The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Raymond L Barnhill - One of the best experts on this subject based on the ideXlab platform.
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superficial melanocytic neoplasms with Pagetoid melanocytosis a study of interobserver concordance and correlation with fish
The American Journal of Surgical Pathology, 2010Co-Authors: Pedram Gerami, Raymond L Barnhill, Beth Beilfuss, Philip E Leboit, P Schneider, Joan GuitartAbstract:Pagetoid proliferation of single melanocytic cells or small nests of melanocytes may be seen in a variety of melanocytic neoplasms including Pagetoid spitz nevi, de novo epithelioid melanocytic dysplasia, and melanoma. Distinction of these entities may be difficult as there is considerable clinical
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Pagetoid spitz nevus intraepidermal spitz tumor with prominent Pagetoid spread
The American Journal of Surgical Pathology, 1995Co-Authors: Klaus J Busam, Raymond L BarnhillAbstract:A distinctive variant of melanocytic growth pattern is described, which appears to be related to Spitz nevus and is characterized by a mainly intraepidermal proliferation of large epithelioid melanocytes with a predominantly Pagetoid distribution. This melanocytic lesion appears clinically as a small (<0.4 cm) pigmented macule in young patients. Histologically, this lesion needs to be distinguished primarily from in situ or microinvasive malignant melanoma with Pagetoid spread. Features favoring nevus over melanoma include small size, circumscription, symmetry, even distribution of cells, and lack of marked cytologic atypia.
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Pagetoid Spitz nevus: intraepidermal Spitz tumor with prominent Pagetoid spread
The American Journal of Surgical Pathology, 1995Co-Authors: Klaus J Busam, Raymond L BarnhillAbstract:A distinctive variant of melanocytic growth pattern is described, which appears to be related to Spitz nevus and is characterized by a mainly intraepidermal proliferation of large epithelioid melanocytes with a predominantly Pagetoid distribution. This melanocytic lesion appears clinically as a small (
P Martin - One of the best experts on this subject based on the ideXlab platform.
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mitomycin c in sebaceous gland carcinoma with Pagetoid spread
British Journal of Ophthalmology, 2004Co-Authors: K Tumuluri, G Kourt, P MartinAbstract:Sebaceous gland carcinoma is a rare eyelid tumour comprising less than 1% of all eyelid malignancies.1 It commonly arises from the meibomian glands of the tarsus, but may also arise from the glands of Zeis or from the sebaceous glands of caruncle.2 It can present in a nodular or diffuse infiltrative form. The latter form with intraepithelial (Pagetoid) invasion has poor prognosis as a result of delay in diagnosis as well as more extensive involvement of ocular tissues. Topical application of mitomycin C, a non-cell cycle specific alkylating agent, has been advocated for Pagetoid spread of sebaceous gland carcinoma.3 We report the use of mitomycin C as adjuvant therapy in a patient with completely excised sebaceous gland carcinoma and Pagetoid …
J M Theaker - One of the best experts on this subject based on the ideXlab platform.
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Pagetoid spread into the rete testis by testicular tumours
Histopathology, 1994Co-Authors: J M TheakerAbstract:Germ cell neoplasia of the testis can spread into the rete testis in a Pagetoid manner, but this is less often recognized than vascular invasion or direct spread into the tunica albuginea. The rete testis was studied in 71 orchidectomy specimens: 47 with an untreated germ cell tumour, 18 with germ cell neoplasia after treatment with chemotherapy, and six with other tumours. Pagetoid spread into the rete testis was seen in 14 of the 47 cases of germ cell tumour. The cytology of the infiltrating cells was that of intratubular germ cell neoplasia. Hyperplasia of the rete testis was seen in six cases. In three of the four testes with untreated germ cell neoplasia and hyperplasia of the rete, neoplastic cells were seen in the hyperplastic rete epithelium. The two testes with extensive Pagetoid involvement of the rete testis by intratubular germ cell neoplasia both had associated hyperplasia of the rete testis. Two of the 18 testes with germ cell neoplasia after chemotherapy had focal hyperplasia. Pagetoid involvement of the rete testis by intratubular germ cell neoplasia is common and may be a cause of hyperplasia of the rete testis.
Jorge Alboressaavedra - One of the best experts on this subject based on the ideXlab platform.
