes possible communication between these two diverse systems at the length scale relevant to biological function. In this presentation, the development of nanowire nanoelectronic devices and their application as powerful tools for the life sciences will be discussed. First, a brief introduction to nanowire nanoelectronic devices as well as comparisons to other electrophysiological tools will be presented to illuminate the unique strengths and opportunities enabled at the nanoscale. Second, illustration of detection capabilities including signal-to-noise and applications for real-time label-free detection of biochemical markers down to the level of single molecules will be described. Third, the use of nanowire Nanoelectronics for building interfaces to cells and tissues will be reviewed. Multiplexed measurements made from nanowire devices fabricated on flexible and transparent substrates recording signal propagation across cultured cells, acute tissue slices and intact organs will be illustrated, including quantitative analysis of the high simultaneous spatial and temporal resolution achieved with these nanodevices. Specific examples of subcellular and near point detection of extracellular potential will be used to illustrate the unique capabilities, such as recording localized potential changes due to neuronal activities simultaneously across many length scales, which provide key information for functional neural circuit studies. Last, emerging opportunities for the creation of powerful new probes based on controlled synthesis and/or bottom-up assembly of nanomaterials will be described with an emphasis on the creation of kinked nanowire probes capable of first intracellular transistor recordings. The prospects for blurring the distinction between nanoelectronic and living systems in the future will be highlighted.
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semiconductor nanowires a platform for nanoscience and nanotechnology
Mrs Bulletin, 2011Co-Authors: Charles M. LieberAbstract:Advances in nanoscience and nanotechnology critically depend on the development of nanostructures whose properties are controlled during synthesis. We focus on this critical concept using semiconductor nanowires, which provide the capability through design and rational synthesis to realize unprecedented structural and functional complexity in building blocks as a platform material. First, a brief review of the synthesis of complex modulated nanowires in which rational design and synthesis can be used to precisely control composition, structure, and, most recently, structural topology is discussed. Second, the unique functional characteristics emerging from our exquisite control of nanowire materials are illustrated using several selected examples from Nanoelectronics and nano-enabled energy. Finally, the remarkable power of nanowire building blocks is further highlighted through their capability to create unprecedented, active electronic interfaces with biological systems. Recent work pushing the limits of both multiplexed extracellular recording at the single-cell level and the first examples of intracellular recording is described, as well as the prospects for truly blurring the distinction between nonliving nanoelectronic and living biological systems.
Ramesh Karri - One of the best experts on this subject based on the ideXlab platform.
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interactive presentation logic level fault tolerance approaches targeting Nanoelectronics plas
Design Automation and Test in Europe, 2007Co-Authors: Alex Orailoglu, Ramesh KarriAbstract:A regular structure and capability to implement arbitrary logic functions in a two-level logic form have placed crossbar-based Programmable Logic Arrays (PLAs) as promising implementation architectures in the emerging Nanoelectronics environment. Yet reliability constitutes an important concern in the Nanoelectronics environment, necessitating a thorough investigation and its effective augmentation for crossbar-based PLAs. We investigate in this paper fault masking for crossbar-based Nanoelectronics PLAs. Missing Nanoelectronics devices at the crosspoints have been observed as a major source of faults in Nanoelectronics crossbars. Based on this observation, we present a class of fault masking approaches exploiting logic tautology in two-level PLAs. The proposed approaches enhance the reliability of Nanoelectronics PLAs significantly at low hardware cost.
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Logic Level Fault Tolerance Approaches Targeting Nanoelectronics PLAs
2007 Design Automation & Test in Europe Conference & Exhibition, 2007Co-Authors: Wenjing Rao, Alex Orailoglu, Ramesh KarriAbstract:A regular structure and capability to implement arbitrary logic functions in a two-level logic form have placed crossbar-based programmable logic arrays (PLAs) as promising implementation architectures in the emerging Nanoelectronics environment. Yet reliability constitutes an important concern in the Nanoelectronics environment, necessitating a thorough investigation and its effective augmentation for crossbar-based PLAs. We investigate in this paper fault masking for crossbar-based Nanoelectronics PLAs. Missing Nanoelectronics devices at the crosspoints have been observed as a major source of faults in Nanoelectronics crossbars. Based on this observation, we present a class of fault masking approaches exploiting logic tautology in two-level PLAs. The proposed approaches enhance the reliability of Nanoelectronics PLAs significantly at low hardware cost
Xiaojie Dua - One of the best experts on this subject based on the ideXlab platform.
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Nanoelectronics biology frontier from nanoscopic probes for action potential recording in live cells to three dimensional cyborg tissues
Nano Today, 2013Co-Authors: Jia Liu, Xiaojie Dua, Charles M LiebeAbstract:Semiconductor nanowires configured as the active channels of field-effect transistors (FETs) have been used as detectors for high-resolution electrical recording from single live cells, cell networks, tissues and organs. Extracellular measurements with substrate supported silicon nanowire (SiNW) FETs, which have projected active areas orders of magnitude smaller than conventional microfabricated multielectrode arrays (MEAs) and planar FETs, recorded action potential and field potential signals with high signal-to-noise ratio and temporal resolution from cultured neurons, cultured cardiomyocytes, acute brain slices and whole animal hearts. Measurements made with modulation-doped nanoscale active channel SiNW FETs demonstrate that signals recorded from cardiomyocytes are highly localized and have improved time resolution compared to larger planar detectors. In addition, several novel three-dimensional (3D) transistor probes, which were realized using advanced nanowire synthesis methods, have been implemented for intracellular recording. These novel probes include (i) flexible 3D kinked nanowire FETs, (ii) branched intracellular nanotube SiNW FETs, and (iii) active silicon nanotube FETs. Following phospholipid modification of the probes to mimic the cell membrane, the kinked nanowire, branched intracellular nanotube and active silicon nanotube FET probes recorded full-amplitude intracellular action potentials from spontaneously firing cardiomyocytes. Moreover, these probes demonstrated the capability of reversible, stable, and long-term intracellular recording, thus indicating the minimal invasiveness of the new nanoscale structures and suggesting biomimetic internalization via the phospholipid modification. Simultaneous, multi-site intracellular recording from both single cells and cell networks were also readily achieved by interfacing independently addressable nanoprobe devices with cells. Finally, electronic and biological systems have been seamlessly merged in 3D for the first time using macroporous nanoelectronic scaffolds that are analogous to synthetic tissue scaffold and the extracellular matrix in tissue. Free-standing 3D nanoelectronic scaffolds were cultured with neurons, cardiomyocytes and smooth muscle cells to yield electronically-innervated synthetic or ‘cyborg’ tissues. Measurements demonstrate that innervated tissues exhibit similar cell viability as with conventional tissue scaffolds, and importantly, demonstrate that the real-time response to drugs and pH changes can be mapped in 3D through the tissues. These results open up a new field of research, wherein Nanoelectronics are merged with biological systems in 3D thereby providing broad opportunities, ranging from a nanoelectronic/tissue platform for real-time pharmacological screening in 3D to implantable ‘cyborg’ tissues enabling closed-loop monitoring and treatment of diseases. Furthermore, the capability of high density scale-up of the above extra- and intracellular nanoscopic probes for action potential recording provide important tools for large-scale high spatio-temporal resolution electrical neural activity mapping in both 2D and 3D, which promises to have a profound impact on many research areas, including the mapping of activity within the brain.
Thomas S Blum - One of the best experts on this subject based on the ideXlab platform.