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Pagetoid spread of intratubular germ cell neoplasia into rete testis a morphologic and histochemical study of 100 orchiectomy specimens with invasive germ cell tumors
Human Pathology, 1994Co-Authors: Arie Perry, Elizabeth L Wiley, Jorge AlboressaavedraAbstract:Abstract Intratubular germ cell neoplasia (ITGCN) is now considered to be the preinvasive phase of testicular germ cell tumors with the exceptions of spermatocytic seminoma, pure yolk sac tumor, and mature teratoma. Pagetoid spread of ITGCN into rete testis is a common yet unpublished finding in these cases. We reviewed 100 cases of testicular germ cell tumors from the Surgical Pathology service of Parkland Memorial Hospital (Dallas, TX) to evaluate the frequency of this pattern of spread. Additional sections were obtained from selected cases and were stained with anti-placental alkaline phosphatase, anti-low molecular weight keratin (clone AE1), and various lectins to highlight the process. Pagetoid spread of ITGCN into rete testis was identified in 24 of 60 cases (40%) in which histologic sections contained both ITGCN and rete testis. The incidence of Pagetoid ITGCN involvement of the rete testis was lower in pure seminoma (seven of 25 cases [28%]) than in testes containing nonseminomatous germ cell tumors (17 of 35 cases [49%]). AE1 stained the epithelial cells of the rete testis but not the cells of the ITGCN, whereas placental alkaline phosphatase stained the neoplastic cells but not the epithelial cells of the rete testis. These stains were useful in delineating two cases in which the Pagetoid involvement was so extensive that they were misdiagnosed as invasive seminomas. Pagetoid spread of ITGCN is a relatively common finding in testicular germ cell tumors and rarely can be mistaken for invasive seminoma. Immunohistochemistry can be helpful in distinguishing florid Pagetoid spread from invasive seminoma.
Sabine Kohler - One of the best experts on this subject based on the ideXlab platform.
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keratin profile of intraepidermal cells in paget s disease extramammary paget s disease and Pagetoid squamous cell carcinoma in situ
Journal of Cutaneous Pathology, 2003Co-Authors: Sabine KohlerAbstract:Background: Although the histopathologic differential diagnosis of Pagetoid neoplasms is broad, unique histopathologic identifiers and clinical correlation can often identify the process. However, in the case of mammary Paget's disease (MPD) or extramammary Paget's disease (EPD) without an obvious underlying malignancy, distinction from Pagetoid squamous cell carcinoma in situ (PSCCIS) can be challenging. Our goal was to better define the immunohistochemical staining patterns of these three entities in the hope of determining distinctive staining patterns. Methods: We evaluated nine cases of PSCCIS, five cases of MPD, and 10 cases of EPD with the immunohistochemical antibodies CAM 5.2 and CK 5/6. In addition, only PSCCIS was stained with CK 7, as the staining patterns of CK 7 in MPD and EPD are well known from prior studies. Results: CAM 5.2 diffusely stained all cases of MPD and EPD and failed to stain any case of PSCCIS. Furthermore, CK 7 only focally stained two of the 10 cases of PSCCIS. CK 5/6 was difficult to interpret due to the high functional background staining of the normal keratinocytes in the epidermis. Conclusions: Based on these results, our data supports the use of CAM 5.2 and CK 7 immunoperoxidase markers in differentiating between difficult cases of PSCCIS and MPD or EPD. An antibody panel consisting of S-100, CAM 5.2, and CK 7 will aid in the accurate diagnosis of almost all Pagetoid neoplasms of the breast or genital skin.
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Pagetoid reticulosis woringer kolopp disease an immunophenotypic molecular and clinicopathologic study
Modern Pathology, 2000Co-Authors: Bijan Haghighi, Bruce R. Smoller, Philip E Leboit, Roger A Warnke, Christian A Sander, Sabine KohlerAbstract:Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
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The differential diagnosis of Pagetoid cells in the epidermis.
Modern Pathology, 1998Co-Authors: Sabine Kohler, Robert V. Rouse, Bruce R. SmollerAbstract:In addition to Paget's disease, a heterogeneous group of processes with diverse histogeneses can give rise to intraepidermal Pagetoid cells. These diseases share as their common denominator the presence of discrete non-Malpighian or abnormal Malpighian cells occurring singly or in nests within the epidermis. Either Pagetoid cells can represent the only histologic change, as in Pagetoid squamous cell carcinoma in situ or superficial spreading malignant melanoma in situ, or they can be an expression of an associated dermal or internal malignancy, as in sebaceous carcinoma or breast carcinoma. The histologic appearance of the Pagetoid cells in these diverse disorders can be quite similar, rendering the differential diagnosis difficult. A review of the entities that enter into the differential diagnosis of intraepidermal Pagetoid cells is presented, emphasizing their distinguishing histologic and immunophenotypic features and differential diagnosis.