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cyborg organoids implantation of Nanoelectronics via organogenesis for tissue wide electrophysiology
Nano Letters, 2019Co-Authors: Qiang Li, Paul Le Floch, Hao Sheng, Thomas S BlumAbstract:Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies. Issues arise, however, from the invasive, localized implantation of electronics that destroys well-connected cellular networks within matured organs. Here, we report the creation of cyborg organoids: the three-dimensional (3D) assembly of soft, stretchable mesh Nanoelectronics across the entire organoid by the cell–cell attraction forces from 2D-to-3D tissue reconfiguration during organogenesis. We demonstrate that stretchable mesh Nanoelectronics can migrate with and grow into the initial 2D cell layers to form the 3D organoid structure with minimal impact on tissue growth and differentiation. The intimate contact between the dispersed Nanoelectronics and cells enables us to chronically and systematically observe the evolution, propagation, and synchronization of the bursting dynamics in human cardiac organoids through their entire organogenesis.
Xiaolin Zheng - One of the best experts on this subject based on the ideXlab platform.
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wafer recyclable environment friendly transfer printing for large scale thin film Nanoelectronics
Proceedings of the National Academy of Sciences of the United States of America, 2018Co-Authors: Dae Seung Wie, Xiaolin Zheng, Yue Zhang, Min Ku Kim, Bongjoong Kim, Sangwook Park, Youngjoon Kim, Pedro P Irazoqui, Chi Hwan LeeAbstract:Transfer printing of thin-film Nanoelectronics from their fabrication wafer commonly requires chemical etching on the sacrifice of wafer but is also limited by defects with a low yield. Here, we introduce a wafer-recyclable, environment-friendly transfer printing process that enables the wafer-scale separation of high-performance thin-film Nanoelectronics from their fabrication wafer in a defect-free manner that enables multiple reuses of the wafer. The interfacial delamination is enabled through a controllable cracking phenomenon in a water environment at room temperature. The physically liberated thin-film Nanoelectronics can be then pasted onto arbitrary places of interest, thereby endowing the particular surface with desirable add-on electronic features. Systematic experimental, theoretical, and computational studies reveal the underlying mechanics mechanism and guide manufacturability for the transfer printing process in terms of scalability, controllability, and reproducibility.
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Coaxial silicon nanowires as solar cells and nanoelectronic power sources.
Nature, 2007Co-Authors: Bozhi Tian, Thomas J. Kempa, Jinlin Huang, Guihua Yu, Ying Fang, Nanfang Yu, Xiaolin Zheng, Charles M. LieberAbstract:Solar cells are attractive candidates for clean and renewable power; with miniaturization, they might also serve as integrated power sources for nanoelectronic systems. The use of nanostructures or nanostructured materials represents a general approach to reduce both cost and size and to improve efficiency in photovoltaics. Nanoparticles, nanorods and nanowires have been used to improve charge collection efficiency in polymer-blend and dye-sensitized solar cells, to demonstrate carrier multiplication, and to enable low-temperature processing of photovoltaic devices. Moreover, recent theoretical studies have indicated that coaxial nanowire structures could improve carrier collection and overall efficiency with respect to single-crystal bulk semiconductors of the same materials. However, solar cells based on hybrid nanoarchitectures suffer from relatively low efficiencies and poor stabilities. In addition, previous studies have not yet addressed their use as photovoltaic power elements in Nanoelectronics. Here we report the realization of p-type/intrinsic/n-type (p-i-n) coaxial silicon nanowire solar cells. Under one solar equivalent (1-sun) illumination, the p-i-n silicon nanowire elements yield a maximum power output of up to 200 pW per nanowire device and an apparent energy conversion efficiency of up to 3.4 per cent, with stable and improved efficiencies achievable at high-flux illuminations. Furthermore, we show that individual and interconnected silicon nanowire photovoltaic elements can serve as robust power sources to drive functional nanoelectronic sensors and logic gates. These coaxial silicon nanowire photovoltaic elements provide a new nanoscale test bed for studies of photoinduced energy/charge transport and artificial photosynthesis, and might find general usage as elements for powering ultralow-power electronics and diverse nanosystems.
